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INTS10 integrator complex subunit 10 [ Homo sapiens (human) ]

Gene ID: 55174, updated on 2-Nov-2024

Summary

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Official Symbol
INTS10provided by HGNC
Official Full Name
integrator complex subunit 10provided by HGNC
Primary source
HGNC:HGNC:25548
See related
Ensembl:ENSG00000104613 MIM:611353; AllianceGenome:HGNC:25548
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
INT10; C8orf35
Summary
INTS10 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in thyroid (RPKM 19.2), prostate (RPKM 12.2) and 25 other tissues See more
Orthologs
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Genomic context

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See INTS10 in Genome Data Viewer
Location:
8p21.3
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (19817416..19852067)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (20082438..20117090)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (19674927..19709578)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene chondroitin sulfate N-acetylgalactosaminyltransferase 1 Neighboring gene uncharacterized LOC124901899 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:19536806-19537406 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27058 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:19589033-19590232 Neighboring gene uncharacterized LOC107986920 Neighboring gene MPRA-validated peak6932 silencer Neighboring gene MPRA-validated peak6933 silencer Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:19670041-19670619 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27059 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18970 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27060 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18969 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27061 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27062 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27063 Neighboring gene uncharacterized LOC124901901 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:19713825-19714324 Neighboring gene NANOG hESC enhancer GRCh37_chr8:19717703-19718429 Neighboring gene uncharacterized LOC105379309

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Genome-wide association study identifies 8p21.3 associated with persistent hepatitis B virus infection among Chinese. Li Y, et al. Nat Commun, 2016 May 31. PMID 27244555, Free PMC Article
  2. Effects of genetic polymorphisms in INTS10 and their interaction with environmental factors on progression from persistent HBV infection to hepatocellular carcinoma. Wu Y, et al. Mol Carcinog, 2021 Sep. PMID 34133796
  3. Somatic Mutation Patterns in Hemizygous Genomic Regions Unveil Purifying Selection during Tumor Evolution. Van den Eynden J, et al. PLoS Genet, 2016 Dec. PMID 28027311, Free PMC Article
  4. Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides. Kooner JS, et al. Nat Genet, 2008 Feb. PMID 18193046
  5. Structure of the catalytic core of the Integrator complex. Pfleiderer MM, et al. Mol Cell, 2021 Mar 18. PMID 33548203, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Effects of genetic polymorphisms in INTS10 and their interaction with environmental factors on progression from persistent HBV infection to hepatocellular carcinoma.
    Title: Effects of genetic polymorphisms in INTS10 and their interaction with environmental factors on progression from persistent HBV infection to hepatocellular carcinoma.
  2. INTS10-INTS13-INTS14 form a functional module of Integrator that binds nucleic acids and the cleavage module.
    Title: INTS10-INTS13-INTS14 form a functional module of Integrator that binds nucleic acids and the cleavage module.
  3. Genome-wide association study in Chinise population highlights a novel antiviral gene INTS10 at 8p21.3 in the clearance of HBV infection. INST10 suppresses HBV replication via IRF3 in liver cells.
    Title: Genome-wide association study identifies 8p21.3 associated with persistent hepatitis B virus infection among Chinese.
  4. Using a 7,781-sample pan-cancer dataset, we first confirmed this in POLR2A are known to confer elevated sensitivity to pharmacological suppression.hese include the POLR2A interacting protein INTS10 as well as genes involved in mRNA splicing, nonsense-mediated mRNA
    Title: Somatic Mutation Patterns in Hemizygous Genomic Regions Unveil Purifying Selection during Tumor Evolution.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides.
EBI GWAS Catalog
Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci.
EBI GWAS Catalog
Identification of germline susceptibility loci in ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ10569

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription elongation by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in snRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in snRNA processing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in snRNA processing NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of integrator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of integrator complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of integrator complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
integrator complex subunit 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001353505.2 → NP_001340434.1  integrator complex subunit 10 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC107964

  2. NM_001353506.2 → NP_001340435.1  integrator complex subunit 10 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC107964

  3. NM_001353507.2 → NP_001340436.1  integrator complex subunit 10 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC107964

  4. NM_001353508.2 → NP_001340437.1  integrator complex subunit 10 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC107964

  5. NM_001353509.2 → NP_001340438.1  integrator complex subunit 10 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC107964

