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CDC42BPG CDC42 binding protein kinase gamma [ Homo sapiens (human) ]

Gene ID: 55561, updated on 5-Mar-2024

Summary

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Official Symbol
CDC42BPGprovided by HGNC
Official Full Name
CDC42 binding protein kinase gammaprovided by HGNC
Primary source
HGNC:HGNC:29829
See related
Ensembl:ENSG00000171219 MIM:613991; AllianceGenome:HGNC:29829
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DMPK2; MRCKG; HSMDPKIN; KAPPA-200; MRCKgamma
Summary
Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in protein phosphorylation. Located in cell leading edge; centriolar satellite; and cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in skin (RPKM 11.8), stomach (RPKM 5.1) and 20 other tissues See more
Orthologs
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Genomic context

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Location:
11q13.1
Exon count:
40
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (64823052..64844653, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (64816347..64837971, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (64590524..64612125, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:64557481-64557982 Neighboring gene mitogen-activated protein kinase kinase kinase kinase 2 Neighboring gene Sharpr-MPRA regulatory region 11124 Neighboring gene MPRA-validated peak1298 silencer Neighboring gene Sharpr-MPRA regulatory region 2965 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4916 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4917 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3490 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3491 Neighboring gene menin 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4918 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:64594480-64594980 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:64609163-64609975 Neighboring gene Sharpr-MPRA regulatory region 8286 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:64610788-64611600 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3492 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3493 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3494 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3495 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4919 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4920 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4921 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:64620804-64621802 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:64622049-64623248 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4923 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4924 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4925 Neighboring gene EH domain containing 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:64630869-64631680 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4926 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4927 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4928 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:64641208-64641398 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:64644230-64645006 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3498 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3499 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4930 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4931 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4932 Neighboring gene microRNA 10392 Neighboring gene ribosomal protein S16 pseudogene 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Identification of CDC42BPG as a novel susceptibility locus for hyperuricemia in a Japanese population. Yasukochi Y, et al. Mol Genet Genomics, 2018 Apr. PMID 29124443, Free PMC Article
  2. The germinal center kinase gene and a novel CDC25-like gene are located in the vicinity of the PYGM gene on 11q13. Kedra D, et al. Hum Genet, 1997 Oct. PMID 9341881
  3. MRCKα is activated by caspase cleavage to assemble an apical actin ring for epithelial cell extrusion. Gagliardi PA, et al. J Cell Biol, 2018 Jan 2. PMID 29162624, Free PMC Article
  4. Expression of the human myotonic dystrophy kinase-related Cdc42-binding kinase gamma is regulated by promoter DNA methylation and Sp1 binding. Ng Y, et al. J Biol Chem, 2004 Aug 13. PMID 15194684
  5. Genome-wide association study for serum urate concentrations and gout among African Americans identifies genomic risk loci and a novel URAT1 loss-of-function allele. Tin A, et al. Hum Mol Genet, 2011 Oct 15. PMID 21768215, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Findings indicate that CDC42BPG may be a susceptibility locus for hyperuricemia.
    Title: Identification of CDC42BPG as a novel susceptibility locus for hyperuricemia in a Japanese population.
  2. CDC42BPG expression is regulated by promoter methylation and Sp1 binding.
    Title: Expression of the human myotonic dystrophy kinase-related Cdc42-binding kinase gamma is regulated by promoter DNA methylation and Sp1 binding.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study for serum urate concentrations and gout among African Americans identifies genomic risk loci and a novel URAT1 loss-of-function allele.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in actomyosin structure organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-threonine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cell leading edge IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centriolar satellite IDA
Inferred from Direct Assay
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase MRCK gamma
Names
CDC42 binding protein kinase gamma (DMPK-like)
DMPK-like gamma
MRCK gamma
myotonic dystrophy kinase-related CDC42-binding kinase gamma
myotonic dystrophy protein kinase like protein
myotonic dystrophy protein kinase-like alpha
myotonic dystrophy protein kinase-like gamma
NP_059995.2
XP_011543457.1
XP_011543458.1
XP_011543459.1
XP_011543460.1
XP_011543461.1
XP_011543462.1
XP_011543463.1
XP_016873485.1
XP_016873486.1
XP_016873487.1
XP_047283204.1
XP_047283205.1
XP_047283206.1
XP_047283207.1
XP_054225299.1
XP_054225300.1
XP_054225301.1
XP_054225302.1
XP_054225303.1
XP_054225304.1
XP_054225305.1
XP_054225306.1
XP_054225307.1
XP_054225308.1
XP_054225309.1
XP_054225310.1
XP_054225311.1
XP_054225312.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017525.3 → NP_059995.2  serine/threonine-protein kinase MRCK gamma

