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PARP16 poly(ADP-ribose) polymerase family member 16 [ Homo sapiens (human) ]

Gene ID: 54956, updated on 5-Mar-2024

Summary

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Official Symbol
PARP16provided by HGNC
Official Full Name
poly(ADP-ribose) polymerase family member 16provided by HGNC
Primary source
HGNC:HGNC:26040
See related
Ensembl:ENSG00000138617 MIM:620391; AllianceGenome:HGNC:26040
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARTD15; pART15; C15orf30
Summary
Enables kinase binding activity; pentosyltransferase activity; and protein serine/threonine kinase activator activity. Involved in several processes, including IRE1-mediated unfolded protein response; positive regulation of protein serine/threonine kinase activity; and protein ADP-ribosylation. Located in endoplasmic reticulum tubular network and nuclear envelope. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary (RPKM 4.7), endometrium (RPKM 3.3) and 25 other tissues See more
Orthologs
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Genomic context

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See PARP16 in Genome Data Viewer
Location:
15q22.31
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (65230917..65286883, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (63040296..63096236, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (65550437..65579221, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene cartilage intermediate layer protein Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:65504440-65505341 Neighboring gene RNA, U6 small nuclear 686, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:65532106-65532606 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:65532607-65533107 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:65545798-65546298 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6554 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9594 Neighboring gene small nucleolar RNA, H/ACA box 24B Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr15:65588516-65589427 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:65593529-65594044 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6555 Neighboring gene RNA, U5A small nuclear 1 Neighboring gene RNA, U5B small nuclear 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Poly (ADP-ribose) polymerases 16 triggers pathological cardiac hypertrophy via activating IRE1α-sXBP1-GATA4 pathway. Su H, et al. Cell Mol Life Sci, 2023 May 23. PMID 37219631, Free PMC Article
  2. Regulation of nucleocytoplasmic transport by ADP-ribosylation: the emerging role of karyopherin-β1 mono-ADP-ribosylation by ARTD15. Di Girolamo M. Curr Top Microbiol Immunol, 2015. PMID 25037261
  3. Regulation of poly ADP-ribosylation of VEGF by an interplay between PARP-16 and TNKS-2. Kunhiraman H, et al. Mol Cell Biochem, 2020 Aug. PMID 32472322
  4. Ribosome ADP-ribosylation inhibits translation and maintains proteostasis in cancers. Challa S, et al. Cell, 2021 Aug 19. PMID 34314702, Free PMC Article
  5. PARP16/ARTD15 is a novel endoplasmic-reticulum-associated mono-ADP-ribosyltransferase that interacts with, and modifies karyopherin-ß1. Di Paola S, et al. PLoS One, 2012. PMID 22701565, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Poly (ADP-ribose) polymerases 16 triggers pathological cardiac hypertrophy via activating IRE1alpha-sXBP1-GATA4 pathway.
    Title: Poly (ADP-ribose) polymerases 16 triggers pathological cardiac hypertrophy via activating IRE1α-sXBP1-GATA4 pathway.
  2. Regulation of poly ADP-ribosylation of VEGF by an interplay between PARP-16 and TNKS-2.
    Title: Regulation of poly ADP-ribosylation of VEGF by an interplay between PARP-16 and TNKS-2.
  3. ARTD15 plays role in nucleocytoplasmic shuttling, through karyopherin-beta1 mono-ADP-ribosylation. [review]
    Title: Regulation of nucleocytoplasmic transport by ADP-ribosylation: the emerging role of karyopherin-β1 mono-ADP-ribosylation by ARTD15.
  4. PARP16 is a tail-anchored endoplasmic reticulum protein required for the PERK- and IRE1alpha-mediated unfolded protein response.
    Title: PARP16 is a tail-anchored endoplasmic reticulum protein required for the PERK- and IRE1α-mediated unfolded protein response.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ20509, FLJ25281

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables NAD+ ADP-ribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NAD+ ADP-ribosyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables NAD+ ADP-ribosyltransferase activity TAS
Traceable Author Statement
more info
  
enables NAD+- protein-aspartate ADP-ribosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables NAD+- protein-lysine ADP-ribosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables NAD+-protein ADP-ribosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables NAD+-protein-glutamate ADP-ribosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine/threonine kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in IRE1-mediated unfolded protein response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in NAD biosynthesis via nicotinamide riboside salvage pathway TAS
Traceable Author Statement
more info
  
involved_in cellular response to leukemia inhibitory factor IEA
Inferred from Electronic Annotation
more info
  
involved_in endoplasmic reticulum unfolded protein response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum unfolded protein response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cytoplasmic translation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein auto-ADP-ribosylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein auto-ADP-ribosylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in viral protein processing TAS
Traceable Author Statement
more info
  
