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ZNF821 zinc finger protein 821 [ Homo sapiens (human) ]

Gene ID: 55565, updated on 2-Nov-2024

Summary

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Official Symbol
ZNF821provided by HGNC
Official Full Name
zinc finger protein 821provided by HGNC
Primary source
HGNC:HGNC:28043
See related
Ensembl:ENSG00000102984 AllianceGenome:HGNC:28043
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a protein with two C2H2 zinc finger motifs and a score-and-three (23)-amino acid peptide repeat (STPR) domain. The STPR domain of the encoded protein binds to double stranded DNA and may also contain a nuclear localization signal, suggesting that this protein interacts with chromosomal DNA. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
Expression
Broad expression in testis (RPKM 7.7), brain (RPKM 2.9) and 23 other tissues See more
Orthologs
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Genomic context

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See ZNF821 in Genome Data Viewer
Location:
16q22.2
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (71859680..71895256, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (77676829..77701807, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (71893583..71918559, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene tripartite motif containing 13 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11080 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:71878951-71879723 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:71879724-71880495 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:71884603-71885382 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11083 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11084 Neighboring gene ataxin 1 like Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11085 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7686 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7687 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:71918951-71919451 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:71929209-71929774 Neighboring gene IST1 factor associated with ESCRT-III Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11088 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:71971508-71972085 Neighboring gene polycystin 1 like 3, transient receptor potential channel interacting Neighboring gene ribosomal protein L39 pseudogene 31 Neighboring gene ATP synthase F1 subunit alpha pseudogene 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. STPR, a 23-amino acid tandem repeat domain, found in the human function-unknown protein ZNF821. Nonaka Y, et al. Biochemistry, 2010 Sep 28. PMID 20795678
  2. Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation. Fan X, et al. Stem Cell Res Ther, 2021 Feb 4. PMID 33541421, Free PMC Article
  3. Systematic identification of molecular links between core and candidate genes in breast cancer. Arroyo R, et al. J Mol Biol, 2015 Mar 27. PMID 25640309
  4. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Yin Y, et al. Science, 2017 May 5. PMID 28473536, Free PMC Article
  5. Protein interactome reveals converging molecular pathways among autism disorders. Sakai Y, et al. Sci Transl Med, 2011 Jun 8. PMID 21653829, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ16350

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 821

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001201552.2 → NP_001188481.1  zinc finger protein 821 isoform 1

    See identical proteins and their annotated locations for NP_001188481.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK296603, AK313693, BC004563, DA324992
    Consensus CDS
    CCDS56006.1
    UniProtKB/Swiss-Prot
    A6NK48, B4DKK4, D3DWS3, O75541
    UniProtKB/TrEMBL
    H3BS68
    Related
    ENSP00000398089.1, ENST00000425432.6
    Conserved Domains (3) summary
    TIGR01642
    Location:275 → 387
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
    sd00017
    Location:120 → 140
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:150 → 172
    zf-C2H2; Zinc finger, C2H2 type

  2. NM_001201553.1 → NP_001188482.1  zinc finger protein 821 isoform 1

    See identical proteins and their annotated locations for NP_001188482.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AC009127, AK296603, BC004563
    Consensus CDS
    CCDS56006.1
    UniProtKB/Swiss-Prot
    A6NK48, B4DKK4, D3DWS3, O75541
    UniProtKB/TrEMBL
    H3BS68
    Related
    ENSP00000455648.1, ENST00000565601.5
    Conserved Domains (3) summary
    TIGR01642
    Location:275 → 387
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
    sd00017
    Location:120 → 140
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:150 → 172
    zf-C2H2; Zinc finger, C2H2 type

  3. NM_001201554.1 → NP_001188483.1  zinc finger protein 821 isoform 2

    See identical proteins and their annotated locations for NP_001188483.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an exon in the 5' coding region, but maintains the reading frame, compared to variant 1. Variants 3 and 4 encode the same isoform (2), which is shorter than isoform 1.
    Source sequence(s)
    BC004563, BC012116, BC091492, DA324992
    Consensus CDS
    CCDS32481.1
    UniProtKB/TrEMBL
    A0A0C4DH12, H3BS68
    Related
    ENSP00000313822.6, ENST00000313565.10
    Conserved Domains (2) summary
    TIGR01642
    Location:233 → 345
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
    sd00017
    Location:78 → 98
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. NM_001201556.1 → NP_001188485.1  zinc finger protein 821 isoform 3

    See identical proteins and their annotated locations for NP_001188485.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an exon in the 3' coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (3) has a shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AK296603, AK313693, AL538838, BC004563, BC091492, DA324992
    Consensus CDS
    CCDS73911.1
    UniProtKB/TrEMBL
    A0A087WXX1, H3BQE4
    Related
    ENSP00000481362.1, ENST00000611294.4

  5. NM_001318238.2 → NP_001305167.1  zinc finger protein 821 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. Variants 6 and 7 encode the same isoform (4), which is shorter than isoform 1.
    Source sequence(s)
    AC009127, BC004563, BC091492
    Conserved Domains (2) summary
    TIGR01642
    Location:125 → 237
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
    sd00017
    Location:2 → 22
    ZF_C2H2; C2H2 Zn finger [structural motif]

  6. NM_001318239.2 → NP_001305168.1  zinc finger protein 821 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. Variants 6 and 7 encode the same isoform (4), which is shorter than isoform 1.
    Source sequence(s)
    BC091492
    Conserved Domains (2) summary
    TIGR01642
    Location:125 → 237
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
    sd00017
    Location:2 → 22
    ZF_C2H2; C2H2 Zn finger [structural motif]

