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grm1a - glutamate receptor, metabotropic 1a

Predicted to enable G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential; adenylate cyclase inhibiting G protein-coupled glutamate receptor activity; and neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration. Predicted to be involved in G protein-coupled glutamate receptor signaling pathway and regulation of glutamatergic synaptic transmission. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in postsynaptic density membrane. Is expressed in brain and retinal neural layer. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 13 and spinocerebellar ataxia 44. Orthologous to human GRM1 (glutamate metabotropic receptor 1). [provided by Alliance of Genome Resources, Oct 2024]

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Species Gene Architecture aa