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PKIB cAMP-dependent protein kinase inhibitor beta [ Homo sapiens (human) ]

Gene ID: 5570, updated on 3-Apr-2024

Summary

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Official Symbol
PKIBprovided by HGNC
Official Full Name
cAMP-dependent protein kinase inhibitor betaprovided by HGNC
Primary source
HGNC:HGNC:9018
See related
Ensembl:ENSG00000135549 MIM:606914; AllianceGenome:HGNC:9018
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PRKACN2
Summary
This gene encodes a member of the cAMP-dependent protein kinase inhibitor family. The encoded protein may play a role in the protein kinase A (PKA) pathway by interacting with the catalytic subunit of PKA, and overexpression of this gene may play a role in prostate cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Expression
Biased expression in colon (RPKM 18.8), placenta (RPKM 15.5) and 10 other tissues See more
Orthologs
mouse all
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Genomic context

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See PKIB in Genome Data Viewer
Location:
6q22.31
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (122471921..122726373)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (123660238..123914654)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (122793066..123047518)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17514 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:122721093-122721592 Neighboring gene heat shock transcription factor 2 Neighboring gene serine incorporator 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25020 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25021 Neighboring gene uncharacterized LOC124901391 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:122884938-122885474 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:122884400-122884937 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17516 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:122932197-122932842 Neighboring gene MPRA-validated peak6076 silencer Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:123017072-123018271 Neighboring gene MPRA-validated peak6077 silencer Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr6:123076853-123077432 Neighboring gene RNA, 7SL, cytoplasmic 564, pseudogene Neighboring gene fatty acid binding protein 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Downregulation of cAMP-Dependent Protein Kinase Inhibitor-b Promotes Preeclampsia by Decreasing Phosphorylated Akt. Liu C, et al. Reprod Sci, 2021 Jan. PMID 32676926, Free PMC Article
  2. PKIB promotes cell proliferation and the invasion-metastasis cascade through the PI3K/Akt pathway in NSCLC cells. Dou P, et al. Exp Biol Med (Maywood), 2016 Nov. PMID 27325557, Free PMC Article
  3. PKIB expression strongly correlated with phosphorylated Akt expression in breast cancers and also with triple-negative breast cancer subtype. Dabanaka K, et al. Med Mol Morphol, 2012 Dec. PMID 23224602
  4. [Expression and characterizations of a novel full-length gene PKIbeta related to human glioma]. Qi ZY, et al. Zhonghua Yi Xue Za Zhi, 2008 Jul 1. PMID 19035091
  5. Protein kinase inhibitor β enhances the constitutive activity of G-protein-coupled zinc receptor GPR39. Kovacs Z, et al. Biochem J, 2014 Aug 15. PMID 24869658

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Downregulation of cAMP-Dependent Protein Kinase Inhibitor-b Promotes Preeclampsia by Decreasing Phosphorylated Akt.
    Title: Downregulation of cAMP-Dependent Protein Kinase Inhibitor-b Promotes Preeclampsia by Decreasing Phosphorylated Akt.
  2. results indicate that PKIB promotes cell proliferation and tumorigenesis by activating the PI3K/Akt pathway in non-small cell lung cancer (NSCLC), implying that this is an important underlying mechanism that affects the progression of NSCLC
    Title: PKIB promotes cell proliferation and the invasion-metastasis cascade through the PI3K/Akt pathway in NSCLC cells.
  3. mutation of the pseudosubstrate domain abolished the inhibitory activity of PKIB on protein kinase A activity, but had no effect on the interaction with GPR39, cell protection and induction of SRE-dependent transcription
    Title: Protein kinase inhibitor β enhances the constitutive activity of G-protein-coupled zinc receptor GPR39.
  4. PKIB overexpression was strongly correlated with pAkt expression and triple-negative breast cancer, suggesting that PKIB overexpression might contribute to the tumor behavior and development of breast cancers.
    Title: PKIB expression strongly correlated with phosphorylated Akt expression in breast cancers and also with triple-negative breast cancer subtype.
  5. Findings show that PKIB and PKA-C kinase can have critical functions of aggressive phenotype of PCs through Akt phosphorylation and that they should be a promising molecular target for PC treatment.
    Title: Overexpressing PKIB in prostate cancer promotes its aggressiveness by linking between PKA and Akt pathways.
  6. PKIbeta may be a novel full-length gene related to human glioma and may provide a new way to gene therapy of glioma.
    Title: [Expression and characterizations of a novel full-length gene PKIbeta related to human glioma].
  7. human PKIbeta gene (clone 436F11, GenBank with accession number: AF225513) was over-expressed in normal brain tissues
    Title: Isolation of novel differentially expressed genes related to human glioma using cDNA microarray and characterizations of two novel full-length genes.
  8. Functional studies of the rat homolog
    Title: Molecular cloning of a rat testis form of the inhibitor protein of cAMP-dependent protein kinase.
  9. Functional studies of the mouse homolog
    Title: Evidence for two additional isoforms of the endogenous protein kinase inhibitor of cAMP-dependent protein kinase in mouse.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of protein kinase (cAMP-dependent, catalytic) inhibitor beta (PKIB) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ23817, DKFZp781K1114

