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Tyk2 tyrosine kinase 2 [ Mus musculus (house mouse) ]

Gene ID: 54721, updated on 2-Nov-2024

Summary

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Official Symbol
Tyk2provided by MGI
Official Full Name
tyrosine kinase 2provided by MGI
Primary source
MGI:MGI:1929470
See related
Ensembl:ENSMUSG00000032175 AllianceGenome:MGI:1929470
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
JTK1
Summary
Predicted to enable growth hormone receptor binding activity; non-membrane spanning protein tyrosine kinase activity; and type 1 angiotensin receptor binding activity. Involved in cell population proliferation and positive regulation of T cell proliferation. Predicted to be located in cytoplasm and nucleus. Predicted to be active in cytosol. Used to study obesity. Human ortholog(s) of this gene implicated in immunodeficiency 35. Orthologous to human TYK2 (tyrosine kinase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in spleen adult (RPKM 21.7), mammary gland adult (RPKM 15.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Tyk2 in Genome Data Viewer
Location:
9 A3; 9 7.71 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (21015364..21042689, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (21104068..21131393, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38431 Neighboring gene ferredoxin 2 Neighboring gene microRNA 7082 Neighboring gene ribonucleoprotein, PTB-binding 1 Neighboring gene STARR-positive B cell enhancer ABC_E459 Neighboring gene STARR-positive B cell enhancer ABC_E1780 Neighboring gene STARR-positive B cell enhancer ABC_E2282 Neighboring gene STARR-positive B cell enhancer ABC_E5054 Neighboring gene cell division cycle 37 Neighboring gene predicted gene, 36118 Neighboring gene predicted gene, 35977 Neighboring gene predicted gene, 39301

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TYK2 kinase activity is required for functional type I interferon responses in vivo. Prchal-Murphy M, et al. PLoS One, 2012. PMID 22723949, Free PMC Article
  2. Kinase Inactive Tyrosine Kinase (Tyk2) Supports Differentiation of Brown Fat Cells. Raje V, et al. Endocrinology, 2017 Jan 1. PMID 27802075, Free PMC Article
  3. Reduced Tyk2 gene expression in β-cells due to natural mutation determines susceptibility to virus-induced diabetes. Izumi K, et al. Nat Commun, 2015 Apr 7. PMID 25849081, Free PMC Article
  4. Role of Tyk-2 in Th9 and Th17 cells in allergic asthma. Übel C, et al. Sci Rep, 2014 Aug 11. PMID 25109392, Free PMC Article
  5. A natural mutation in the Tyk2 pseudokinase domain underlies altered susceptibility of B10.Q/J mice to infection and autoimmunity. Shaw MH, et al. Proc Natl Acad Sci U S A, 2003 Sep 30. PMID 14500783, Free PMC Article