  7. NM_001376297.1 → NP_001363226.1  zinc finger protein 821 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC009127, AC010653
    Consensus CDS
    CCDS56006.1
    UniProtKB/Swiss-Prot
    A6NK48, B4DKK4, D3DWS3, O75541
    UniProtKB/TrEMBL
    H3BS68
    Conserved Domains (3) summary
    TIGR01642
    Location:275 → 387
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
    sd00017
    Location:120 → 140
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:150 → 172
    zf-C2H2; Zinc finger, C2H2 type

  8. NM_001376298.1 → NP_001363227.1  zinc finger protein 821 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC009127, AC010653
    Consensus CDS
    CCDS56006.1
    UniProtKB/Swiss-Prot
    A6NK48, B4DKK4, D3DWS3, O75541
    UniProtKB/TrEMBL
    H3BS68
    Related
    ENSP00000456563.1, ENST00000568666.5
    Conserved Domains (3) summary
    TIGR01642
    Location:275 → 387
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
    sd00017
    Location:120 → 140
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:150 → 172
    zf-C2H2; Zinc finger, C2H2 type

  9. NM_001376299.1 → NP_001363228.1  zinc finger protein 821 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC009127, AC010653
    Consensus CDS
    CCDS56006.1
    UniProtKB/Swiss-Prot
    A6NK48, B4DKK4, D3DWS3, O75541
    UniProtKB/TrEMBL
    H3BS68
    Conserved Domains (3) summary
    TIGR01642
    Location:275 → 387
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
    sd00017
    Location:120 → 140
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:150 → 172
    zf-C2H2; Zinc finger, C2H2 type

  10. NM_001376300.1 → NP_001363229.1  zinc finger protein 821 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC009127, AC010653
    Consensus CDS
    CCDS32481.1
    UniProtKB/TrEMBL
    A0A0C4DH12, H3BS68
    Conserved Domains (2) summary
    TIGR01642
    Location:233 → 345
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
    sd00017
    Location:78 → 98
    ZF_C2H2; C2H2 Zn finger [structural motif]

  11. NM_017530.2 → NP_060000.1  zinc finger protein 821 isoform 2

    See identical proteins and their annotated locations for NP_060000.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks an exon in the 5' coding region, but maintains the reading frame, compared to variant 1. Variants 3 and 4 encode the same isoform (2), which is shorter than isoform 1.
    Source sequence(s)
    AF070588, AK296603, BC004563
    Consensus CDS
    CCDS32481.1
    UniProtKB/TrEMBL
    A0A0C4DH12, H3BS68
    Related
    ENSP00000405908.2, ENST00000446827.6
    Conserved Domains (2) summary
    TIGR01642
    Location:233 → 345
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
    sd00017
    Location:78 → 98
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    71859680..71895256 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047434342.1 → XP_047290298.1  zinc finger protein 821 isoform X1

    UniProtKB/Swiss-Prot
    A6NK48, B4DKK4, D3DWS3, O75541

  2. XM_047434347.1 → XP_047290303.1  zinc finger protein 821 isoform X3

  3. XM_011523212.4 → XP_011521514.1  zinc finger protein 821 isoform X2

    Conserved Domains (2) summary
    PHA02586
    Location:294 → 355
    68; prohead core protein; Provisional
    sd00017
    Location:120 → 140
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. XM_047434343.1 → XP_047290299.1  zinc finger protein 821 isoform X3

  5. XM_011523214.3 → XP_011521516.1  zinc finger protein 821 isoform X3

    See identical proteins and their annotated locations for XP_011521516.1

    Conserved Domains (2) summary
    TIGR01642
    Location:125 → 237
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
    sd00017
    Location:2 → 22
    ZF_C2H2; C2H2 Zn finger [structural motif]

  6. XM_047434346.1 → XP_047290302.1  zinc finger protein 821 isoform X3

  7. XM_011523211.4 → XP_011521513.1  zinc finger protein 821 isoform X1

    See identical proteins and their annotated locations for XP_011521513.1

    UniProtKB/Swiss-Prot
    A6NK48, B4DKK4, D3DWS3, O75541
    UniProtKB/TrEMBL
    H3BS68
    Conserved Domains (3) summary
    TIGR01642
    Location:275 → 387
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
    sd00017
    Location:120 → 140
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:150 → 172
    zf-C2H2; Zinc finger, C2H2 type

  8. XM_047434345.1 → XP_047290301.1  zinc finger protein 821 isoform X3

  9. XM_047434344.1 → XP_047290300.1  zinc finger protein 821 isoform X3

  10. XM_017023422.2 → XP_016878911.1  zinc finger protein 821 isoform X3

    Conserved Domains (2) summary
    TIGR01642
    Location:125 → 237
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
    sd00017
    Location:2 → 22
    ZF_C2H2; C2H2 Zn finger [structural motif]

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    77676829..77701807 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054313429.1 → XP_054169404.1  zinc finger protein 821 isoform X3

  2. XM_054313422.1 → XP_054169397.1  zinc finger protein 821 isoform X2

  3. XM_054313424.1 → XP_054169399.1  zinc finger protein 821 isoform X3

  4. XM_054313423.1 → XP_054169398.1  zinc finger protein 821 isoform X3

  5. XM_054313428.1 → XP_054169403.1  zinc finger protein 821 isoform X3

  6. XM_054313421.1 → XP_054169396.1  zinc finger protein 821 isoform X1

    UniProtKB/Swiss-Prot
    A6NK48, B4DKK4, D3DWS3, O75541

  7. XM_054313427.1 → XP_054169402.1  zinc finger protein 821 isoform X3

  8. XM_054313425.1 → XP_054169400.1  zinc finger protein 821 isoform X3

  9. XM_054313426.1 → XP_054169401.1  zinc finger protein 821 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O75541.3 GenPept UniProtKB/Swiss-Prot:O75541

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