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ZDHHC4 zinc finger DHHC-type palmitoyltransferase 4 [ Homo sapiens (human) ]

Gene ID: 55146, updated on 2-Nov-2024

Summary

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Official Symbol
ZDHHC4provided by HGNC
Official Full Name
zinc finger DHHC-type palmitoyltransferase 4provided by HGNC
Primary source
HGNC:HGNC:18471
See related
Ensembl:ENSG00000136247 AllianceGenome:HGNC:18471
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF374
Summary
Enables palmitoyltransferase activity. Involved in positive regulation of innate immune response and protein localization to plasma membrane. Located in Golgi apparatus and endoplasmic reticulum. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in thyroid (RPKM 21.7), testis (RPKM 20.1) and 25 other tissues See more
Orthologs
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Genomic context

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See ZDHHC4 in Genome Data Viewer
Location:
7p22.1
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (6577454..6589374)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (6696620..6708547)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (6617085..6629005)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ribosomal protein L31 pseudogene 34 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17946 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17947 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17948 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17949 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17950 Neighboring gene uncharacterized LOC101927325 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25627 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25628 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25629 Neighboring gene Grid2 interacting protein Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17951 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25630 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17952 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:6576361-6577340 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17953 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:6617713-6618328 Neighboring gene uncharacterized LOC124901582 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:6628794-6629632 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:6637314-6637506 Neighboring gene integrator complex subunit 15 Neighboring gene Sharpr-MPRA regulatory region 9377 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:6653371-6654124 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:6654125-6654878 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:6663565-6664065 Neighboring gene zinc finger protein 853

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. GSK3β palmitoylation mediated by ZDHHC4 promotes tumorigenicity of glioblastoma stem cells in temozolomide-resistant glioblastoma through the EZH2-STAT3 axis. Zhao C, et al. Oncogenesis, 2022 May 23. PMID 35606353, Free PMC Article
  2. Effect of C-Terminal S-Palmitoylation on D2 Dopamine Receptor Trafficking and Stability. Ebersole B, et al. PLoS One, 2015. PMID 26535572, Free PMC Article
  3. DHHC4 and DHHC5 Facilitate Fatty Acid Uptake by Palmitoylating and Targeting CD36 to the Plasma Membrane. Wang J, et al. Cell Rep, 2019 Jan 2. PMID 30605677
  4. Endoplasmic reticulum localization of DHHC palmitoyltransferases mediated by lysine-based sorting signals. Gorleku OA, et al. J Biol Chem, 2011 Nov 11. PMID 21926431, Free PMC Article
  5. Proteomics-based identification of proteins interacting with Smad3: SREBP-2 forms a complex with Smad3 and inhibits its transcriptional activity. Grimsby S, et al. FEBS Lett, 2004 Nov 5. PMID 15527767

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ10479

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables palmitoyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-cysteine S-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in positive regulation of innate immune response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein localization to plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
palmitoyltransferase ZDHHC4
Names
DHHC-4
probable palmitoyltransferase ZDHHC4
zinc finger DHHC domain-containing protein 4
zinc finger DHHC-type containing 4
zinc finger protein 374
zinc finger, DHHC domain containing 4
NP_001127859.1
NP_001127860.1
NP_001127861.1
NP_001358221.1
NP_001358222.1
NP_001358223.1
NP_001358224.1
NP_001358225.1
NP_001358226.1
NP_001358227.1
NP_001358228.1
NP_060576.1
XP_005249853.1
XP_047276520.1
XP_047276521.1
XP_047276522.1
XP_047276523.1
XP_054214544.1
XP_054214545.1
XP_054214546.1
XP_054214547.1
XP_054214548.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134387.2 → NP_001127859.1  palmitoyltransferase ZDHHC4 isoform b

