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CPPED1 calcineurin like phosphoesterase domain containing 1 [ Homo sapiens (human) ]

Gene ID: 55313, updated on 2-Nov-2024

Summary

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Official Symbol
CPPED1provided by HGNC
Official Full Name
calcineurin like phosphoesterase domain containing 1provided by HGNC
Primary source
HGNC:HGNC:25632
See related
Ensembl:ENSG00000103381 MIM:615603; AllianceGenome:HGNC:25632
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CSTP1
Summary
Predicted to enable metal ion binding activity and myosin phosphatase activity. Located in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in spleen (RPKM 8.6), kidney (RPKM 8.5) and 24 other tissues See more
Orthologs
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Genomic context

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See CPPED1 in Genome Data Viewer
Location:
16p13.12
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (12659799..12803887, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (12696825..12840919, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (12753656..12897744, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene sorting nexin 29 Neighboring gene uncharacterized LOC105371085 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7219 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10472 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10473 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10474 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10475 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10476 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:12685995-12686514 Neighboring gene CRISPRi-validated cis-regulatory element chr16.1337 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr16:12707003-12708202 Neighboring gene Sharpr-MPRA regulatory region 11276 Neighboring gene uncharacterized LOC105371088 Neighboring gene Sharpr-MPRA regulatory region 10358 Neighboring gene uncharacterized LOC105371090 Neighboring gene microRNA 4718 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10479 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10480 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7220 Neighboring gene MPRA-validated peak2502 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7221 Neighboring gene small nucleolar RNA SNORA27 Neighboring gene ribosomal protein L35a pseudogene 34

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Identification of a non-purple tartrate-resistant acid phosphatase: an evolutionary link to Ser/Thr protein phosphatases? Hadler KS, et al. BMC Res Notes, 2008 Sep 4. PMID 18771593, Free PMC Article
  2. Expression of CPPED1 in human trophoblasts is associated with timing of term birth. Haapalainen AM, et al. J Cell Mol Med, 2018 Feb. PMID 29193784, Free PMC Article
  3. Downregulation of CPPED1 expression improves glucose metabolism in vitro in adipocytes. Vaittinen M, et al. Diabetes, 2013 Nov. PMID 23939394, Free PMC Article
  4. The UAS thioredoxin-like domain of UBXN7 regulates E3 ubiquitin ligase activity of RNF111/Arkadia. Amhaz S, et al. BMC Biol, 2023 Apr 7. PMID 37024974, Free PMC Article
  5. Cellular substrates and pro-apoptotic function of the human HtrA4 protease. Wenta T, et al. J Proteomics, 2019 Oct 30. PMID 31470122

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. functions regulated by CPPED1 in trophoblasts at choriodecidual interphase have a role in the induction of term labour, but it may be independent of AKT1.
    Title: Expression of CPPED1 in human trophoblasts is associated with timing of term birth.
  2. CPPED1 is involved in glucose uptake in adipocytes
    Title: Downregulation of CPPED1 expression improves glucose metabolism in vitro in adipocytes.
  3. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ11151

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in azurophil granule lumen TAS
Traceable Author Statement
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in extracellular region TAS
Traceable Author Statement
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
serine/threonine-protein phosphatase CPPED1
Names
calcineurin-like phosphoesterase domain-containing protein 1
complete S-transactivated protein 1
NP_001092925.1
NP_060810.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099455.2 → NP_001092925.1  serine/threonine-protein phosphatase CPPED1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform b), compared to isoform a.
    Source sequence(s)
    AC010333, AC092324
    Consensus CDS
    CCDS42119.1
    UniProtKB/Swiss-Prot
    Q9BRF8
    Related
    ENSP00000411127.2, ENST00000433677.6
    Conserved Domains (1) summary
    cl13995
    Location:29 → 153
    MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain

  2. NM_018340.3 → NP_060810.2  serine/threonine-protein phosphatase CPPED1 isoform a

    See identical proteins and their annotated locations for NP_060810.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC010333, AC092324
    Consensus CDS
    CCDS42120.1
    UniProtKB/Swiss-Prot
    B4DQ68, Q6MZY9, Q9BRF8, Q9H9M9, Q9NUT6
    Related
    ENSP00000371193.4, ENST00000381774.9
    Conserved Domains (2) summary
    COG1409
    Location:67 → 269
    CpdA; 3',5'-cyclic AMP phosphodiesterase CpdA [Signal transduction mechanisms]
    cd07395
    Location:29 → 295
    MPP_CSTP1; Homo sapiens CSTP1 and related proteins, metallophosphatase domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    12659799..12803887 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    12696825..12840919 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BRF8.3 GenPept UniProtKB/Swiss-Prot:Q9BRF8

Gene LinkOut

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