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FIRRM FIGNL1 interacting regulator of recombination and mitosis [ Homo sapiens (human) ]

Gene ID: 55732, updated on 2-Nov-2024

Summary

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Official Symbol
FIRRMprovided by HGNC
Official Full Name
FIGNL1 interacting regulator of recombination and mitosisprovided by HGNC
Primary source
HGNC:HGNC:25565
See related
Ensembl:ENSG00000000460 AllianceGenome:HGNC:25565
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FLIP; Apolo1; MEICA1; C1orf112
Summary
Enables protein kinase binding activity. Involved in several processes, including chromosome segregation; interstrand cross-link repair; and regulation of protein kinase activity. Located in several cellular components, including kinetochore; midbody; and spindle midzone. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis (RPKM 5.7), lymph node (RPKM 3.2) and 24 other tissues See more
Orthologs
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Genomic context

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See FIRRM in Genome Data Viewer
Location:
1q24.2
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (169783837..169854080)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (169139615..169209809)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (169763871..169823221)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene selectin E Neighboring gene uncharacterized LOC101928628 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:169751147-169751648 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2079 Neighboring gene methyltransferase 18, RPL3 N3(tau)-histidine Neighboring gene MPRA-validated peak450 silencer Neighboring gene RNA, 7SL, cytoplasmic 333, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2080 Neighboring gene SCY1 like pseudokinase 3 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:169862205-169862792 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:169862793-169863380 Neighboring gene VISTA enhancer hs1442 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:169914181-169914349 Neighboring gene kinesin associated protein 3 Neighboring gene RNA, 7SL, cytoplasmic 269, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FLIP(C1orf112)-FIGNL1 complex regulates RAD51 chromatin association to promote viability after replication stress.
    Title: FLIP(C1orf112)-FIGNL1 complex regulates RAD51 chromatin association to promote viability after replication stress.
  2. Feedback control of PLK1 by Apolo1 ensures accurate chromosome segregation.
    Title: Feedback control of PLK1 by Apolo1 ensures accurate chromosome segregation.
  3. Knockdown of C1orf112 by siRNA in HeLa cells significantly suppressed their growth.
    Title: GeneFriends: an online co-expression analysis tool to identify novel gene targets for aging and complex diseases.
  4. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  5. Observational study of gene-disease association. (HuGE Navigator)
    Title: Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ10706, FLJ13470, MGC130018, MGC130019

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromosome segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in interstrand cross-link repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of protein kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome, centromeric region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
located_in midbody IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in spindle midzone IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
FIGNL1-interacting regulator of recombination and mitosis
Names
Fidgetin-like-1 interacting protein
POLO1-associating protein
associating protein with POLO1
uncharacterized protein C1orf112

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320047.2 → NP_001306976.1  FIGNL1-interacting regulator of recombination and mitosis isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL031297, BC091516, DA770714, DC401980
    Consensus CDS
    CCDS1285.1
    UniProtKB/Swiss-Prot
    A6NFP1, B3KU42, Q3KNQ1, Q9H8L5, Q9NSG2, Q9NVJ0
    UniProtKB/TrEMBL
    B4DGF2
    Related
    ENSP00000352276.4, ENST00000359326.9
    Conserved Domains (1) summary
    pfam14868
    Location:176 → 728
    DUF4487; Domain of unknown function (DUF4487)

  2. NM_001320048.2 → NP_001306977.1  FIGNL1-interacting regulator of recombination and mitosis isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK001568, AK303296, AL031297, BC091516
    UniProtKB/TrEMBL
    B4DGF2
    Conserved Domains (1) summary
    pfam14868
    Location:41 → 593
    DUF4487; Domain of unknown function (DUF4487)

  3. NM_001320050.2 → NP_001306979.1  FIGNL1-interacting regulator of recombination and mitosis isoform 3

    Status: VALIDATED

    Source sequence(s)
    AK096493, BC011012, BC011445, CB159947, DC401980
    Consensus CDS
    CCDS81400.1
    UniProtKB/TrEMBL
    A0A1B0GV14
    Related
    ENSP00000490333.1, ENST00000496973.5

  4. NM_001320051.2 → NP_001306980.1  FIGNL1-interacting regulator of recombination and mitosis isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL354614, BC011445, BC091516, CB159947
    Consensus CDS
    CCDS81401.1
    UniProtKB/TrEMBL
    A0A1B0GUP7
    Related
    ENSP00000490194.1, ENST00000472795.5

  5. NM_001363739.2 → NP_001350668.1  FIGNL1-interacting regulator of recombination and mitosis isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL021940, AL031297
    Consensus CDS
    CCDS86030.1
    Conserved Domains (1) summary
    pfam14868
    Location:1 → 405
    DUF4487; Domain of unknown function (DUF4487)

  6. NM_001366768.1 → NP_001353697.1  FIGNL1-interacting regulator of recombination and mitosis isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL021940, AL031297
    UniProtKB/TrEMBL
    B4DGF2

  7. NM_001366769.1 → NP_001353698.1  FIGNL1-interacting regulator of recombination and mitosis isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL021940, AL031297
    UniProtKB/TrEMBL
    B4DGF2
    Conserved Domains (1) summary
    pfam14868
    Location:234 → 786
    DUF4487; Domain of unknown function (DUF4487)

  8. NM_001366770.1 → NP_001353699.1  FIGNL1-interacting regulator of recombination and mitosis isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL021940, AL031297
    UniProtKB/TrEMBL
    B4DGF2

