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ZCWPW1 zinc finger CW-type and PWWP domain containing 1 [ Homo sapiens (human) ]

Gene ID: 55063, updated on 2-Nov-2024

Summary

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Official Symbol
ZCWPW1provided by HGNC
Official Full Name
zinc finger CW-type and PWWP domain containing 1provided by HGNC
Primary source
HGNC:HGNC:23486
See related
Ensembl:ENSG00000078487 MIM:618900; AllianceGenome:HGNC:23486
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZCW1
Summary
Enables histone reader activity; methyl-CpG binding activity; and methylated histone binding activity. Predicted to be involved in meiosis I; positive regulation of DNA metabolic process; and spermatogenesis. Predicted to act upstream of or within homologous chromosome pairing at meiosis. Predicted to be located in XY body. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in testis (RPKM 25.2), thyroid (RPKM 2.9) and 16 other tissues See more
Orthologs
mouse all
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Genomic context

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See ZCWPW1 in Genome Data Viewer
Location:
7q22.1
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (100400872..100428703, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (101640949..101668781, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (99998495..100026326, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene STAG3L5P-PVRIG2P-PILRB readthrough Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26356 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26357 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26358 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26359 Neighboring gene paired immunoglobin like type 2 receptor beta Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:99968027-99968778 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26360 Neighboring gene paired immunoglobin like type 2 receptor alpha Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26361 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:99995395-99995894 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26362 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18431 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26363 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26364 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18432 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26365 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18433 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:100034207-100034710 Neighboring gene PPP1R35 antisense RNA 1 Neighboring gene methylphosphate capping enzyme Neighboring gene protein phosphatase 1 regulatory subunit 35

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The histone modification reader ZCWPW1 promotes double-strand break repair by regulating cross-talk of histone modifications and chromatin accessibility at meiotic hotspots. Yuan S, et al. Genome Biol, 2022 Sep 6. PMID 36068616, Free PMC Article
  2. A loss-of-function variant in ZCWPW1 causes human male infertility with sperm head defect and high DNA fragmentation. Song Y, et al. Reprod Health, 2024 Feb 3. PMID 38310235, Free PMC Article
  3. Structural insight into the zinc finger CW domain as a histone modification reader. He F, et al. Structure, 2010 Sep 8. PMID 20826339
  4. ZCWPW1 is associated with late-onset Alzheimer's disease in Han Chinese: a replication study and meta-analyses. Gao Y, et al. Oncotarget, 2016 Apr 12. PMID 26958812, Free PMC Article
  5. Alzheimer's Disease Risk Polymorphisms Regulate Gene Expression in the ZCWPW1 and the CELF1 Loci. Karch CM, et al. PLoS One, 2016. PMID 26919393, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A loss-of-function variant in ZCWPW1 causes human male infertility with sperm head defect and high DNA fragmentation.
    Title: A loss-of-function variant in ZCWPW1 causes human male infertility with sperm head defect and high DNA fragmentation.
  2. The histone modification reader ZCWPW1 promotes double-strand break repair by regulating cross-talk of histone modifications and chromatin accessibility at meiotic hotspots.
    Title: The histone modification reader ZCWPW1 promotes double-strand break repair by regulating cross-talk of histone modifications and chromatin accessibility at meiotic hotspots.
  3. PRDM9 losses in vertebrates are coupled to those of paralogs ZCWPW1 and ZCWPW2.
    Title: PRDM9 losses in vertebrates are coupled to those of paralogs ZCWPW1 and ZCWPW2.
  4. ZCWPW1 is recruited to recombination hotspots by PRDM9 and is essential for meiotic double strand break repair.
    Title: ZCWPW1 is recruited to recombination hotspots by PRDM9 and is essential for meiotic double strand break repair.
  5. rs1476679 polymorphism in ZCWPW1 is associated with late-onset Alzheimer's disease.
    Title: ZCWPW1 is associated with late-onset Alzheimer's disease in Han Chinese: a replication study and meta-analyses.
  6. PILRB and GATS expression levels, within the ZCWPW1 locus, were associated with Alzheimer's disease status.
    Title: Alzheimer's Disease Risk Polymorphisms Regulate Gene Expression in the ZCWPW1 and the CELF1 Loci.
  7. Of those 394 variants, 34 showed strong evidence of regulatory function (RegulomeDB score <3), and only 3 of them were genome-wide significant SNPs (ZCWPW1/rs1476679, CLU/rs1532278 and ABCA7/rs3764650).
    Title: Connecting the dots: potential of data integration to identify regulatory SNPs in late-onset Alzheimer's disease GWAS findings.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
An atlas of genetic influences on human blood metabolites.
EBI GWAS Catalog
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ10057, DKFZp434N0510