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cAMP-dependent protein kinase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of cAMP-dependent protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of telomerase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of telomere capping IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of telomere maintenance via telomerase IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cAMP-dependent protein kinase inhibitor beta
Names
PKI-beta
cAMP-dependent protein kinase inhibitor 2
protein kinase (cAMP-dependent, catalytic) inhibitor beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270393.2 → NP_001257322.1  cAMP-dependent protein kinase inhibitor beta isoform 1

    See identical proteins and their annotated locations for NP_001257322.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3 and 4 encode the same isoform (1).
    Source sequence(s)
    AL512283, BG507119, BM802552, BM969901, BU753807
    Consensus CDS
    CCDS5126.1
    UniProtKB/Swiss-Prot
    B2RCK2, Q567T9, Q5T0Z7, Q9C010
    Conserved Domains (1) summary
    pfam02827
    Location:9 → 77
    PKI; cAMP-dependent protein kinase inhibitor

  2. NM_001270394.2 → NP_001257323.1  cAMP-dependent protein kinase inhibitor beta isoform 2

    See identical proteins and their annotated locations for NP_001257323.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. Variants 5 and 6 encode the same isoform (2), which is longer and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AL512283, BC036011, BG507119, BM802552, BU753807
    Consensus CDS
    CCDS59033.1
    Related
    ENSP00000480824.1, ENST00000615438.4
    Conserved Domains (1) summary
    pfam02827
    Location:16 → 84
    PKI; cAMP-dependent protein kinase inhibitor

  3. NM_001270395.2 → NP_001257324.1  cAMP-dependent protein kinase inhibitor beta isoform 2

    See identical proteins and their annotated locations for NP_001257324.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. Variants 5 and 6 encode the same isoform (2), which is longer and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AL512283, BC036011, BP262756, BU753807
    Consensus CDS
    CCDS59033.1
    Related
    ENSP00000258014.3, ENST00000258014.3
    Conserved Domains (1) summary
    pfam02827
    Location:16 → 84
    PKI; cAMP-dependent protein kinase inhibitor

  4. NM_032471.6 → NP_115860.1  cAMP-dependent protein kinase inhibitor beta isoform 1

    See identical proteins and their annotated locations for NP_115860.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3 and 4 encode the same isoform (1).
    Source sequence(s)
    AL512283, BC036011, BU753807
    Consensus CDS
    CCDS5126.1
    UniProtKB/Swiss-Prot
    B2RCK2, Q567T9, Q5T0Z7, Q9C010
    Related
    ENSP00000376280.1, ENST00000392490.5
    Conserved Domains (1) summary
    pfam02827
    Location:9 → 77
    PKI; cAMP-dependent protein kinase inhibitor

  5. NM_181794.3 → NP_861459.1  cAMP-dependent protein kinase inhibitor beta isoform 1

    See identical proteins and their annotated locations for NP_861459.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3 and 4 encode the same isoform (1).
    Source sequence(s)
    AJ420562, AL512283, BG507119, BU753807
    Consensus CDS
    CCDS5126.1
    UniProtKB/Swiss-Prot
    B2RCK2, Q567T9, Q5T0Z7, Q9C010
    Related
    ENSP00000376281.1, ENST00000392491.6
    Conserved Domains (1) summary
    pfam02827
    Location:9 → 77
    PKI; cAMP-dependent protein kinase inhibitor