    See identical proteins and their annotated locations for NP_059995.2

    Status: VALIDATED

    Source sequence(s)
    AP001187, AY648038, BI793270
    Consensus CDS
    CCDS31601.1
    UniProtKB/Swiss-Prot
    O00565, Q6DT37
    Related
    ENSP00000345133.5, ENST00000342711.6
    Conserved Domains (7) summary
    pfam08826
    Location:744 → 801
    DMPK_coil; DMPK coiled coil domain like
    smart00220
    Location:71 → 337
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd01243
    Location:938 → 1070
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05597
    Location:69 → 399
    STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
    pfam00130
    Location:879 → 921
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:1097 → 1360
    CNH; CNH domain
    pfam13868
    Location:410 → 802
    TPH; Trichohyalin-plectin-homology domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    64823052..64844653 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047427250.1 → XP_047283206.1  serine/threonine-protein kinase MRCK gamma isoform X7

  2. XM_047427248.1 → XP_047283204.1  serine/threonine-protein kinase MRCK gamma isoform X4

  3. XM_011545156.4 → XP_011543458.1  serine/threonine-protein kinase MRCK gamma isoform X3

    Conserved Domains (7) summary
    pfam08826
    Location:737 → 794
    DMPK_coil; DMPK coiled coil domain like
    smart00220
    Location:71 → 337
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd01243
    Location:949 → 1081
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05597
    Location:69 → 399
    STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
    pfam00130
    Location:890 → 932
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:1108 → 1371
    CNH; CNH domain
    pfam15558
    Location:422 → 794
    DUF4659; Domain of unknown function (DUF4659)

  4. XM_017017996.3 → XP_016873485.1  serine/threonine-protein kinase MRCK gamma isoform X2

  5. XM_047427249.1 → XP_047283205.1  serine/threonine-protein kinase MRCK gamma isoform X6

  6. XM_011545158.4 → XP_011543460.1  serine/threonine-protein kinase MRCK gamma isoform X8

    Conserved Domains (7) summary
    pfam08826
    Location:744 → 801
    DMPK_coil; DMPK coiled coil domain like
    smart00220
    Location:71 → 337
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd01243
    Location:956 → 1088
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05597
    Location:69 → 399
    STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
    pfam00130
    Location:897 → 939
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam13868
    Location:410 → 802
    TPH; Trichohyalin-plectin-homology domain
    cl02434
    Location:1115 → 1340
    CNH; CNH domain

  7. XM_011545157.4 → XP_011543459.1  serine/threonine-protein kinase MRCK gamma isoform X5

    Conserved Domains (7) summary
    pfam08826
    Location:744 → 801
    DMPK_coil; DMPK coiled coil domain like
    smart00220
    Location:71 → 337
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd01243
    Location:956 → 1088
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05597
    Location:69 → 399
    STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
    pfam00130
    Location:897 → 939
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam13868
    Location:410 → 802
    TPH; Trichohyalin-plectin-homology domain
    cl02434
    Location:1115 → 1340
    CNH; CNH domain

  8. XM_011545155.4 → XP_011543457.1  serine/threonine-protein kinase MRCK gamma isoform X1

    See identical proteins and their annotated locations for XP_011543457.1

    Conserved Domains (7) summary
    pfam08826
    Location:744 → 801
    DMPK_coil; DMPK coiled coil domain like
    smart00220
    Location:71 → 337
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd01243
    Location:956 → 1088
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05597
    Location:69 → 399
    STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
    pfam00130
    Location:897 → 939
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:1115 → 1378
    CNH; CNH domain
    pfam13868
    Location:410 → 802
    TPH; Trichohyalin-plectin-homology domain

