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Plxnc1 plexin C1 [ Mus musculus (house mouse) ]

Gene ID: 54712, updated on 2-Nov-2024

Summary

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Official Symbol
Plxnc1provided by MGI
Official Full Name
plexin C1provided by MGI
Primary source
MGI:MGI:1890127
See related
Ensembl:ENSMUSG00000074785 AllianceGenome:MGI:1890127
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CD232; Vespr; 2510048K12Rik
Summary
Predicted to enable semaphorin receptor activity. Involved in regulation of synapse pruning. Is active in cerebellar climbing fiber to Purkinje cell synapse. Is expressed in several structures, including genitourinary system; heart; nervous system; respiratory system; and sensory organ. Orthologous to human PLXNC1 (plexin C1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in CNS E18 (RPKM 9.0), ovary adult (RPKM 7.4) and 17 other tissues See more
Orthologs
human all
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Genomic context

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See Plxnc1 in Genome Data Viewer
Location:
10 C2; 10 49.09 cM
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (94626728..94780875, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (94790866..94945015, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5171 Neighboring gene STARR-positive B cell enhancer ABC_E6909 Neighboring gene centrosomal protein 83, opposite strand Neighboring gene centrosomal protein 83 Neighboring gene STARR-positive B cell enhancer ABC_E9132 Neighboring gene STARR-seq mESC enhancer starr_27606 Neighboring gene STARR-positive B cell enhancer ABC_E10638 Neighboring gene STARR-seq mESC enhancer starr_27608 Neighboring gene STARR-positive B cell enhancer ABC_E2960 Neighboring gene predicted gene, 53599 Neighboring gene STARR-positive B cell enhancer ABC_E9348 Neighboring gene predicted gene, 40744 Neighboring gene STARR-seq mESC enhancer starr_27609 Neighboring gene STARR-seq mESC enhancer starr_27611 Neighboring gene predicted gene, 53600 Neighboring gene predicted gene, 29684

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Dendritic cell function in mice lacking Plexin C1. Walzer T, et al. Int Immunol, 2005 Jul. PMID 15967782
  2. Plexin C1 engagement on mouse dendritic cells by viral semaphorin A39R induces actin cytoskeleton rearrangement and inhibits integrin-mediated adhesion and chemokine-induced migration. Walzer T, et al. J Immunol, 2005 Jan 1. PMID 15611227
  3. The plexin C1 receptor promotes acute inflammation. König K, et al. Eur J Immunol, 2014 Sep. PMID 24890788
  4. Plexin C1 influences immune response to intracellular LPS and survival in murine sepsis. Bernard A, et al. J Biomed Sci, 2024 Aug 21. PMID 39169397, Free PMC Article
  5. The neural guidance receptor Plexin C1 delays melanoma progression. Chen Y, et al. Oncogene, 2013 Oct 10. PMID 23160370, Free PMC Article

See all (60) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Plexin C1 influences immune response to intracellular LPS and survival in murine sepsis.
    Title: Plexin C1 influences immune response to intracellular LPS and survival in murine sepsis.
  2. The olfactory critical period is determined by activity-dependent Sema7A/PlxnC1 signaling within glomeruli.
    Title: The olfactory critical period is determined by activity-dependent Sema7A/PlxnC1 signaling within glomeruli.
  3. Sema7A-PlxnC1 interaction is essential to form the post-synaptic assembly.
    Title: Sema7A/PlxnCl signaling triggers activity-dependent olfactory synapse formation.
  4. Plxnc1 interaction with Sema7a mediates repulsion of ventral tegmental area neurons.Lmx1a and Lmx1b regulate Plxnc1 expression.
    Title: Transcriptional repression of Plxnc1 by Lmx1a and Lmx1b directs topographic dopaminergic circuit formation.
  5. Plexin C1 deficiency permits synaptotagmin 7-mediated macrophage migration and enhances mammalian lung fibrosis
    Title: Plexin C1 deficiency permits synaptotagmin 7-mediated macrophage migration and enhances mammalian lung fibrosis.
  6. These results implicate an important role of PLXNC1 during an acute inflammatory response and indicate PLXNC1 as a potential target for the control of conditions associated with acute inflammation.
    Title: The plexin C1 receptor promotes acute inflammation.
  7. loss of Plexin C1 in melanoma may promote early steps in melanoma progression through suppression of migration and proliferation
    Title: The neural guidance receptor Plexin C1 delays melanoma progression.
  8. Plexin-C1 displayed R-Ras GAP activity and inhibited cell migration
    Title: Different requirement for Rnd GTPases of R-Ras GAP activity of Plexin-C1 and Plexin-D1.
  9. PlexinC1 gene expression regulation is expressed within the hypohalamic nucleus and supraoptic hypothalamus.
    Title: Allocation of paraventricular and supraoptic neurons requires Sim1 function: a role for a Sim1 downstream gene PlexinC1.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables semaphorin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables semaphorin receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell shape IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of synapse pruning IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of synapse pruning IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in semaphorin-plexin signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in semaphorin-plexin signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in synapse assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cerebellar climbing fiber to Purkinje cell synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cerebellar climbing fiber to Purkinje cell synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of semaphorin receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
plexin-C1
Names
viral-encoded semaphorin protein receptor
virus-encoded semaphorin protein receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018797.3 → NP_061267.1  plexin-C1 precursor

    See identical proteins and their annotated locations for NP_061267.1

    Status: VALIDATED

    Source sequence(s)
    AC159379, AC159542
    Consensus CDS
    CCDS48676.1
    UniProtKB/Swiss-Prot
    Q8CGW1, Q9QZC2
    Related
    ENSMUSP00000096939.3, ENSMUST00000099337.5
    Conserved Domains (5) summary
    cd11246
    Location:44 → 453
    Sema_plexin_C1; The Sema domain, a protein interacting module, of Plexin C1
    smart00429
    Location:755 → 847
    IPT; ig-like, plexins, transcription factors
    pfam01437
    Location:454 → 507
    PSI; Plexin repeat
    pfam01833
    Location:666 → 752
    TIG; IPT/TIG domain
    pfam08337
    Location:1018 → 1541
    Plexin_cytopl; Plexin cytoplasmic RasGAP domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    94626728..94780875 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245180.2 → XP_030101040.1  plexin-C1 isoform X1

    Conserved Domains (5) summary
    cd11246
    Location:185 → 594
    Sema_plexin_C1; The Sema domain, a protein interacting module, of Plexin C1
    smart00429
    Location:896 → 988
    IPT; ig-like, plexins, transcription factors
    pfam01437
    Location:595 → 648
    PSI; Plexin repeat
    pfam01833
    Location:807 → 893
    TIG; IPT/TIG domain
    pfam08337
    Location:1159 → 1681
    Plexin_cytopl; Plexin cytoplasmic RasGAP domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QZC2.1 GenPept UniProtKB/Swiss-Prot:Q9QZC2

Gene LinkOut

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