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ADISSP adipose secreted signaling protein [ Homo sapiens (human) ]

Gene ID: 54976, updated on 3-Apr-2024

Summary

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Official Symbol
ADISSPprovided by HGNC
Official Full Name
adipose secreted signaling proteinprovided by HGNC
Primary source
HGNC:HGNC:15873
See related
Ensembl:ENSG00000101220 MIM:620373; AllianceGenome:HGNC:15873
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C20orf27
Summary
Enables protein phosphatase 1 binding activity. Involved in positive regulation of NIK/NF-kappaB signaling and positive regulation of transforming growth factor beta receptor signaling pathway. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bone marrow (RPKM 20.0), fat (RPKM 18.1) and 24 other tissues See more
Orthologs
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Genomic context

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Location:
20p13
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (3753508..3768388, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (3784462..3799327, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (3734155..3749035, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene sialic acid binding Ig like lectin 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:3678505-3679004 Neighboring gene Sharpr-MPRA regulatory region 3812 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12624 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_60092 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:3713394-3713973 Neighboring gene heat shock protein family A (Hsp70) member 12B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:3722898-3723425 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:3725082-3725992 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:3729440-3729992 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:3729993-3730543 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:3747545-3748309 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:3748437-3749023 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17482 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12627 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:3759113-3759730 Neighboring gene Sharpr-MPRA regulatory region 2213 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:3766083-3766793 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:3766794-3767503 Neighboring gene sperm flagellar 1 Neighboring gene centromere protein B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. C20orf27 Promotes Cell Growth and Proliferation of Colorectal Cancer via the TGFβR-TAK1-NFĸB Pathway. Gao J, et al. Cancers (Basel), 2020 Feb 2. PMID 32024300, Free PMC Article
  2. A brown fat-enriched adipokine Adissp controls adipose thermogenesis and glucose homeostasis. Chen Q, et al. Nat Commun, 2022 Dec 10. PMID 36496438, Free PMC Article
  3. The SARS-coronavirus-host interactome: identification of cyclophilins as target for pan-coronavirus inhibitors. Pfefferle S, et al. PLoS Pathog, 2011 Oct. PMID 22046132, Free PMC Article
  4. The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1. Giannone RJ, et al. PLoS One, 2010 Aug 25. PMID 20811636, Free PMC Article
  5. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. Gevaert K, et al. Nat Biotechnol, 2003 May. PMID 12665801

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
  2. Observational study of gene-disease association. (HuGE Navigator)
    Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ20550

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein phosphatase 1 binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in adaptive thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in glucose homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of non-canonical NF-kappaB signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein kinase A signaling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of transforming growth factor beta receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
adipose-secreted signaling protein
Names
UPF0687 protein C20orf27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039140.3 → NP_001034229.1  adipose-secreted signaling protein isoform 1

    See identical proteins and their annotated locations for NP_001034229.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK024220, BF978883, BG474804, DB317576
    Consensus CDS
    CCDS33436.1
    UniProtKB/Swiss-Prot
    Q9GZN8
    Related
    ENSP00000217195.8, ENST00000217195.12
    Conserved Domains (1) summary
    pfam15006
    Location:53 → 198
    DUF4517; Domain of unknown function (DUF4517)

  2. NM_001258429.2 → NP_001245358.1  adipose-secreted signaling protein isoform 2

    See identical proteins and their annotated locations for NP_001245358.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the coding region, but maintains the reading frame, compared to variant 1. Variants 2 and 3 encode the same isoform (2), which is shorter than isoform 1.
    Source sequence(s)
    AK024220, BF978883, DB317576
    Consensus CDS
    CCDS58763.1
    UniProtKB/Swiss-Prot
    A8K4J0, D3DVX8, Q5JX81, Q9GZN8, Q9NWX3
    Related
    ENSP00000369097.4, ENST00000379772.4
    Conserved Domains (1) summary
    pfam15006
    Location:28 → 173
    DUF4517; Domain of unknown function (DUF4517)

  3. NM_001258430.2 → NP_001245359.1  adipose-secreted signaling protein isoform 2

    See identical proteins and their annotated locations for NP_001245359.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate splice site in the coding region, but maintains the reading frame, compared to variant 1. Variants 2 and 3 encoded the same isoform (2), which is shorter than isoform 1.
    Source sequence(s)
    AK024220, BC069204, DB317576
    Consensus CDS
    CCDS58763.1
    UniProtKB/Swiss-Prot
    A8K4J0, D3DVX8, Q5JX81, Q9GZN8, Q9NWX3
    Related
    ENSP00000382580.1, ENST00000399672.5
    Conserved Domains (1) summary
    pfam15006
    Location:28 → 173
    DUF4517; Domain of unknown function (DUF4517)

RNA

  1. NR_047675.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate 5'-most exon and an alternate splice site, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK290955, AL109804, DB317576

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    3753508..3768388 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047440245.1 → XP_047296201.1  adipose-secreted signaling protein isoform X2

    Related
    ENSP00000382591.3, ENST00000399683.7

  2. XM_011529266.4 → XP_011527568.1  adipose-secreted signaling protein isoform X1

    Conserved Domains (1) summary
    pfam15006
    Location:53 → 157
    DUF4517; Domain of unknown function (DUF4517)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    3784462..3799327 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054323584.1 → XP_054179559.1  adipose-secreted signaling protein isoform X2

  2. XM_054323583.1 → XP_054179558.1  adipose-secreted signaling protein isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_017874.2: Suppressed sequence

    Description
    NM_017874.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9GZN8.3 GenPept UniProtKB/Swiss-Prot:Q9GZN8

Gene LinkOut

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