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PLAAT2 phospholipase A and acyltransferase 2 [ Homo sapiens (human) ]

Gene ID: 54979, updated on 5-Mar-2024

Summary

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Official Symbol
PLAAT2provided by HGNC
Official Full Name
phospholipase A and acyltransferase 2provided by HGNC
Primary source
HGNC:HGNC:17824
See related
Ensembl:ENSG00000133328 MIM:613866; AllianceGenome:HGNC:17824
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HRASLS2; PLAAT-2; PLA1/2-2
Summary
The protein encoded by this gene has both phospholipase and acyltransferase activities and acts as a tumor suppressor. The encoded protein can hydrolyze dipalmitoylated phosphatidylcholine (PC) to palmitic acid and lyso-PC. In addition, this protein can catalyze the N-acylation of phosphatidylethanolamine and can catalyze the O-acylation of lyso-PC to form PC. [provided by RefSeq, Jul 2016]
Expression
Biased expression in duodenum (RPKM 16.4), small intestine (RPKM 9.9) and 3 other tissues See more
Orthologs
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Genomic context

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Location:
11q12.3
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (63552770..63565070, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (63542032..63554332, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (63320242..63330851, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:63295415-63296076 Neighboring gene TMSB4X pseudogene 5 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:63296739-63297398 Neighboring gene Sharpr-MPRA regulatory region 8142 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:63299385-63300044 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4869 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4870 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:63312621-63313820 Neighboring gene phospholipase A and acyltransferase 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4871 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3435 Neighboring gene CRISPRi-validated cis-regulatory element chr11.2897 Neighboring gene uncharacterized LOC105369335 Neighboring gene phospholipase A and acyltransferase 3 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:63368875-63369376 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:63372619-63373384 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:63378198-63378707 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:63379461-63379961 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3436 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3437 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:63398741-63399940 Neighboring gene inner mitochondrial membrane peptidase subunit 1 pseudogene 1 Neighboring gene atlastin GTPase 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Cloning and functional characterization of the HRASLS2 gene. Shyu RY, et al. Amino Acids, 2008 Jun. PMID 18163183
  2. Structural basis for the acyltransferase activity of lecithin:retinol acyltransferase-like proteins. Golczak M, et al. J Biol Chem, 2012 Jul 6. PMID 22605381, Free PMC Article
  3. Characterization of the human tumor suppressors TIG3 and HRASLS2 as phospholipid-metabolizing enzymes. Uyama T, et al. Biochim Biophys Acta, 2009 Dec. PMID 19615464
  4. Generation of N-acylphosphatidylethanolamine by members of the phospholipase A/acyltransferase (PLA/AT) family. Uyama T, et al. J Biol Chem, 2012 Sep 14. PMID 22825852, Free PMC Article
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. Bailey SD, et al. Diabetes Care, 2010 Oct. PMID 20628086, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that acyl-modified forms of HRAS-like tumor suppressors HRASLS2 and HRASLS3 mimicking lipolytic activity of lecithin retinol acyltransferase LRAT.
    Title: Structural basis for the acyltransferase activity of lecithin:retinol acyltransferase-like proteins.
  2. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
  3. Observational study of gene-disease association. (HuGE Navigator)
    Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
  4. The tumor suppressors TIG3, HRASLS2 and H-rev107 are involved in the phospholipid metabolism with different physiological roles.
    Title: Characterization of the human tumor suppressors TIG3 and HRASLS2 as phospholipid-metabolizing enzymes.
  5. HRASLS2 protein suppressed growth and RAS activities of cancer cells, and the C-terminal hydrophobic domain appeared to be indispensable for both activities.
    Title: Cloning and functional characterization of the HRASLS2 gene.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • FLJ20556

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 1-acyl-2-lysophosphatidylserine acylhydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables N-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables N-acyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables acyltransferase activity TAS
Traceable Author Statement
more info
  
enables phosphatidylserine 1-acylhydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables phospholipase A1 activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phospholipase A1 activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phospholipase A2 activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phospholipase A2 activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in N-acylphosphatidylethanolamine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in N-acylphosphatidylethanolamine metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in localization EXP
Inferred from Experiment
more info
 PubMed 
involved_in phosphatidylethanolamine acyl-chain remodeling TAS
Traceable Author Statement
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
phospholipase A and acyltransferase 2
Names
HRAS like suppressor 2
phospholipase A/acyltransferase-2
NP_060348.1
XP_011543422.1
XP_054225195.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017878.2 → NP_060348.1  phospholipase A and acyltransferase 2

    See identical proteins and their annotated locations for NP_060348.1

    Status: REVIEWED

    Source sequence(s)
    AK000563
    Consensus CDS
    CCDS8046.1
    UniProtKB/Swiss-Prot
    B9A7L8, Q9NWW9
    Related
    ENSP00000255695.1, ENST00000255695.2
    Conserved Domains (1) summary
    pfam04970
    Location:20 → 125
    LRAT; Lecithin retinol acyltransferase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    63552770..63565070 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011545120.3 → XP_011543422.1  phospholipase A and acyltransferase 2 isoform X1

    See identical proteins and their annotated locations for XP_011543422.1

    Conserved Domains (1) summary
    pfam04970
    Location:53 → 158
    LRAT; Lecithin retinol acyltransferase

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    63542032..63554332 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054369220.1 → XP_054225195.1  phospholipase A and acyltransferase 2 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NWW9.1 GenPept UniProtKB/Swiss-Prot:Q9NWW9

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