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MIOX myo-inositol oxygenase [ Homo sapiens (human) ]

Gene ID: 55586, updated on 2-Nov-2024

Summary

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Official Symbol
MIOXprovided by HGNC
Official Full Name
myo-inositol oxygenaseprovided by HGNC
Primary source
HGNC:HGNC:14522
See related
Ensembl:ENSG00000100253 MIM:606774; AllianceGenome:HGNC:14522
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ALDRL6
Summary
Enables ferric iron binding activity and inositol oxygenase activity. Involved in inositol catabolic process. Predicted to be located in cytoplasm and inclusion body. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward kidney (RPKM 162.3) See more
Orthologs
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Genomic context

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See MIOX in Genome Data Viewer
Location:
22q13.33
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (50486859..50490648)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (50996041..50999830)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (50925288..50929077)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene protein phosphatase 6 regulatory subunit 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:50883030-50883876 Neighboring gene SET binding factor 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19320 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:50910985-50911896 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:50911897-50912806 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13979 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:50913717-50914626 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13981 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13982 Neighboring gene adrenomedullin 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19321 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13983 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13984 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:50955745-50956678 Neighboring gene lipase maturation factor 2 Neighboring gene non-SMC condensin II complex subunit H2 Neighboring gene synthesis of cytochrome C oxidase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Polymorphisms of myo-inositol oxygenase gene are associated with Type 1 diabetes mellitus. Yang B, et al. J Diabetes Complications, 2010 Nov-Dec. PMID 19896870
  2. myo-inositol oxygenase from rat kidneys. Substrate-dependent oligomerization. Koller F, et al. Eur J Biochem, 1990 Oct 24. PMID 2226462
  3. The inositol phospholipids: a stereochemical view of biological activity. Parthasarathy R, et al. Biochem J, 1986 Apr 15. PMID 3017301, Free PMC Article
  4. Up-regulation of human myo-inositol oxygenase by hyperosmotic stress in renal proximal tubular epithelial cells. Prabhu KS, et al. J Biol Chem, 2005 May 20. PMID 15778219
  5. MIOX inhibits autophagy to regulate the ROS -driven inhibition of STAT3/c-Myc-mediated epithelial-mesenchymal transition in clear cell renal cell carcinoma. Meng L, et al. Redox Biol, 2023 Dec. PMID 37977044, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MIOX inhibits autophagy to regulate the ROS -driven inhibition of STAT3/c-Myc-mediated epithelial-mesenchymal transition in clear cell renal cell carcinoma.
    Title: MIOX inhibits autophagy to regulate the ROS -driven inhibition of STAT3/c-Myc-mediated epithelial-mesenchymal transition in clear cell renal cell carcinoma.
  2. Myo-inositol oxygenase (MIOX) accelerated inflammation in the model of infection-induced cardiac dysfunction by NLRP3 inflammasome.
    Title: Myo-inositol oxygenase (MIOX) accelerated inflammation in the model of infection-induced cardiac dysfunction by NLRP3 inflammasome.
  3. Long noncoding RNA NEAT1 promotes ferroptosis by modulating the miR-362-3p/MIOX axis as a ceRNA.
    Title: Long noncoding RNA NEAT1 promotes ferroptosis by modulating the miR-362-3p/MIOX axis as a ceRNA.
  4. Myo-inositol Oxygenase (MIOX) Overexpression Drives the Progression of Renal Tubulointerstitial Injury in Diabetes.
    Title: Myo-inositol Oxygenase (MIOX) Overexpression Drives the Progression of Renal Tubulointerstitial Injury in Diabetes.
  5. MIOX-induced oxidant stress and tunicamycin-induced endoplasmic reticulum stress are interlinked, and both of the events may feed into each other to amplify the tubulointerstitial injury.
    Title: Myo-inositol oxygenase accentuates renal tubular injury initiated by endoplasmic reticulum stress.
  6. increased MIOX expression in the kidney contributes to tubular damage in DN (Diabetic Nephropathy). The concentration of MIOX in the serum and urine may serve as a new biomarker for the early diagnosis of DN.
    Title: The Kidney Specific Protein myo-Inositol Oxygenase, a Potential Biomarker for Diabetic Nephropathy.
  7. Our results suggest that serum MIOX levels do not change in polycystic ovary syndrome. It was, therefore, concluded that myoinositol deficiency observed in PCOS was not related to the level of MIOX enzyme which cleaves myoinositol.
    Title: Does myo-inositol oxygenase, the only enzyme to catalyze myo-inositol in vivo, play a role in the etiology of polycystic ovarian syndrome?
  8. these findings highlight the epigenetic regulation of MIOX in the pathogenesis of diabetic tubulopathy.
    Title: High Glucose-Induced Hypomethylation Promotes Binding of Sp-1 to Myo-Inositol Oxygenase: Implication in the Pathobiology of Diabetic Tubulopathy.
  9. Data suggest that MIOX expression/activity is up-regulated in kidneys tubules during oxidative stress (as in obesity and diabetic nephropathy); up-regulation of MIOX activity is related to phosphorylation of serine/threonine residues.
    Title: Transcriptional and Translational Modulation of myo-Inositol Oxygenase (Miox) by Fatty Acids: IMPLICATIONS IN RENAL TUBULAR INJURY INDUCED IN OBESITY AND DIABETES.
  10. results demonstrated that the polymorphism (rs761745) in the promoter region of myo-inositol oxygenase(MIOX) gene may be associated with the development of type 1 diabetes mellitus in our studied population
    Title: Polymorphisms of myo-inositol oxygenase gene are associated with Type 1 diabetes mellitus.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC90217