    See identical proteins and their annotated locations for NP_001127859.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 5. Variants 1-4 and 6-10 all encode the same isoform (b).
    Source sequence(s)
    AC079742, AK001341, AK223532, BQ185277, BQ925460, CN365375
    Consensus CDS
    CCDS5352.1
    UniProtKB/Swiss-Prot
    A4D2N9, Q53EV7, Q6FIB5, Q9H0R9, Q9NPG8
    Related
    ENSP00000379941.2, ENST00000396713.6
    Conserved Domains (1) summary
    pfam01529
    Location:151 → 292
    DHHC; DHHC palmitoyltransferase

  2. NM_001134388.2 → NP_001127860.1  palmitoyltransferase ZDHHC4 isoform b

    See identical proteins and their annotated locations for NP_001127860.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 5. Variants 1-4 and 6-10 all encode the same isoform (b).
    Source sequence(s)
    AC079742, AK001341, AK223532, BQ185277, BQ925460
    Consensus CDS
    CCDS5352.1
    UniProtKB/Swiss-Prot
    A4D2N9, Q53EV7, Q6FIB5, Q9H0R9, Q9NPG8
    Related
    ENSP00000379935.2, ENST00000396707.6
    Conserved Domains (1) summary
    pfam01529
    Location:151 → 292
    DHHC; DHHC palmitoyltransferase

  3. NM_001134389.2 → NP_001127861.1  palmitoyltransferase ZDHHC4 isoform b

    See identical proteins and their annotated locations for NP_001127861.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 5. Variants 1-4 and 6-10 all encode the same isoform (b).
    Source sequence(s)
    AC079742, AK001341, BQ185277
    Consensus CDS
    CCDS5352.1
    UniProtKB/Swiss-Prot
    A4D2N9, Q53EV7, Q6FIB5, Q9H0R9, Q9NPG8
    Related
    ENSP00000337475.6, ENST00000335965.11
    Conserved Domains (1) summary
    pfam01529
    Location:151 → 292
    DHHC; DHHC palmitoyltransferase

  4. NM_001371292.1 → NP_001358221.1  palmitoyltransferase ZDHHC4 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) encodes the longest isoform (a).
    Source sequence(s)
    AC079742
    Conserved Domains (1) summary
    pfam01529
    Location:151 → 307
    DHHC; DHHC palmitoyltransferase

  5. NM_001371293.1 → NP_001358222.1  palmitoyltransferase ZDHHC4 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 5. Variants 1-4 and 6-10 all encode the same isoform (b).
    Source sequence(s)
    AC079742
    Consensus CDS
    CCDS5352.1
    UniProtKB/Swiss-Prot
    A4D2N9, Q53EV7, Q6FIB5, Q9H0R9, Q9NPG8
    Conserved Domains (1) summary
    pfam01529
    Location:151 → 292
    DHHC; DHHC palmitoyltransferase

  6. NM_001371294.1 → NP_001358223.1  palmitoyltransferase ZDHHC4 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 5. Variants 1-4 and 6-10 all encode the same isoform (b).
    Source sequence(s)
    AC079742
    Consensus CDS
    CCDS5352.1
    UniProtKB/Swiss-Prot
    A4D2N9, Q53EV7, Q6FIB5, Q9H0R9, Q9NPG8
    Conserved Domains (1) summary
    pfam01529
    Location:151 → 292
    DHHC; DHHC palmitoyltransferase

  7. NM_001371295.1 → NP_001358224.1  palmitoyltransferase ZDHHC4 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 5. Variants 1-4 and 6-10 all encode the same isoform (b).
    Source sequence(s)
    AC079742
    Consensus CDS
    CCDS5352.1
    UniProtKB/Swiss-Prot
    A4D2N9, Q53EV7, Q6FIB5, Q9H0R9, Q9NPG8
    Conserved Domains (1) summary
    pfam01529
    Location:151 → 292
    DHHC; DHHC palmitoyltransferase

