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TASOR2 transcription activation suppressor family member 2 [ Homo sapiens (human) ]

Gene ID: 54906, updated on 5-Mar-2024

Summary

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Official Symbol
TASOR2provided by HGNC
Official Full Name
transcription activation suppressor family member 2provided by HGNC
Primary source
HGNC:HGNC:23484
See related
Ensembl:ENSG00000108021 AllianceGenome:HGNC:23484
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAM208B; C10orf18; bA318E3.2
Summary
Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 8.3), thyroid (RPKM 5.1) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
10p15.1
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (5684838..5763740)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (5688634..5767529)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (5726801..5805703)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984199 Neighboring gene RNA, 7SL, cytoplasmic 445, pseudogene Neighboring gene ankyrin repeat and SOCS box containing 13 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:5702971-5703707 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2081 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2082 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2925 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2926 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2083 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2084 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2927 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2085 Neighboring gene Sharpr-MPRA regulatory region 2494 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:5793844-5794458 Neighboring gene MPRA-validated peak855 silencer Neighboring gene GDP dissociation inhibitor 2 Neighboring gene nuclear receptor binding factor 2 pseudogene 5 Neighboring gene uncharacterized LOC124902367 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:5854819-5855411

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Genome-wide association study identifies two susceptibility loci for osteosarcoma. Savage SA, et al. Nat Genet, 2013 Jul. PMID 23727862, Free PMC Article
  2. NFX1-123 and poly(A) binding proteins synergistically augment activation of telomerase in human papillomavirus type 16 E6-expressing cells. Katzenellenbogen RA, et al. J Virol, 2007 Apr. PMID 17267499, Free PMC Article
  3. Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method. Oshikawa M, et al. Invest Ophthalmol Vis Sci, 2011 Aug 22. PMID 21697133
  4. Systematic interactome mapping of acute lymphoblastic leukemia cancer gene products reveals EXT-1 tumor suppressor as a Notch1 and FBWX7 common interactor. Daakour S, et al. BMC Cancer, 2016 May 26. PMID 27229929, Free PMC Article
  5. Study of FOXO1-interacting proteins using TurboID-based proximity labeling technology. Su Y, et al. BMC Genomics, 2023 Mar 24. PMID 36964488, Free PMC Article

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies two susceptibility loci for osteosarcoma.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ20360, DKFZp781E1986

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of gene expression, epigenetic IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
protein TASOR 2
Names
family with sequence similarity 208 member B
protein FAM208B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021250.2 RefSeqGene

    Range
    5002..83904
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001321783.2 → NP_001308712.2  protein TASOR 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL365356, AL596094
    Consensus CDS
    CCDS41485.1
    UniProtKB/Swiss-Prot
    Q2YD91, Q5VWN5, Q5VWN6, Q6ZRQ8, Q8IVG4, Q9BUZ7, Q9H5J9, Q9H7A4, Q9H996, Q9NXA1
    UniProtKB/TrEMBL
    A0A8Q3SI68
    Related
    ENSP00000512130.1, ENST00000695737.1
    Conserved Domains (2) summary
    pfam12480
    Location:94 → 167
    DUF3699; Protein of unknown function (DUF3699)
    pfam12509
    Location:552 → 701
    DUF3715; Protein of unknown function (DUF3715)

  2. NM_001321784.2 → NP_001308713.2  protein TASOR 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL365356, AL596094
    Consensus CDS
    CCDS41485.1
    UniProtKB/Swiss-Prot
    Q2YD91, Q5VWN5, Q5VWN6, Q6ZRQ8, Q8IVG4, Q9BUZ7, Q9H5J9, Q9H7A4, Q9H996, Q9NXA1
    UniProtKB/TrEMBL
    A0A8Q3SI68
    Related
    ENSP00000512207.1, ENST00000695834.1
    Conserved Domains (2) summary
    pfam12480
    Location:94 → 167
    DUF3699; Protein of unknown function (DUF3699)
    pfam12509
    Location:552 → 701
    DUF3715; Protein of unknown function (DUF3715)

  3. NM_001321785.2 → NP_001308714.2  protein TASOR 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL365356, AL596094
    Consensus CDS
    CCDS91209.1
    UniProtKB/TrEMBL
    A0A8Q3SI68, A0A8Q3SI84
    Related
    ENSP00000512206.1, ENST00000695833.1
    Conserved Domains (2) summary
    pfam12480
    Location:94 → 167
    DUF3699; Protein of unknown function (DUF3699)
    pfam12509
    Location:471 → 620
    DUF3715; Protein of unknown function (DUF3715)

  4. NM_001387328.1 → NP_001374257.1  protein TASOR 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL365356, AL596094
    Consensus CDS
    CCDS91208.1
    UniProtKB/TrEMBL
    A0A2R8YH03, A0A8V8TMN1
    Related
    ENSP00000496466.1, ENST00000645567.1
    Conserved Domains (2) summary
    pfam12480
    Location:309 → 382
    DUF3699; Protein of unknown function (DUF3699)
    pfam12509
    Location:767 → 916
    DUF3715; Protein of unknown function (DUF3715)

  5. NM_017782.5 → NP_060252.5  protein TASOR 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL365356, AL596094
    Consensus CDS
    CCDS41485.1
    UniProtKB/Swiss-Prot
    Q2YD91, Q5VWN5, Q5VWN6, Q6ZRQ8, Q8IVG4, Q9BUZ7, Q9H5J9, Q9H7A4, Q9H996, Q9NXA1
    UniProtKB/TrEMBL
    A0A8Q3SI68
    Related
    ENSP00000328426.5, ENST00000328090.9
    Conserved Domains (2) summary
    pfam12480
    Location:94 → 167
    DUF3699; Protein of unknown function (DUF3699)
    pfam12509
    Location:552 → 701
    DUF3715; Protein of unknown function (DUF3715)

RNA

  1. NR_135800.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL365356, R42352

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    5684838..5763740
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    5688634..5767529
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5VWN6.1 GenPept UniProtKB/Swiss-Prot:Q5VWN6

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