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1ab ORF1ab polyprotein [ Duck coronavirus ]

Gene ID: 55060258, updated on 29-Jul-2022

Summary

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Gene symbol
1ab
Gene description
ORF1ab polyprotein
Locus tag
HO267_gp01
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Duck coronavirus (isolate: DK/GD/27/2014, nat-host: duck)
Lineage
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes; Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae; Gammacoronavirus; Igacovirus
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Genomic context

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Sequence:
NC_048214.1 (347..20364)

NC_048214.1Genomic Context describing neighboring genes Neighboring gene ORF1a polyprotein Neighboring gene spike protein Neighboring gene 3a protein Neighboring gene 3b protein Neighboring gene 3c protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_048214.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genomic Analysis and Surveillance of the Coronavirus Dominant in Ducks in China. Zhuang QY, et al. PLoS One, 2015. PMID 26053682, Free PMC Article

GeneRIFs: Gene References Into Functions

General protein information

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Preferred Names
ORF1ab polyprotein
Names
polyprotein pp1ab
NSP13
NSP14
NSP15
NSP16
NSP12
YP_009825006.1
  • ORF1ab polyprotein is cleaved to yield the RNA-dependent RNA polymerase and other nonstructural proteins

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_048214.1 Reference assembly

    Range
    347..20364
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_009825006.1 ORF1ab polyprotein [Duck coronavirus]

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A0F6WGL5
    Conserved Domains (24) summary
    cd21401
    Location:4912 → 5006
    ZBD_cv_Nsp13-like; Cys/His rich zinc-binding domain (CH/ZBD) of coronavirus SARS NSP13 helicase and related proteins
    cd21409
    Location:5061 → 5139
    1B_cv_Nsp13-like; 1B domain of coronavirus SARS NSP13 helicase and related proteins
    cd21473
    Location:2304 → 2701
    cv_Nsp4_TM; coronavirus non-structural protein 4 (Nsp4) transmembrane domain
    cd21512
    Location:35 → 368
    cv_gamma-delta_Nsp2_IBV-like; gamma- and deltacoronavirus non-structural protein 2 (Nsp2), similar to IBV Nsp2 and related proteins
    cd21559
    Location:3103 → 3409
    gammaCoV-Nsp6; gammacoronavirus non-structural protein 6
    cd21557
    Location:1060 → 1186
    Macro_X_Nsp3-like; X-domain of viral non-structural protein 3 and related macrodomains
    cd21667
    Location:2810 → 3115
    gammaCoV_Nsp5_Mpro; gammacoronavirus non-structural protein 5, also called Main protease (Mpro)
    cd21587
    Location:3968 → 4911
    gammaCoV_RdRp; gammacoronavirus RNA-dependent RNA polymerase, also known as non-structural protein 12: responsible for replication and transcription of the viral RNA genome
    cd21170
    Location:6035 → 6094
    NTD_cv_Nsp15-like; N-terminal domain of coronavirus Nonstructural protein 15 (Nsp15) and related proteins
    cd21168
    Location:6098 → 6219
    M_gcv_Nsp15-like; middle domain of gammacoronavirus Nonstructural protein 15 (Nsp15), and related proteins
    cd21658
    Location:5513 → 6031
    gammaCoV_Nsp14; nonstructural protein 14 of gammacoronavirus
    pfam06460
    Location:6372 → 6671
    NSP13; Coronavirus NSP13
    pfam16348
    Location:2716 → 2805
    Corona_NSP4_C; Coronavirus nonstructural protein 4 C-terminus
    cd21828
    Location:3410 → 3492
    gammaCoV_Nsp7; gammacoronavirus non-structural protein 7
    cd21832
    Location:3493 → 3702
    gammaCoV_Nsp8; gammacoronavirus non-structural protein 8
    cd21902
    Location:3815 → 3948
    gammaCoV_Nsp10; gammacoronavirus non-structural protein 10
    cd21899
    Location:3701 → 3813
    gammaCoV_Nsp9; gammacoronavirus non-structural protein 9
    cd21733
    Location:1198 → 1500
    gammaCoV_PLPro; gammacoronavirus papain-like protease
    cd21720
    Location:5162 → 5504
    gammaCoV_Nsp13-helicase; helicase domain of gammacoronavirus non-structural protein 13
    cd21710
    Location:1765 → 2293
    TM_Y_gammaCoV_Nsp3_C; C-terminus of gammacoronavirus non-structural protein 3, including transmembrane and Y domains
    cd21689
    Location:5010 → 5057
    stalk_CoV_Nsp13-like; stalk domain of coronavirus Nsp13 helicase and related proteins
    NF033839
    Location:861 → 1033
    PspC_subgroup_2; pneumococcal surface protein PspC, LPXTG-anchored form
    cl28922
    Location:696 → 779
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    cl41718
    Location:6218 → 6369
    NendoU_XendoU-like; Nidoviral uridylate-specific endoribonuclease (NendoU) domain of coronavirus Nonstructural protein 15 (Nsp15), arterivirus Nsp11, torovirus endoribonuclease, Xenopus laevis endoribonuclease XendoU, and related proteins

  2. YP_009825025.1 NSP13

    Conserved Domains (4) summary
    cd21401
    Location:1 → 94
    ZBD_cv_Nsp13-like; Cys/His rich zinc-binding domain (CH/ZBD) of coronavirus SARS NSP13 helicase and related proteins
    cd21409
    Location:149 → 227
    1B_cv_Nsp13-like; 1B domain of coronavirus SARS NSP13 helicase and related proteins
    cd21720
    Location:250 → 592
    gammaCoV_Nsp13-helicase; helicase domain of gammacoronavirus non-structural protein 13
    cd21689
    Location:98 → 145
    stalk_CoV_Nsp13-like; stalk domain of coronavirus Nsp13 helicase and related proteins

  3. YP_009825026.1 NSP14

    Conserved Domains (1) summary
    cd21658
    Location:1 → 519
    gammaCoV_Nsp14; nonstructural protein 14 of gammacoronavirus

  4. YP_009825027.1 NSP15

    Conserved Domains (3) summary
    cd21170
    Location:1 → 60
    NTD_cv_Nsp15-like; N-terminal domain of coronavirus Nonstructural protein 15 (Nsp15) and related proteins
    cd21168
    Location:64 → 185
    M_gcv_Nsp15-like; middle domain of gammacoronavirus Nonstructural protein 15 (Nsp15), and related proteins
    cl41718
    Location:184 → 335
    NendoU_XendoU-like; Nidoviral uridylate-specific endoribonuclease (NendoU) domain of coronavirus Nonstructural protein 15 (Nsp15), arterivirus Nsp11, torovirus endoribonuclease, Xenopus laevis endoribonuclease XendoU, and related proteins

  5. YP_009825028.1 NSP16

    Conserved Domains (1) summary
    pfam06460
    Location:1 → 277
    NSP13; Coronavirus NSP13

  6. YP_009825029.1 NSP12

    Conserved Domains (1) summary
    cd21587
    Location:10 → 953
    gammaCoV_RdRp; gammacoronavirus RNA-dependent RNA polymerase, also known as non-structural protein 12: responsible for replication and transcription of the viral RNA genome
Nucleotide Protein
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