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables histone reader activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables methyl-CpG binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables methylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methylated histone binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables methylated histone binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables methylated histone binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within homologous chromosome pairing at meiosis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in homologous chromosome pairing at meiosis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in meiosis I ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of DNA recombination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of double-strand break repair ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in spermatogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
zinc finger CW-type PWWP domain protein 1
Names
zinc finger CW-type and PWWP domain 1
zinc finger, CW-type with PWWP domain 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001258008.3 → NP_001244937.1  zinc finger CW-type PWWP domain protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001244937.1

    Status: VALIDATED

    Source sequence(s)
    AC005071, AC092849
    Consensus CDS
    CCDS59067.1
    UniProtKB/Swiss-Prot
    Q9H0M4
    Related
    ENSP00000354210.4, ENST00000360951.8
    Conserved Domains (2) summary
    pfam07496
    Location:256 → 302
    zf-CW; CW-type Zinc Finger
    cl02554
    Location:314 → 417
    PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...

  2. NM_001386008.1 → NP_001372937.1  zinc finger CW-type PWWP domain protein 1 isoform 14

    Status: VALIDATED

    Source sequence(s)
    AC005071, AC092849
    Conserved Domains (1) summary
    cl02554
    Location:85 → 155
    PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...

  3. NM_001386009.1 → NP_001372938.1  zinc finger CW-type PWWP domain protein 1 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC005071, AC092849
    UniProtKB/TrEMBL
    A0A0S2Z5K5
    Conserved Domains (2) summary
    pfam07496
    Location:188 → 234
    zf-CW; CW-type Zinc Finger
    cl02554
    Location:246 → 349
    PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...

  4. NM_001386010.1 → NP_001372939.1  zinc finger CW-type PWWP domain protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC005071, AC092849
    Consensus CDS
    CCDS94155.1
    UniProtKB/TrEMBL
    A0A804HK41, B4DXS7
    Related
    ENSP00000507762.1, ENST00000684423.1
    Conserved Domains (2) summary
    cd05837
    Location:314 → 417
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    pfam07496
    Location:256 → 302
    zf-CW; CW-type Zinc Finger

  5. NM_001386011.1 → NP_001372940.1  zinc finger CW-type PWWP domain protein 1 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC005071, AC092849
    Conserved Domains (2) summary
    pfam07496
    Location:125 → 171
    zf-CW; CW-type Zinc Finger
    cl02554
    Location:183 → 286
    PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...

  6. NM_001386012.1 → NP_001372941.1  zinc finger CW-type PWWP domain protein 1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC005071, AC092849
    UniProtKB/TrEMBL
    B4DXS7
    Conserved Domains (2) summary
    cd05837
    Location:183 → 286
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    pfam07496
    Location:125 → 171
    zf-CW; CW-type Zinc Finger

  7. NM_001386013.1 → NP_001372942.1  zinc finger CW-type PWWP domain protein 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC005071, AC092849
    Conserved Domains (2) summary
    pfam07496
    Location:256 → 303
    zf-CW; CW-type Zinc Finger
    cl02554
    Location:315 → 418
    PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...

  8. NM_001386015.1 → NP_001372944.1  zinc finger CW-type PWWP domain protein 1 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC005071, AC092849
    UniProtKB/TrEMBL
    A0A0S2Z5J5
    Conserved Domains (2) summary
    cd05837
    Location:113 → 216
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    pfam07496
    Location:55 → 101
    zf-CW; CW-type Zinc Finger

  9. NM_001386016.1 → NP_001372945.1  zinc finger CW-type PWWP domain protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC005071, AC092849
    UniProtKB/TrEMBL
    B4DXS7
    Conserved Domains (2) summary
    cd05837
    Location:314 → 417
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    pfam07496
    Location:256 → 302
    zf-CW; CW-type Zinc Finger

  10. NM_001386017.1 → NP_001372946.1  zinc finger CW-type PWWP domain protein 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC005071, AC092849
    UniProtKB/TrEMBL
    B4DXS7
    Conserved Domains (2) summary
    cd05837
    Location:315 → 418
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    pfam07496
    Location:256 → 303
    zf-CW; CW-type Zinc Finger

  11. NM_001386018.1 → NP_001372947.1  zinc finger CW-type PWWP domain protein 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC005071, AC092849
    Conserved Domains (2) summary
    pfam07496
    Location:256 → 303
    zf-CW; CW-type Zinc Finger
    cl02554
    Location:315 → 418
    PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...