  6. NM_181795.3 → NP_861460.1  cAMP-dependent protein kinase inhibitor beta isoform 1

    See identical proteins and their annotated locations for NP_861460.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the shorter isoform (1). Variants 1, 2, 3 and 4 encode the same isoform.
    Source sequence(s)
    AK315151, AL512283, BP260889, BU753807
    Consensus CDS
    CCDS5126.1
    UniProtKB/Swiss-Prot
    B2RCK2, Q567T9, Q5T0Z7, Q9C010
    Related
    ENSP00000357437.2, ENST00000368452.7
    Conserved Domains (1) summary
    pfam02827
    Location:9 → 77
    PKI; cAMP-dependent protein kinase inhibitor

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    122471921..122726373
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047419002.1 → XP_047274958.1  cAMP-dependent protein kinase inhibitor beta isoform X1

  2. XM_011535933.4 → XP_011534235.1  cAMP-dependent protein kinase inhibitor beta isoform X1

    See identical proteins and their annotated locations for XP_011534235.1

    Conserved Domains (1) summary
    pfam02827
    Location:16 → 84
    PKI; cAMP-dependent protein kinase inhibitor

  3. XM_047419003.1 → XP_047274959.1  cAMP-dependent protein kinase inhibitor beta isoform X1

  4. XM_047419005.1 → XP_047274961.1  cAMP-dependent protein kinase inhibitor beta isoform X2

    UniProtKB/Swiss-Prot
    B2RCK2, Q567T9, Q5T0Z7, Q9C010

  5. XM_047419006.1 → XP_047274962.1  cAMP-dependent protein kinase inhibitor beta isoform X2

    UniProtKB/Swiss-Prot
    B2RCK2, Q567T9, Q5T0Z7, Q9C010

  6. XM_011535930.4 → XP_011534232.1  cAMP-dependent protein kinase inhibitor beta isoform X1

    See identical proteins and their annotated locations for XP_011534232.1

    Conserved Domains (1) summary
    pfam02827
    Location:16 → 84
    PKI; cAMP-dependent protein kinase inhibitor

  7. XM_011535932.4 → XP_011534234.1  cAMP-dependent protein kinase inhibitor beta isoform X1

    See identical proteins and their annotated locations for XP_011534234.1

    Conserved Domains (1) summary
    pfam02827
    Location:16 → 84
    PKI; cAMP-dependent protein kinase inhibitor

  8. XM_047419004.1 → XP_047274960.1  cAMP-dependent protein kinase inhibitor beta isoform X1

  9. XM_011535937.3 → XP_011534239.1  cAMP-dependent protein kinase inhibitor beta isoform X2

    See identical proteins and their annotated locations for XP_011534239.1

    UniProtKB/Swiss-Prot
    B2RCK2, Q567T9, Q5T0Z7, Q9C010
    Related
    ENSP00000346227.2, ENST00000354275.2
    Conserved Domains (1) summary
    pfam02827
    Location:9 → 77
    PKI; cAMP-dependent protein kinase inhibitor

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    123660238..123914654
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054355842.1 → XP_054211817.1  cAMP-dependent protein kinase inhibitor beta isoform X1

  2. XM_054355841.1 → XP_054211816.1  cAMP-dependent protein kinase inhibitor beta isoform X1

  3. XM_054355844.1 → XP_054211819.1  cAMP-dependent protein kinase inhibitor beta isoform X2

    UniProtKB/Swiss-Prot
    B2RCK2, Q567T9, Q5T0Z7, Q9C010

  4. XM_054355839.1 → XP_054211814.1  cAMP-dependent protein kinase inhibitor beta isoform X1

  5. XM_054355840.1 → XP_054211815.1  cAMP-dependent protein kinase inhibitor beta isoform X1

  6. XM_054355843.1 → XP_054211818.1  cAMP-dependent protein kinase inhibitor beta isoform X1

  7. XM_054355845.1 → XP_054211820.1  cAMP-dependent protein kinase inhibitor beta isoform X2

    UniProtKB/Swiss-Prot
    B2RCK2, Q567T9, Q5T0Z7, Q9C010
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9C010.1 GenPept UniProtKB/Swiss-Prot:Q9C010

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