  9. NM_001366771.1 → NP_001353700.1  FIGNL1-interacting regulator of recombination and mitosis isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL021940, AL031297
    Consensus CDS
    CCDS86030.1
    Conserved Domains (1) summary
    pfam14868
    Location:1 → 405
    DUF4487; Domain of unknown function (DUF4487)

  10. NM_001366772.1 → NP_001353701.1  FIGNL1-interacting regulator of recombination and mitosis isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL021940, AL031297
    Consensus CDS
    CCDS86030.1
    Related
    ENSP00000389257.3, ENST00000413811.3
    Conserved Domains (1) summary
    pfam14868
    Location:1 → 405
    DUF4487; Domain of unknown function (DUF4487)

  11. NM_001366773.1 → NP_001353702.1  FIGNL1-interacting regulator of recombination and mitosis isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL021940, AL031297
    Consensus CDS
    CCDS86030.1
    Conserved Domains (1) summary
    pfam14868
    Location:1 → 405
    DUF4487; Domain of unknown function (DUF4487)

RNA

  1. NR_159440.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL021940, AL031297
    Related
    ENST00000459772.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    169783837..169854080
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047424760.1 → XP_047280716.1  FIGNL1-interacting regulator of recombination and mitosis isoform X1

    UniProtKB/Swiss-Prot
    A6NFP1, B3KU42, Q3KNQ1, Q9H8L5, Q9NSG2, Q9NVJ0

  2. XM_047424762.1 → XP_047280718.1  FIGNL1-interacting regulator of recombination and mitosis isoform X1

    UniProtKB/Swiss-Prot
    A6NFP1, B3KU42, Q3KNQ1, Q9H8L5, Q9NSG2, Q9NVJ0

  3. XM_047424751.1 → XP_047280707.1  FIGNL1-interacting regulator of recombination and mitosis isoform X1

    UniProtKB/Swiss-Prot
    A6NFP1, B3KU42, Q3KNQ1, Q9H8L5, Q9NSG2, Q9NVJ0

  4. XM_047424770.1 → XP_047280726.1  FIGNL1-interacting regulator of recombination and mitosis isoform X3

  5. XM_047424752.1 → XP_047280708.1  FIGNL1-interacting regulator of recombination and mitosis isoform X1

    UniProtKB/Swiss-Prot
    A6NFP1, B3KU42, Q3KNQ1, Q9H8L5, Q9NSG2, Q9NVJ0

  6. XM_047424743.1 → XP_047280699.1  FIGNL1-interacting regulator of recombination and mitosis isoform X1

    UniProtKB/Swiss-Prot
    A6NFP1, B3KU42, Q3KNQ1, Q9H8L5, Q9NSG2, Q9NVJ0
    Related
    ENSP00000286031.6, ENST00000286031.10

  7. XM_047424759.1 → XP_047280715.1  FIGNL1-interacting regulator of recombination and mitosis isoform X1

    UniProtKB/Swiss-Prot
    A6NFP1, B3KU42, Q3KNQ1, Q9H8L5, Q9NSG2, Q9NVJ0

  8. XM_017001723.2 → XP_016857212.1  FIGNL1-interacting regulator of recombination and mitosis isoform X2

    UniProtKB/TrEMBL
    B4DGF2

  9. XM_047424771.1 → XP_047280727.1  FIGNL1-interacting regulator of recombination and mitosis isoform X4

RNA

  1. XR_921872.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    169139615..169209809
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054337570.1 → XP_054193545.1  FIGNL1-interacting regulator of recombination and mitosis isoform X1

    UniProtKB/Swiss-Prot
    A6NFP1, B3KU42, Q3KNQ1, Q9H8L5, Q9NSG2, Q9NVJ0

  2. XM_054337571.1 → XP_054193546.1  FIGNL1-interacting regulator of recombination and mitosis isoform X1

    UniProtKB/Swiss-Prot
    A6NFP1, B3KU42, Q3KNQ1, Q9H8L5, Q9NSG2, Q9NVJ0

  3. XM_054337567.1 → XP_054193542.1  FIGNL1-interacting regulator of recombination and mitosis isoform X1

    UniProtKB/Swiss-Prot
    A6NFP1, B3KU42, Q3KNQ1, Q9H8L5, Q9NSG2, Q9NVJ0

  4. XM_054337568.1 → XP_054193543.1  FIGNL1-interacting regulator of recombination and mitosis isoform X1

    UniProtKB/Swiss-Prot
    A6NFP1, B3KU42, Q3KNQ1, Q9H8L5, Q9NSG2, Q9NVJ0

  5. XM_054337573.1 → XP_054193548.1  FIGNL1-interacting regulator of recombination and mitosis isoform X3

  6. XM_054337569.1 → XP_054193544.1  FIGNL1-interacting regulator of recombination and mitosis isoform X1

    UniProtKB/Swiss-Prot
    A6NFP1, B3KU42, Q3KNQ1, Q9H8L5, Q9NSG2, Q9NVJ0

  7. XM_054337572.1 → XP_054193547.1  FIGNL1-interacting regulator of recombination and mitosis isoform X2

  8. XM_054337574.1 → XP_054193549.1  FIGNL1-interacting regulator of recombination and mitosis isoform X4

RNA

  1. XR_008486103.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_018186.3: Suppressed sequence

    Description
    NM_018186.3: This RefSeq has been removed because currently there is insufficient support for the transcript.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NSG2.1 GenPept UniProtKB/Swiss-Prot:Q9NSG2

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