  8. NM_001371296.1 → NP_001358225.1  palmitoyltransferase ZDHHC4 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 5. Variants 1-4 and 6-10 all encode the same isoform (b).
    Source sequence(s)
    AC079742
    Consensus CDS
    CCDS5352.1
    UniProtKB/Swiss-Prot
    A4D2N9, Q53EV7, Q6FIB5, Q9H0R9, Q9NPG8
    Conserved Domains (1) summary
    pfam01529
    Location:151 → 292
    DHHC; DHHC palmitoyltransferase

  9. NM_001371297.1 → NP_001358226.1  palmitoyltransferase ZDHHC4 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR compared to variant 5. Variants 1-4 and 6-10 all encode the same isoform (b).
    Source sequence(s)
    AC079742
    Consensus CDS
    CCDS5352.1
    UniProtKB/Swiss-Prot
    A4D2N9, Q53EV7, Q6FIB5, Q9H0R9, Q9NPG8
    Related
    ENSP00000379937.1, ENST00000396709.5
    Conserved Domains (1) summary
    pfam01529
    Location:151 → 292
    DHHC; DHHC palmitoyltransferase

  10. NM_001371298.1 → NP_001358227.1  palmitoyltransferase ZDHHC4 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC079742
    Conserved Domains (1) summary
    pfam01529
    Location:131 → 272
    DHHC; DHHC palmitoyltransferase

  11. NM_001371299.1 → NP_001358228.1  palmitoyltransferase ZDHHC4 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC079742
    Conserved Domains (1) summary
    pfam01529
    Location:151 → 232
    DHHC; DHHC palmitoyltransferase

  12. NM_018106.4 → NP_060576.1  palmitoyltransferase ZDHHC4 isoform b

    See identical proteins and their annotated locations for NP_060576.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 5. Variants 1-4 and 6-10 all encode the same isoform (b).
    Source sequence(s)
    AC079742, AK001341, AK223532, BQ185277
    Consensus CDS
    CCDS5352.1
    UniProtKB/Swiss-Prot
    A4D2N9, Q53EV7, Q6FIB5, Q9H0R9, Q9NPG8
    Related
    ENSP00000385027.3, ENST00000405731.7
    Conserved Domains (1) summary
    pfam01529
    Location:151 → 292
    DHHC; DHHC palmitoyltransferase

RNA

  1. NR_163912.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC079742

  2. NR_163913.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC079742

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    6577454..6589374
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047420565.1 → XP_047276521.1  palmitoyltransferase ZDHHC4 isoform X1

    UniProtKB/Swiss-Prot
    A4D2N9, Q53EV7, Q6FIB5, Q9H0R9, Q9NPG8

  2. XM_047420564.1 → XP_047276520.1  palmitoyltransferase ZDHHC4 isoform X1

    UniProtKB/Swiss-Prot
    A4D2N9, Q53EV7, Q6FIB5, Q9H0R9, Q9NPG8

  3. XM_047420566.1 → XP_047276522.1  palmitoyltransferase ZDHHC4 isoform X2

  4. XM_005249796.4 → XP_005249853.1  palmitoyltransferase ZDHHC4 isoform X1

    See identical proteins and their annotated locations for XP_005249853.1

    UniProtKB/Swiss-Prot
    A4D2N9, Q53EV7, Q6FIB5, Q9H0R9, Q9NPG8
    Conserved Domains (1) summary
    pfam01529
    Location:151 → 292
    DHHC; DHHC palmitoyltransferase

  5. XM_047420567.1 → XP_047276523.1  palmitoyltransferase ZDHHC4 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    6696620..6708547
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054358570.1 → XP_054214545.1  palmitoyltransferase ZDHHC4 isoform X1

  2. XM_054358569.1 → XP_054214544.1  palmitoyltransferase ZDHHC4 isoform X1

  3. XM_054358572.1 → XP_054214547.1  palmitoyltransferase ZDHHC4 isoform X2

  4. XM_054358571.1 → XP_054214546.1  palmitoyltransferase ZDHHC4 isoform X1

  5. XM_054358573.1 → XP_054214548.1  palmitoyltransferase ZDHHC4 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NPG8.1 GenPept UniProtKB/Swiss-Prot:Q9NPG8

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