  12. NM_001386019.1 → NP_001372948.1  zinc finger CW-type PWWP domain protein 1 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC005071, AC092849
    UniProtKB/TrEMBL
    A0A0S2Z5K5
    Conserved Domains (2) summary
    pfam07496
    Location:188 → 234
    zf-CW; CW-type Zinc Finger
    cl02554
    Location:246 → 349
    PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...

  13. NM_001386020.1 → NP_001372949.1  zinc finger CW-type PWWP domain protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC005071, AC092849
    Consensus CDS
    CCDS59067.1
    Conserved Domains (2) summary
    pfam07496
    Location:256 → 302
    zf-CW; CW-type Zinc Finger
    cl02554
    Location:314 → 417
    PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...

  14. NM_001386021.1 → NP_001372950.1  zinc finger CW-type PWWP domain protein 1 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC005071, AC092849
    Conserved Domains (2) summary
    pfam07496
    Location:55 → 102
    zf-CW; CW-type Zinc Finger
    cl02554
    Location:114 → 217
    PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...

  15. NM_001386022.1 → NP_001372951.1  zinc finger CW-type PWWP domain protein 1 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC005071, AC092849
    Conserved Domains (2) summary
    pfam07496
    Location:256 → 302
    zf-CW; CW-type Zinc Finger
    cl02554
    Location:314 → 385
    PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...

  16. NM_001386023.1 → NP_001372952.1  zinc finger CW-type PWWP domain protein 1 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC005071, AC092849
    UniProtKB/TrEMBL
    A0A0S2Z5E1
    Conserved Domains (2) summary
    pfam07496
    Location:188 → 235
    zf-CW; CW-type Zinc Finger
    cl02554
    Location:247 → 350
    PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...

  17. NM_001388066.1 → NP_001374995.1  zinc finger CW-type PWWP domain protein 1 isoform 15

    Status: VALIDATED

    Source sequence(s)
    AC005071, AC092849

  18. NM_017984.6 → NP_060454.3  zinc finger CW-type PWWP domain protein 1 isoform 1

    See identical proteins and their annotated locations for NP_060454.3

    Status: VALIDATED

    Source sequence(s)
    AC005071, AC092849
    Consensus CDS
    CCDS43623.1
    UniProtKB/Swiss-Prot
    A8MVF5, B4DUQ2, Q8NA98, Q9BUD0, Q9H0M4, Q9NWF7
    UniProtKB/TrEMBL
    B4DXS7
    Related
    ENSP00000381109.2, ENST00000398027.6
    Conserved Domains (2) summary
    cd05837
    Location:313 → 416
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    pfam07496
    Location:256 → 301
    zf-CW; CW-type Zinc Finger

RNA

  1. NR_169828.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC005071, AC092849

  2. NR_169829.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC005071, AC092849

  3. NR_169830.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC005071, AC092849

  4. NR_169831.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC005071, AC092849

  5. NR_169832.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC005071, AC092849

  6. NR_169834.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC005071, AC092849

  7. NR_169835.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC005071, AC092849

  8. NR_169836.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC005071, AC092849

  9. NR_169837.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC005071, AC092849

  10. NR_169838.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC005071, AC092849

  11. NR_169839.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC005071, AC092849

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    100400872..100428703 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047420554.1 → XP_047276510.1  zinc finger CW-type PWWP domain protein 1 isoform X10

  2. XM_006716038.5 → XP_006716101.1  zinc finger CW-type PWWP domain protein 1 isoform X3

    UniProtKB/TrEMBL
    B4DXS7
    Conserved Domains (2) summary
    cd05837
    Location:314 → 417
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    pfam07496
    Location:256 → 302
    zf-CW; CW-type Zinc Finger

  3. XM_017012379.3 → XP_016867868.1  zinc finger CW-type PWWP domain protein 1 isoform X8

    Conserved Domains (2) summary
    pfam07496
    Location:256 → 302
    zf-CW; CW-type Zinc Finger
    cl02554
    Location:314 → 385
    PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...