  6. NM_001353510.2 → NP_001340439.1  integrator complex subunit 10 isoform f

    Status: VALIDATED

    Source sequence(s)
    AC107964

  7. NM_001353511.2 → NP_001340440.1  integrator complex subunit 10 isoform h

    Status: VALIDATED

    Source sequence(s)
    AC107964

  8. NM_001353512.2 → NP_001340441.1  integrator complex subunit 10 isoform i

    Status: VALIDATED

    Source sequence(s)
    AC107964

  9. NM_001353513.2 → NP_001340442.1  integrator complex subunit 10 isoform j

    Status: VALIDATED

    Source sequence(s)
    AC107964

  10. NM_001353514.2 → NP_001340443.1  integrator complex subunit 10 isoform k

    Status: VALIDATED

    Source sequence(s)
    AC107964

  11. NM_001353515.2 → NP_001340444.1  integrator complex subunit 10 isoform l

    Status: VALIDATED

    Source sequence(s)
    AC107964

  12. NM_001353516.2 → NP_001340445.1  integrator complex subunit 10 isoform m

    Status: VALIDATED

    Source sequence(s)
    AC107964

  13. NM_001353517.2 → NP_001340446.1  integrator complex subunit 10 isoform n

    Status: VALIDATED

    Description
    Transcript Variant: This variant (14), along with variants 15 and 16, encodes isoform n.
    Source sequence(s)
    AC107964

  14. NM_001353518.2 → NP_001340447.1  integrator complex subunit 10 isoform n

    Status: VALIDATED

    Description
    Transcript Variant: This variant (15), along with variants 14 and 16, encodes isoform n.
    Source sequence(s)
    AC107964

  15. NM_001353519.2 → NP_001340448.1  integrator complex subunit 10 isoform n

    Status: VALIDATED

    Description
    Transcript Variant: This variant (16), along with variants 14 and 15, encodes isoform n.
    Source sequence(s)
    AC107964

  16. NM_001353520.2 → NP_001340449.1  integrator complex subunit 10 isoform o

    Status: VALIDATED

    Source sequence(s)
    AC107964

  17. NM_001353521.2 → NP_001340450.1  integrator complex subunit 10 isoform p

    Status: VALIDATED

    Description
    Transcript Variant: This variant (18), as well as variant 19, encodes isoform p.
    Source sequence(s)
    AC107964

  18. NM_001353522.2 → NP_001340451.1  integrator complex subunit 10 isoform p

    Status: VALIDATED

    Description
    Transcript Variant: This variant (19), as well as variant 18, encodes isoform p.
    Source sequence(s)
    AC107964

  19. NM_018142.4 → NP_060612.2  integrator complex subunit 10 isoform g

    See identical proteins and their annotated locations for NP_060612.2

    Status: VALIDATED

    Source sequence(s)
    AC107964
    Consensus CDS
    CCDS6011.2
    UniProtKB/Swiss-Prot
    Q6IA93, Q7L538, Q7L8C8, Q9H3W8, Q9NVR2
    Related
    ENSP00000381064.3, ENST00000397977.8

RNA

  1. NR_148451.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC107964

  2. NR_148452.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC107964

  3. NR_148453.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC107964

  4. NR_148454.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC107964

  5. NR_148455.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC107964

  6. NR_148456.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC107964

  7. NR_148457.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC107964

  8. NR_148458.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC107964

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    19817416..19852067
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047421928.1 → XP_047277884.1  integrator complex subunit 10 isoform X1

  2. XM_047421929.1 → XP_047277885.1  integrator complex subunit 10 isoform X2

  3. XM_047421930.1 → XP_047277886.1  integrator complex subunit 10 isoform X3

  4. XM_017013607.2 → XP_016869096.1  integrator complex subunit 10 isoform X4

  5. XM_047421931.1 → XP_047277887.1  integrator complex subunit 10 isoform X5

RNA

  1. XR_007060743.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    20082438..20117090
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054360753.1 → XP_054216728.1  integrator complex subunit 10 isoform X1

  2. XM_054360754.1 → XP_054216729.1  integrator complex subunit 10 isoform X2

  3. XM_054360755.1 → XP_054216730.1  integrator complex subunit 10 isoform X3

  4. XM_054360756.1 → XP_054216731.1  integrator complex subunit 10 isoform X4

  5. XM_054360757.1 → XP_054216732.1  integrator complex subunit 10 isoform X5

RNA

  1. XR_008487861.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NVR2.2 GenPept UniProtKB/Swiss-Prot:Q9NVR2

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