See all (112) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Augmentative effects of leukemia inhibitory factor reveal a critical role for TYK2 signaling in vascular calcification.
    Title: Augmentative effects of leukemia inhibitory factor reveal a critical role for TYK2 signaling in vascular calcification.
  2. Tyrosine kinase 2 modulates splenic B cells through type I IFN and TLR7 signaling.
    Title: Tyrosine kinase 2 modulates splenic B cells through type I IFN and TLR7 signaling.
  3. TYK2 inhibition reduces type 3 immunity and modifies disease progression in murine spondyloarthritis.
    Title: TYK2 inhibition reduces type 3 immunity and modifies disease progression in murine spondyloarthritis.
  4. The study shows that poultry dust controls the induction of immune and inflammatory mediator expression via a cellular pathway involving oxidative stress-mediated STAT3 activation by TYK2 and EGFR tyrosine kinases.
    Title: Organic dust induces inflammatory gene expression in lung epithelial cells via ROS-dependent STAT-3 activation.
  5. our findings provide the first evidence, to our knowledge, for a key role of TYK2 in the host environment in promoting NK cell maturation and antitumor activity.
    Title: NK Cells Require Cell-Extrinsic and -Intrinsic TYK2 for Full Functionality in Tumor Surveillance and Antibacterial Immunity.
  6. TYK2(P) diminishes IL-12, IL-23, and IFN I signaling and that its protective effect is most likely manifest in the setting of autoimmune triggers that concurrently dysregulate at least two of these important signaling cascades.
    Title: The TYK2-P1104A Autoimmune Protective Variant Limits Coordinate Signals Required to Generate Specialized T Cell Subsets.
  7. TYK2 genetic variants are differentially associated with common autoimmune diseases
    Title: Resolving TYK2 locus genotype-to-phenotype differences in autoimmunity.
  8. Results show that loss of TYK2 does not affect disease severity of JAK2VF-induced murine myeloproliferative neoplasms (MPN) indicating that TYK2 has no cooperative effects with JAK2VF at the onset of MPN.
    Title: Loss of Tyrosine Kinase 2 Does Not Affect the Severity of Jak2V617F-induced Murine Myeloproliferative Neoplasm.
  9. mutated form which lacks tyrosine kinase activity restores differentiation of brown preadipocytes
    Title: Kinase Inactive Tyrosine Kinase (Tyk2) Supports Differentiation of Brown Fat Cells.
  10. Decreased Tyk2 expression in pancreatic beta cells due to mutation determines susceptibility to virus-induced diabetes mellitus.
    Title: Reduced Tyk2 gene expression in β-cells due to natural mutation determines susceptibility to virus-induced diabetes.
Submit: New GeneRIF Correction See all GeneRIFs (53)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables growth hormone receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables growth hormone receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables non-membrane spanning protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables type 1 angiotensin receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell population proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cell surface receptor signaling pathway via JAK-STAT ISO
Inferred from Sequence Orthology
more info
  
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in growth hormone receptor signaling pathway via JAK-STAT IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in immune response NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in interleukin-10-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in interleukin-12-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of NK T cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of NK T cell proliferation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of T cell proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of T cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of T-helper 17 type immune response NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of interleukin-17 production NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of natural killer cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of receptor signaling pathway via JAK-STAT ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of type II interferon production ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in type I interferon-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in type II interferon-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of interleukin-12 receptor complex NAS
Non-traceable Author Statement
more info
 PubMed 
part_of interleukin-23 receptor complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
non-receptor tyrosine-protein kinase TYK2
Names
tyrosine kinase TYK2
NP_001192241.1
NP_001408188.1
NP_061263.2
XP_006510555.1
XP_006510557.1
XP_030100315.1
XP_030100316.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001205312.2 → NP_001192241.1  non-receptor tyrosine-protein kinase TYK2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC163637
    Consensus CDS
    CCDS57656.1
    UniProtKB/TrEMBL
    E9QJS1, Q3U447
    Related
    ENSMUSP00000150354.2, ENSMUST00000216874.2
    Conserved Domains (7) summary
    smart00219
    Location:917 → 1189
    TyrKc; Tyrosine kinase, catalytic domain
    smart00295
    Location:45 → 299
    B41; Band 4.1 homologues
    cd05080
    Location:912 → 1194
    PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
    pfam07714
    Location:612 → 886
    Pkinase_Tyr; Protein tyrosine kinase
    cl15255
    Location:459 → 557
    SH2; Src homology 2 (SH2) domain
    cl17171
    Location:296 → 459
    PH-like; Pleckstrin homology-like domain
    cl21453
    Location:612 → 887
    PKc_like; Protein Kinases, catalytic domain

  2. NM_001421259.1 → NP_001408188.1  non-receptor tyrosine-protein kinase TYK2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC163637
    UniProtKB/Swiss-Prot
    O88431, Q3TXE3, Q52KQ2, Q8VE41, Q9R117

