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OLAH oleoyl-ACP hydrolase [ Homo sapiens (human) ]

Gene ID: 55301, updated on 11-Apr-2024

Summary

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Official Symbol
OLAHprovided by HGNC
Official Full Name
oleoyl-ACP hydrolaseprovided by HGNC
Primary source
HGNC:HGNC:25625
See related
Ensembl:ENSG00000152463 AllianceGenome:HGNC:25625
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TE2; SAST; AURA1; THEDC1
Summary
Enables dodecanoyl-[acyl-carrier-protein] hydrolase activity; myristoyl-[acyl-carrier-protein] hydrolase activity; and palmitoyl-[acyl-carrier-protein] hydrolase activity. Involved in medium-chain fatty acid biosynthetic process. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis (RPKM 8.6) and placenta (RPKM 2.3) See more
Orthologs
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Genomic context

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See OLAH in Genome Data Viewer
Location:
10p13
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (15032195..15073853)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (15046189..15087828)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (15085942..15115852)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 7 subfamily E member 26 pseudogene Neighboring gene ACBD7-DCLRE1CP1 readthrough Neighboring gene olfactory receptor family 7 subfamily E member 115 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3088 Neighboring gene DNA cross-link repair 1C pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3089 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:15089045-15089853 Neighboring gene MPRA-validated peak869 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:15125454-15125977 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:15125978-15126500 Neighboring gene acyl-CoA binding domain containing 7 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2167 Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 45

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Crystal Structure and Substrate Specificity of Human Thioesterase 2: INSIGHTS INTO THE MOLECULAR BASIS FOR THE MODULATION OF FATTY ACID SYNTHASE. Ritchie MK, et al. J Biol Chem, 2016 Feb 12. PMID 26663084, Free PMC Article
  2. Isolation and expression profiling of genes upregulated in bone marrow-derived mononuclear cells of rheumatoid arthritis patients. Nakamura N, et al. DNA Res, 2006 Aug 31. PMID 17082220
  3. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. Grupe A, et al. Am J Hum Genet, 2006 Jan. PMID 16385451, Free PMC Article
  4. E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins. Khanna R, et al. FEBS J, 2018 Jun. PMID 29676528
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. Lamesch P, et al. Genomics, 2007 Mar. PMID 17207965, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Observational study of gene-disease association. (HuGE Navigator)
    Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ11106, MGC51852

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables fatty acyl-[ACP] hydrolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in lipid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in medium-chain fatty acid biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
S-acyl fatty acid synthase thioesterase, medium chain
Names
augmented in rheumatoid arthritis 1
oleoyl-acyl-carrier-protein hydrolase
thioesterase 2
thioesterase II
thioesterase domain containing 1
thioesterase domain-containing protein 1
NP_001034791.1
NP_060794.1
XP_016871865.1
XP_024303828.1
XP_047281379.1
XP_054222181.1
XP_054222182.1
XP_054222183.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039702.3 → NP_001034791.1  S-acyl fatty acid synthase thioesterase, medium chain isoform 2

    See identical proteins and their annotated locations for NP_001034791.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AK001968, AL590365, BC050372, BG281536
    Consensus CDS
    CCDS31152.1
    UniProtKB/Swiss-Prot
    Q5VUB6, Q9NUW1, Q9NV23
    Related
    ENSP00000367473.4, ENST00000378228.8
    Conserved Domains (1) summary
    COG3208
    Location:22 → 242
    GrsT; Surfactin synthase thioesterase subunit [Secondary metabolites biosynthesis, transport and catabolism]

  2. NM_018324.3 → NP_060794.1  S-acyl fatty acid synthase thioesterase, medium chain isoform 1

    See identical proteins and their annotated locations for NP_060794.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK001968, AL590365, BG281536, BI830605
    Consensus CDS
    CCDS7106.1
    UniProtKB/Swiss-Prot
    Q9NV23
    Related
    ENSP00000367462.3, ENST00000378217.3
    Conserved Domains (2) summary
    COG3208
    Location:22 → 295
    GrsT; Surfactin synthase thioesterase subunit [Secondary metabolites biosynthesis, transport and catabolism]
    pfam12697
    Location:106 → 297
    Abhydrolase_6; Alpha/beta hydrolase family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    15032195..15073853
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047425423.1 → XP_047281379.1  S-acyl fatty acid synthase thioesterase, medium chain isoform X1

  2. XM_024448060.2 → XP_024303828.1  S-acyl fatty acid synthase thioesterase, medium chain isoform X2

    UniProtKB/Swiss-Prot
    Q5VUB6, Q9NUW1, Q9NV23
    Conserved Domains (1) summary
    COG3208
    Location:22 → 242
    GrsT; Surfactin synthase thioesterase subunit [Secondary metabolites biosynthesis, transport and catabolism]

  3. XM_017016376.3 → XP_016871865.1  S-acyl fatty acid synthase thioesterase, medium chain isoform X1

    UniProtKB/Swiss-Prot
    Q9NV23
    Conserved Domains (2) summary
    COG3208
    Location:22 → 295
    GrsT; Surfactin synthase thioesterase subunit [Secondary metabolites biosynthesis, transport and catabolism]
    pfam12697
    Location:106 → 297
    Abhydrolase_6; Alpha/beta hydrolase family

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    15046189..15087828
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054366207.1 → XP_054222182.1  S-acyl fatty acid synthase thioesterase, medium chain isoform X1

  2. XM_054366208.1 → XP_054222183.1  S-acyl fatty acid synthase thioesterase, medium chain isoform X2

    UniProtKB/Swiss-Prot
    Q5VUB6, Q9NUW1, Q9NV23

  3. XM_054366206.1 → XP_054222181.1  S-acyl fatty acid synthase thioesterase, medium chain isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NV23.1 GenPept UniProtKB/Swiss-Prot:Q9NV23

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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