  4. XM_024446815.2 → XP_024302583.1  zinc finger CW-type PWWP domain protein 1 isoform X6

    UniProtKB/TrEMBL
    B4DXS7
    Conserved Domains (2) summary
    pfam07496
    Location:257 → 302
    zf-CW; CW-type Zinc Finger
    cl02554
    Location:314 → 385
    PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...

  5. XM_005250480.4 → XP_005250537.1  zinc finger CW-type PWWP domain protein 1 isoform X7

    Conserved Domains (2) summary
    pfam07496
    Location:257 → 303
    zf-CW; CW-type Zinc Finger
    cl02554
    Location:315 → 386
    PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...

  6. XM_006716040.5 → XP_006716103.1  zinc finger CW-type PWWP domain protein 1 isoform X5

    UniProtKB/TrEMBL
    B4DXS7
    Conserved Domains (2) summary
    pfam07496
    Location:257 → 303
    zf-CW; CW-type Zinc Finger
    cl02554
    Location:315 → 386
    PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...

  7. XM_006716035.5 → XP_006716098.1  zinc finger CW-type PWWP domain protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006716098.1

    UniProtKB/TrEMBL
    B4DXS7
    Conserved Domains (2) summary
    cd05837
    Location:315 → 418
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    pfam07496
    Location:257 → 303
    zf-CW; CW-type Zinc Finger

  8. XM_047420552.1 → XP_047276508.1  zinc finger CW-type PWWP domain protein 1 isoform X4

    UniProtKB/Swiss-Prot
    A8MVF5, B4DUQ2, Q8NA98, Q9BUD0, Q9H0M4, Q9NWF7

  9. XM_047420553.1 → XP_047276509.1  zinc finger CW-type PWWP domain protein 1 isoform X6

  10. XM_047420551.1 → XP_047276507.1  zinc finger CW-type PWWP domain protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A804HK41

  11. XM_006716036.4 → XP_006716099.1  zinc finger CW-type PWWP domain protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006716099.1

    UniProtKB/TrEMBL
    B4DXS7
    Conserved Domains (2) summary
    cd05837
    Location:315 → 418
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    pfam07496
    Location:257 → 303
    zf-CW; CW-type Zinc Finger

  12. XM_024446817.2 → XP_024302585.1  zinc finger CW-type PWWP domain protein 1 isoform X9

    Conserved Domains (2) summary
    pfam07496
    Location:257 → 303
    zf-CW; CW-type Zinc Finger
    cl02554
    Location:315 → 331
    PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    101640949..101668781 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054358551.1 → XP_054214526.1  zinc finger CW-type PWWP domain protein 1 isoform X10

  2. XM_054358543.1 → XP_054214518.1  zinc finger CW-type PWWP domain protein 1 isoform X3

  3. XM_054358549.1 → XP_054214524.1  zinc finger CW-type PWWP domain protein 1 isoform X8

  4. XM_054358547.1 → XP_054214522.1  zinc finger CW-type PWWP domain protein 1 isoform X6

  5. XM_054358548.1 → XP_054214523.1  zinc finger CW-type PWWP domain protein 1 isoform X7

  6. XM_054358545.1 → XP_054214520.1  zinc finger CW-type PWWP domain protein 1 isoform X5

  7. XM_054358541.1 → XP_054214516.1  zinc finger CW-type PWWP domain protein 1 isoform X1

  8. XM_054358544.1 → XP_054214519.1  zinc finger CW-type PWWP domain protein 1 isoform X4

    UniProtKB/Swiss-Prot
    A8MVF5, B4DUQ2, Q8NA98, Q9BUD0, Q9H0M4, Q9NWF7

  9. XM_054358546.1 → XP_054214521.1  zinc finger CW-type PWWP domain protein 1 isoform X6

  10. XM_054358542.1 → XP_054214517.1  zinc finger CW-type PWWP domain protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A804HK41

  11. XM_054358540.1 → XP_054214515.1  zinc finger CW-type PWWP domain protein 1 isoform X1

  12. XM_054358550.1 → XP_054214525.1  zinc finger CW-type PWWP domain protein 1 isoform X9

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H0M4.2 GenPept UniProtKB/Swiss-Prot:Q9H0M4

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