  3. NM_018793.3 → NP_061263.2  non-receptor tyrosine-protein kinase TYK2 isoform 2

    See identical proteins and their annotated locations for NP_061263.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC163637
    Consensus CDS
    CCDS90510.1
    UniProtKB/Swiss-Prot
    O88431, Q3TXE3, Q52KQ2, Q8VE41, Q9R117
    UniProtKB/TrEMBL
    Q3TIS9
    Related
    ENSMUSP00000150214.2, ENSMUST00000214454.2
    Conserved Domains (6) summary
    cd05080
    Location:889 → 1171
    PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
    pfam17887
    Location:288 → 431
    Jak1_Phl; Jak1 pleckstrin homology-like domain
    pfam18377
    Location:146 → 269
    FERM_F2; FERM F2 acyl-CoA binding protein-like domain
    pfam18379
    Location:33 → 128
    FERM_F1; FERM F1 ubiquitin-like domain
    cl15255
    Location:436 → 534
    SH2; Src homology 2 (SH2) domain
    cl21453
    Location:589 → 864
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    21015364..21042689 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030244455.1 → XP_030100315.1  non-receptor tyrosine-protein kinase TYK2 isoform X3

    UniProtKB/TrEMBL
    Q3TIS9
    Conserved Domains (5) summary
    cd05080
    Location:726 → 1008
    PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
    pfam17887
    Location:125 → 268
    Jak1_Phl; Jak1 pleckstrin homology-like domain
    pfam18377
    Location:2 → 106
    FERM_F2; FERM F2 acyl-CoA binding protein-like domain
    cl15255
    Location:273 → 371
    SH2; Src homology 2 (SH2) domain
    cl21453
    Location:426 → 701
    PKc_like; Protein Kinases, catalytic domain

  2. XM_006510492.4 → XP_006510555.1  non-receptor tyrosine-protein kinase TYK2 isoform X2

    UniProtKB/TrEMBL
    Q3TIS9
    Conserved Domains (6) summary
    cd05080
    Location:785 → 1067
    PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
    pfam17887
    Location:184 → 327
    Jak1_Phl; Jak1 pleckstrin homology-like domain
    pfam18377
    Location:104 → 165
    FERM_F2; FERM F2 acyl-CoA binding protein-like domain
    pfam18379
    Location:33 → 110
    FERM_F1; FERM F1 ubiquitin-like domain
    cl15255
    Location:332 → 430
    SH2; Src homology 2 (SH2) domain
    cl21453
    Location:485 → 760
    PKc_like; Protein Kinases, catalytic domain

  3. XM_030244456.1 → XP_030100316.1  non-receptor tyrosine-protein kinase TYK2 isoform X4

    Conserved Domains (4) summary
    cd10381
    Location:178 → 276
    SH2_Jak_Tyk2; Src homology 2 (SH2) domain in Tyrosine Kinase 2 (Tyk2), a member of the Janus kinases (JAK)
    cd05080
    Location:631 → 913
    PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
    pfam17887
    Location:30 → 173
    Jak1_Phl; Jak1 pleckstrin homology-like domain
    cl21453
    Location:331 → 606
    PKc_like; Protein Kinases, catalytic domain

  4. XM_006510494.2 → XP_006510557.1  non-receptor tyrosine-protein kinase TYK2 isoform X5

    Conserved Domains (5) summary
    pfam17887
    Location:288 → 431
    Jak1_Phl; Jak1 pleckstrin homology-like domain
    pfam18377
    Location:146 → 269
    FERM_F2; FERM F2 acyl-CoA binding protein-like domain
    pfam18379
    Location:33 → 128
    FERM_F1; FERM F1 ubiquitin-like domain
    cl15255
    Location:436 → 534
    SH2; Src homology 2 (SH2) domain
    cl21453
    Location:589 → 722
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_001778942.2 RNA Sequence

    Related
    ENSMUST00000213717.2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9R117.3 GenPept UniProtKB/Swiss-Prot:Q9R117

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