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STRADB STE20 related adaptor beta [ Homo sapiens (human) ]

Gene ID: 55437, updated on 5-Mar-2024

Summary

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Official Symbol
STRADBprovided by HGNC
Official Full Name
STE20 related adaptor betaprovided by HGNC
Primary source
HGNC:HGNC:13205
See related
Ensembl:ENSG00000082146 MIM:607333; AllianceGenome:HGNC:13205
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAPK; ILPIP; ILPIPA; ALS2CR2; CALS-21; PRO1038
Summary
This gene encodes a protein that belongs to the serine/threonine protein kinase STE20 subfamily. One of the active site residues in the protein kinase domain of this protein is altered, and it is thus a pseudokinase. This protein is a component of a complex involved in the activation of serine/threonine kinase 11, a master kinase that regulates cell polarity and energy-generating metabolism. This complex regulates the relocation of this kinase from the nucleus to the cytoplasm, and it is essential for G1 cell cycle arrest mediated by this kinase. The protein encoded by this gene can also interact with the X chromosome-linked inhibitor of apoptosis protein, and this interaction enhances the anti-apoptotic activity of this protein via the JNK1 signal transduction pathway. Two pseudogenes, located on chromosomes 1 and 7, have been found for this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]
Expression
Ubiquitous expression in bone marrow (RPKM 24.2), kidney (RPKM 22.5) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
2q33.1
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (201451740..201480846)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (201932523..201961624)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (202316463..202345569)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 2:202153225 Neighboring gene flagellum associated containing coiled-coil domains 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:202184683-202185184 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:202185185-202185684 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16990 Neighboring gene trafficking kinesin protein 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:202289002-202289502 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:202289503-202290003 Neighboring gene SCYL2 pseudogene 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:202315536-202316390 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12232 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:202329405-202329904 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:202348230-202348988 Neighboring gene uncharacterized LOC124906113 Neighboring gene C2 calcium dependent domain containing 6 Neighboring gene MPRA-validated peak4010 silencer Neighboring gene MT-CO1 pseudogene 16

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. LKB1-dependent signaling pathways. Alessi DR, et al. Annu Rev Biochem, 2006. PMID 16756488
  2. Emerging roles of pseudokinases. Boudeau J, et al. Trends Cell Biol, 2006 Sep. PMID 16879967
  3. Identification and characterization of a novel Ste20/germinal center kinase-related kinase, polyploidy-associated protein kinase. Nishigaki K, et al. J Biol Chem, 2003 Apr 11. PMID 12574163
  4. MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm. Boudeau J, et al. EMBO J, 2003 Oct 1. PMID 14517248, Free PMC Article
  5. ILPIP, a novel anti-apoptotic protein that enhances XIAP-mediated activation of JNK1 and protection against apoptosis. Sanna MG, et al. J Biol Chem, 2002 Aug 23. PMID 12048196

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. a novel XIAP-interacting protein that acts as a co-factor enhancing XIAP-mediated activation of JNK1 and the caspase-independent protection of XIAP against apoptosis
    Title: ILPIP, a novel anti-apoptotic protein that enhances XIAP-mediated activation of JNK1 and protection against apoptosis.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC102916

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
NOT enables protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in JNK cascade IEA
Inferred from Electronic Annotation
more info
  
involved_in activation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in activation of protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in cell morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IEA
Inferred from Electronic Annotation
more info
  
involved_in protein export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein export from nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
NOT involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in aggresome IDA
Inferred from Direct Assay
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of serine/threonine protein kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of serine/threonine protein kinase complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
STE20-related kinase adapter protein beta
Names
ILP-interacting protein ILPIPA
STE20-related kinase adaptor beta
STRAD beta
amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 2
amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein
pseudokinase ALS2CR2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029572.2 RefSeqGene

    Range
    5002..34108
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001206864.2 → NP_001193793.1  STE20-related kinase adapter protein beta isoform 2

    See identical proteins and their annotated locations for NP_001193793.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate splice site in the 3' coding region, resulting in a longer transcript and a reading frame-shift, compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC007282
    Consensus CDS
    CCDS56161.1
    UniProtKB/TrEMBL
    A8K342
    Related
    ENSP00000376080.2, ENST00000392249.6
    Conserved Domains (2) summary
    smart00220
    Location:58 → 369
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08226
    Location:59 → 371
    PK_STRAD_beta; Pseudokinase domain of STE20-related kinase adapter protein beta

  2. NM_018571.6 → NP_061041.2  STE20-related kinase adapter protein beta isoform 1

    See identical proteins and their annotated locations for NP_061041.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC007282
    Consensus CDS
    CCDS2348.1
    UniProtKB/Swiss-Prot
    Q5BKY7, Q9C0K7, Q9P1L0
    UniProtKB/TrEMBL
    A8K342
    Related
    ENSP00000194530.3, ENST00000194530.8
    Conserved Domains (1) summary
    cd08226
    Location:59 → 386
    PK_STRAD_beta; Pseudokinase domain of STE20-related kinase adapter protein beta

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    201451740..201480846
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005246669.3 → XP_005246726.1  STE20-related kinase adapter protein beta isoform X1

    See identical proteins and their annotated locations for XP_005246726.1

    Conserved Domains (2) summary
    smart00220
    Location:58 → 272
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:59 → 276
    PKc_like; Protein Kinases, catalytic domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    201932523..201961624
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054342834.1 → XP_054198809.1  STE20-related kinase adapter protein beta isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9C0K7.1 GenPept UniProtKB/Swiss-Prot:Q9C0K7

Gene LinkOut

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