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in endoplasmic reticulum IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum tubular network IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum tubular network IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in membrane HDA PubMed 
is_active_in nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
protein mono-ADP-ribosyltransferase PARP16
Names
ADP-ribosyltransferase diphtheria toxin-like 15
PARP-16
mono [ADP-ribose] polymerase PARP16
poly [ADP-ribose] polymerase 16
NP_001303872.1
NP_001303873.1
NP_060321.3
XP_006720652.1
XP_006720653.1
XP_006720655.1
XP_011520044.1
XP_016877875.1
XP_016877876.1
XP_016877877.1
XP_016877878.1
XP_024305737.1
XP_024305738.1
XP_047288731.1
XP_047288732.1
XP_047288733.1
XP_047288734.1
XP_054234305.1
XP_054234306.1
XP_054234307.1
XP_054234308.1
XP_054234309.1
XP_054234310.1
XP_054234311.1
XP_054234312.1
XP_054234313.1
XP_054234314.1
XP_054234315.1
XP_054234316.1
XP_054234317.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001316943.2 → NP_001303872.1  protein mono-ADP-ribosyltransferase PARP16 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction in the 3' end compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
    Source sequence(s)
    AC068213, AK000516, BC031074, DA110379
    Consensus CDS
    CCDS92018.1
    UniProtKB/Swiss-Prot
    A0A024R5Y7, Q6PK64, Q8N5Y8, Q9NX03
    Related
    ENSP00000496935.1, ENST00000649807.2
    Conserved Domains (2) summary
    pfam00644
    Location:95 → 273
    PARP; Poly(ADP-ribose) polymerase catalytic domain
    cl00283
    Location:150 → 259
    ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...

  2. NM_001316944.2 → NP_001303873.1  protein mono-ADP-ribosyltransferase PARP16 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons and uses an alternate in-frame splice junction at the 3' end compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC068213, AK000516
    Consensus CDS
    CCDS81897.1
    UniProtKB/Swiss-Prot
    Q8N5Y8
    UniProtKB/TrEMBL
    A0A024R5Y7
    Related
    ENSP00000396118.2, ENST00000444347.2
    Conserved Domains (2) summary
    pfam00644
    Location:61 → 158
    PARP; Poly(ADP-ribose) polymerase catalytic domain
    pfam18084
    Location:11 → 64
    ARTD15_N; ARTD15 N-terminal domain

  3. NM_017851.6 → NP_060321.3  protein mono-ADP-ribosyltransferase PARP16 isoform 1

    See identical proteins and their annotated locations for NP_060321.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC068213, AK000516, BC006389, DA110379
    Consensus CDS
    CCDS10204.1
    UniProtKB/Swiss-Prot
    Q8N5Y8
    Related
    ENSP00000261888.6, ENST00000261888.10
    Conserved Domains (1) summary
    pfam00644
    Location:95 → 273
    PARP; Poly(ADP-ribose) polymerase catalytic domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    65230917..65286883 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047432777.1 → XP_047288733.1  protein mono-ADP-ribosyltransferase PARP16 isoform X7

  2. XM_047432778.1 → XP_047288734.1  protein mono-ADP-ribosyltransferase PARP16 isoform X13

  3. XM_006720590.4 → XP_006720653.1  protein mono-ADP-ribosyltransferase PARP16 isoform X2

    Conserved Domains (2) summary
    pfam00644
    Location:102 → 273
    PARP; Poly(ADP-ribose) polymerase catalytic domain
    pfam18084
    Location:11 → 90
    ARTD15_N; ARTD15 N-terminal domain

  4. XM_006720589.4 → XP_006720652.1  protein mono-ADP-ribosyltransferase PARP16 isoform X1

    Conserved Domains (2) summary
    pfam00644
    Location:102 → 273
    PARP; Poly(ADP-ribose) polymerase catalytic domain
    pfam18084
    Location:11 → 90
    ARTD15_N; ARTD15 N-terminal domain

  5. XM_047432775.1 → XP_047288731.1  protein mono-ADP-ribosyltransferase PARP16 isoform X3

  6. XM_047432776.1 → XP_047288732.1  protein mono-ADP-ribosyltransferase PARP16 isoform X4

  7. XM_024449969.2 → XP_024305737.1  protein mono-ADP-ribosyltransferase PARP16 isoform X10

    Conserved Domains (2) summary
    pfam00644
    Location:59 → 227
    PARP; Poly(ADP-ribose) polymerase catalytic domain
    pfam18084
    Location:11 → 66
    ARTD15_N; ARTD15 N-terminal domain

