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2610042L04Rik RIKEN cDNA 2610042L04 gene [ Mus musculus (house mouse) ]

Gene ID: 554327, updated on 2-Nov-2024

Summary

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Official Symbol
2610042L04Rikprovided by MGI
Official Full Name
RIKEN cDNA 2610042L04 geneprovided by MGI
Primary source
MGI:MGI:1914305
See related
Ensembl:ENSMUSG00000079388 AllianceGenome:MGI:1914305
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tksn; takusan
Summary
Acts upstream of or within several processes, including negative regulation of protein phosphorylation; regulation of synaptic activity; and synapse assembly. Is expressed in several structures, including ganglia; hypothalamus; sensory organ; smooth muscle tissue; and submandibular gland primordium. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in CNS E18 (RPKM 4.3), whole brain E14.5 (RPKM 2.9) and 18 other tissues See more
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Genomic context

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See 2610042L04Rik in Genome Data Viewer
Location:
14 A2; 14 2.36 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (18115086..18135894, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (4333878..4354687)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene 3164 Neighboring gene predicted gene 3159 Neighboring gene predicted gene 3138 Neighboring gene predicted gene 2974

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Synaptic protein α1-takusan mitigates amyloid-β-induced synaptic loss via interaction with tau and postsynaptic density-95 at postsynaptic sites. Nakanishi N, et al. J Neurosci, 2013 Aug 28. PMID 23986251, Free PMC Article
  2. Genome-wide analysis of gene transcription in the hypothalamus. Bischof JM, et al. Physiol Genomics, 2005 Jul 14. PMID 15870395
  3. Discrete gene sets depend on POU domain transcription factor Brn3b/Brn-3.2/POU4f2 for their expression in the mouse embryonic retina. Mu X, et al. Development, 2004 Mar. PMID 14973295
  4. Takusan: a large gene family that regulates synaptic activity. Tu S, et al. Neuron, 2007 Jul 5. PMID 17610818, Free PMC Article
  5. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of mitochondrion organization IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of synaptic activity IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of synaptic activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within synapse assembly IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within synapse assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
uncharacterized protein LOC554327
Names
alpha42-takusan
alpha46-takusan

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001309398.1 → NP_001296327.1  uncharacterized protein LOC554327

    See identical proteins and their annotated locations for NP_001296327.1

    Status: VALIDATED

    Source sequence(s)
    AC188088, AK011748
    Consensus CDS
    CCDS84074.1
    UniProtKB/TrEMBL
    A6NAV3, Q9D073
    Related
    ENSMUSP00000132127.2, ENSMUST00000165466.8
    Conserved Domains (1) summary
    pfam04822
    Location:1 → 73
    Takusan

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    18115086..18135894 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247891.2 → XP_030103751.1  uncharacterized protein LOC554327 isoform X10

    UniProtKB/TrEMBL
    A6NAV3, Q9D073
    Conserved Domains (1) summary
    pfam04822
    Location:1 → 73
    Takusan

  2. XM_017316095.3 → XP_017171584.1  uncharacterized protein LOC554327 isoform X10

    UniProtKB/TrEMBL
    A6NAV3, Q9D073
    Conserved Domains (1) summary
    pfam04822
    Location:1 → 73
    Takusan

  3. XM_030247892.2 → XP_030103752.1  uncharacterized protein LOC554327 isoform X11

  4. XM_017316091.3 → XP_017171580.1  uncharacterized protein LOC554327 isoform X6

  5. XM_017316092.3 → XP_017171581.1  uncharacterized protein LOC554327 isoform X7

  6. XM_017316090.2 → XP_017171579.1  uncharacterized protein LOC554327 isoform X5

  7. XM_017316094.2 → XP_017171583.1  uncharacterized protein LOC554327 isoform X9

  8. XM_017316093.2 → XP_017171582.1  uncharacterized protein LOC554327 isoform X8

  9. XM_036158764.1 → XP_036014657.1  uncharacterized protein LOC554327 isoform X3

  10. XM_017316089.2 → XP_017171578.1  uncharacterized protein LOC554327 isoform X4

  11. XM_017316088.3 → XP_017171577.1  uncharacterized protein LOC554327 isoform X2

  12. XM_017316087.3 → XP_017171576.1  uncharacterized protein LOC554327 isoform X1

RNA

  1. XR_874067.4 RNA Sequence

  2. XR_004938417.1 RNA Sequence

  3. XR_874065.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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