  9. XM_011545160.4 → XP_011543462.1  serine/threonine-protein kinase MRCK gamma isoform X10

    Conserved Domains (8) summary
    pfam08826
    Location:646 → 703
    DMPK_coil; DMPK coiled coil domain like
    smart00220
    Location:1 → 239
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd01243
    Location:858 → 990
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05597
    Location:1 → 301
    STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
    pfam00130
    Location:799 → 841
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00169
    Location:870 → 986
    PH; PH domain
    pfam00780
    Location:1017 → 1280
    CNH; CNH domain
    pfam13868
    Location:312 → 704
    TPH; Trichohyalin-plectin-homology domain

  10. XM_011545159.4 → XP_011543461.1  serine/threonine-protein kinase MRCK gamma isoform X9

    Conserved Domains (7) summary
    pfam08826
    Location:744 → 801
    DMPK_coil; DMPK coiled coil domain like
    smart00220
    Location:71 → 337
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd01243
    Location:956 → 1088
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05597
    Location:69 → 399
    STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
    pfam00130
    Location:897 → 939
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:1115 → 1378
    CNH; CNH domain
    pfam13868
    Location:410 → 802
    TPH; Trichohyalin-plectin-homology domain

  11. XM_017017998.3 → XP_016873487.1  serine/threonine-protein kinase MRCK gamma isoform X14

  12. XM_047427251.1 → XP_047283207.1  serine/threonine-protein kinase MRCK gamma isoform X13

  13. XM_017017997.3 → XP_016873486.1  serine/threonine-protein kinase MRCK gamma isoform X11

  14. XM_011545161.4 → XP_011543463.1  serine/threonine-protein kinase MRCK gamma isoform X12

    Conserved Domains (5) summary
    pfam08826
    Location:744 → 801
    DMPK_coil; DMPK coiled coil domain like
    smart00220
    Location:71 → 337
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd01243
    Location:956 → 1088
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05597
    Location:69 → 399
    STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
    pfam00130
    Location:897 → 939
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

RNA

  1. XR_949988.4 RNA Sequence

  2. XR_949989.4 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    64816347..64837971 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054369330.1 → XP_054225305.1  serine/threonine-protein kinase MRCK gamma isoform X7

  2. XM_054369327.1 → XP_054225302.1  serine/threonine-protein kinase MRCK gamma isoform X4

  3. XM_054369326.1 → XP_054225301.1  serine/threonine-protein kinase MRCK gamma isoform X3

  4. XM_054369325.1 → XP_054225300.1  serine/threonine-protein kinase MRCK gamma isoform X2

  5. XM_054369329.1 → XP_054225304.1  serine/threonine-protein kinase MRCK gamma isoform X6

  6. XM_054369331.1 → XP_054225306.1  serine/threonine-protein kinase MRCK gamma isoform X8

  7. XM_054369328.1 → XP_054225303.1  serine/threonine-protein kinase MRCK gamma isoform X5

  8. XM_054369324.1 → XP_054225299.1  serine/threonine-protein kinase MRCK gamma isoform X1

  9. XM_054369333.1 → XP_054225308.1  serine/threonine-protein kinase MRCK gamma isoform X10

  10. XM_054369332.1 → XP_054225307.1  serine/threonine-protein kinase MRCK gamma isoform X9

  11. XM_054369337.1 → XP_054225312.1  serine/threonine-protein kinase MRCK gamma isoform X14

  12. XM_054369336.1 → XP_054225311.1  serine/threonine-protein kinase MRCK gamma isoform X13

  13. XM_054369334.1 → XP_054225309.1  serine/threonine-protein kinase MRCK gamma isoform X11

  14. XM_054369335.1 → XP_054225310.1  serine/threonine-protein kinase MRCK gamma isoform X12

RNA

  1. XR_008488418.1 RNA Sequence

  2. XR_008488419.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6DT37.2 GenPept UniProtKB/Swiss-Prot:Q6DT37

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