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables aldo-keto reductase (NADPH) activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ferric iron binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables inositol oxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables inositol oxygenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables inositol oxygenase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables oxidoreductase activity, acting on NAD(P)H IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in inositol catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in inositol catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in inositol catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in inclusion body ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
inositol oxygenase
Names
MI oxygenase
aldehyde reductase (aldose reductase) like 6
aldehyde reductase-like 6
kidney-specific protein 32
renal-specific oxidoreductase
NP_060054.4
XP_005261982.1
XP_011529007.1
XP_047297399.1
XP_054181762.1
XP_054181763.1
XP_054181764.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017584.6 → NP_060054.4  inositol oxygenase

    See identical proteins and their annotated locations for NP_060054.4

    Status: VALIDATED

    Source sequence(s)
    AF197129, AL096767, BC012025, BC064395
    Consensus CDS
    CCDS14092.1
    UniProtKB/Swiss-Prot
    Q05DJ6, Q5S8C9, Q9BZZ1, Q9UGB7, Q9UHB8
    UniProtKB/TrEMBL
    A6PVH4
    Related
    ENSP00000216075.6, ENST00000216075.11
    Conserved Domains (1) summary
    pfam05153
    Location:37 → 285
    MIOX; Myo-inositol oxygenase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    50486859..50490648
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047441443.1 → XP_047297399.1  inositol oxygenase isoform X3

    Related
    ENSP00000379082.3, ENST00000395733.7

  2. XM_011530705.3 → XP_011529007.1  inositol oxygenase isoform X2

    Conserved Domains (1) summary
    pfam05153
    Location:37 → 113
    MIOX; Myo-inositol oxygenase

  3. XM_005261925.5 → XP_005261982.1  inositol oxygenase isoform X1

    UniProtKB/TrEMBL
    A6PVH4
    Conserved Domains (1) summary
    pfam05153
    Location:1 → 239
    MIOX; Myo-inositol oxygenase

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    50996041..50999830
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054325789.1 → XP_054181764.1  inositol oxygenase isoform X3

  2. XM_054325788.1 → XP_054181763.1  inositol oxygenase isoform X2

  3. XM_054325787.1 → XP_054181762.1  inositol oxygenase isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UGB7.1 GenPept UniProtKB/Swiss-Prot:Q9UGB7

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