  8. XM_024449970.2 → XP_024305738.1  protein mono-ADP-ribosyltransferase PARP16 isoform X14

    Conserved Domains (2) summary
    pfam00644
    Location:108 → 204
    PARP; Poly(ADP-ribose) polymerase catalytic domain
    pfam18084
    Location:11 → 90
    ARTD15_N; ARTD15 N-terminal domain

  9. XM_017022387.3 → XP_016877876.1  protein mono-ADP-ribosyltransferase PARP16 isoform X9

    Conserved Domains (2) summary
    pfam00644
    Location:59 → 227
    PARP; Poly(ADP-ribose) polymerase catalytic domain
    pfam18084
    Location:11 → 65
    ARTD15_N; ARTD15 N-terminal domain

  10. XM_011521742.4 → XP_011520044.1  protein mono-ADP-ribosyltransferase PARP16 isoform X8

    Conserved Domains (2) summary
    pfam00644
    Location:59 → 227
    PARP; Poly(ADP-ribose) polymerase catalytic domain
    pfam18084
    Location:11 → 66
    ARTD15_N; ARTD15 N-terminal domain

  11. XM_017022386.3 → XP_016877875.1  protein mono-ADP-ribosyltransferase PARP16 isoform X6

    Conserved Domains (1) summary
    cl00283
    Location:131 → 240
    ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...

  12. XM_006720592.4 → XP_006720655.1  protein mono-ADP-ribosyltransferase PARP16 isoform X5

    See identical proteins and their annotated locations for XP_006720655.1

    Conserved Domains (2) summary
    pfam00644
    Location:86 → 254
    PARP; Poly(ADP-ribose) polymerase catalytic domain
    pfam18084
    Location:11 → 85
    ARTD15_N; ARTD15 N-terminal domain

  13. XM_017022389.3 → XP_016877878.1  protein mono-ADP-ribosyltransferase PARP16 isoform X12

    Conserved Domains (2) summary
    pfam00644
    Location:108 → 204
    PARP; Poly(ADP-ribose) polymerase catalytic domain
    pfam18084
    Location:11 → 90
    ARTD15_N; ARTD15 N-terminal domain

  14. XM_017022388.3 → XP_016877877.1  protein mono-ADP-ribosyltransferase PARP16 isoform X11

    Conserved Domains (2) summary
    pfam00644
    Location:108 → 204
    PARP; Poly(ADP-ribose) polymerase catalytic domain
    pfam18084
    Location:11 → 90
    ARTD15_N; ARTD15 N-terminal domain

RNA

  1. XR_007064469.1 RNA Sequence

  2. XR_001751341.3 RNA Sequence

  3. XR_001751342.3 RNA Sequence

  4. XR_429460.4 RNA Sequence

  5. XR_429459.4 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    63040296..63096236 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054378335.1 → XP_054234310.1  protein mono-ADP-ribosyltransferase PARP16 isoform X7

  2. XM_054378341.1 → XP_054234316.1  protein mono-ADP-ribosyltransferase PARP16 isoform X13

  3. XM_054378331.1 → XP_054234306.1  protein mono-ADP-ribosyltransferase PARP16 isoform X2

  4. XM_054378330.1 → XP_054234305.1  protein mono-ADP-ribosyltransferase PARP16 isoform X1

  5. XM_054378332.1 → XP_054234307.1  protein mono-ADP-ribosyltransferase PARP16 isoform X4

  6. XM_054378338.1 → XP_054234313.1  protein mono-ADP-ribosyltransferase PARP16 isoform X10

  7. XM_054378342.1 → XP_054234317.1  protein mono-ADP-ribosyltransferase PARP16 isoform X14

  8. XM_054378337.1 → XP_054234312.1  protein mono-ADP-ribosyltransferase PARP16 isoform X9

  9. XM_054378336.1 → XP_054234311.1  protein mono-ADP-ribosyltransferase PARP16 isoform X8

  10. XM_054378334.1 → XP_054234309.1  protein mono-ADP-ribosyltransferase PARP16 isoform X6

  11. XM_054378333.1 → XP_054234308.1  protein mono-ADP-ribosyltransferase PARP16 isoform X5

  12. XM_054378340.1 → XP_054234315.1  protein mono-ADP-ribosyltransferase PARP16 isoform X12

  13. XM_054378339.1 → XP_054234314.1  protein mono-ADP-ribosyltransferase PARP16 isoform X11

RNA

  1. XR_008488981.1 RNA Sequence

  2. XR_008488977.1 RNA Sequence

  3. XR_008488979.1 RNA Sequence

  4. XR_008488980.1 RNA Sequence

  5. XR_008488978.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N5Y8.2 GenPept UniProtKB/Swiss-Prot:Q8N5Y8

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