PARVA parvin alpha [Homo sapiens (human)] - Gene

Summary

Official Symbol: PARVAprovided by HGNC
Official Full Name: parvin alphaprovided by HGNC
Primary source: HGNC:HGNC:14652
See related: Ensembl:ENSG00000197702 MIM:608120; AllianceGenome:HGNC:14652
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MXRA2; CH-ILKBP
Summary: This gene encodes a member of the parvin family of actin-binding proteins. Parvins are associated with focal contacts and contain calponin homology domains that bind to actin filaments. The encoded protein is part of the integrin-linked kinase signaling complex and plays a role in cell adhesion, motility and survival. [provided by RefSeq, Dec 2010]
Expression: Ubiquitous expression in endometrium (RPKM 30.7), fat (RPKM 26.7) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 11p15.3

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (12376436..12535356)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (12468314..12627400)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (12399118..12556903)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Complex structures of Rsu1 and PINCH1 reveal a regulatory mechanism of the ILK/PINCH/Parvin complex for F-actin dynamics.
Title: Complex structures of Rsu1 and PINCH1 reveal a regulatory mechanism of the ILK/PINCH/Parvin complex for F-actin dynamics.
A novel signaling pathway consisting of alpha-parvin, G3BP2, and TWIST1 regulates breast cancer progression and metastasis, this suggests that the activation of this signaling pathway is a key factor for driving the progression and poor clinical outcome of human ER-negative breast cancer.
Title: α-Parvin promotes breast cancer progression and metastasis through interaction with G3BP2 and regulation of TWIST1 signaling.
edited form of miR-378a-3p preferentially binds to the 3'-UTR of the PARVA oncogene and inhibits its expression, thus preventing the progression of melanoma towards the malignant phenotype
Title: A-to-I miR-378a-3p editing can prevent melanoma progression via regulation of PARVA expression.
Protein expression of alpha-Parvin increases with colorectal cancer progression.
Title: Focal Adhesion Proteins α- and β-Parvin are Overexpressed in Human Colorectal Cancer and Correlate with Tumor Progression.
PARVA promotes metastasis by modulating ILK signalling pathway in lung adenocarcinoma
Title: PARVA promotes metastasis by modulating ILK signalling pathway in lung adenocarcinoma.
alpha-pv-deficient HUVECs show reduced stable adherens junctions, decreased monolayer formation, and impaired motility, associated with reduced formation of integrin-mediated cell-extracellular matrix adhesion structures and an altered actin cytoskeleton.
Title: Endothelial alpha-parvin controls integrity of developing vasculature and is required for maintenance of cell-cell junctions.
alpha-Parvin, a pseudopodial constituent, was found to promote migration of breast cancer cells and to be expressed exclusively by Invasive lobular carcinoma
Title: α-Parvin, a pseudopodial constituent, promotes cell motility and is associated with lymph node metastasis of lobular breast carcinoma.
Actopaxin plays a role in hepatocellular carcinoma progression and metastasis, by way of regulation of cell invasiveness and motility, an epithelial-mesenchymal transition process, and chemosensitivity to cytotoxic drugs.
Title: Suppression of actopaxin impairs hepatocellular carcinoma metastasis through modulation of cell migration and invasion.
beta2-adaptin is shown to bind to the focal adhesion protein actopaxin and localize to focal adhesions during cells spreading in an actopaxin dependent manner
Title: Beta2-adaptin binds actopaxin and regulates cell spreading, migration and matrix degradation.
alpha-parvin, beta-parvin and migfilin were expressed in tumor cells in 53%, 2%, 28% and 53% of effusions and 57%, 20%, 83% and 25% of solid lesions, respectively.
Title: Migfilin, α-parvin and β-parvin are differentially expressed in ovarian serous carcinoma effusions, primary tumors and solid metastases.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genomic variation associated with mortality among adults of European and African ancestry with heart failure: the cohorts for heart and aging research in genomic epidemiology consortium. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of parvin, alpha (PARVA) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH16363 (e-PCR)
- UniSTS:44547

NoName (e-PCR)
- UniSTS:9484

STS-N23290 (e-PCR)
- UniSTS:63011

WI-13804 (e-PCR)
- UniSTS:64051

RH94062 (e-PCR)
- UniSTS:90941

G54650 (e-PCR)
- UniSTS:117851

D1S1423 (e-PCR)
- UniSTS:149619

STS-AA037636 (e-PCR)
- UniSTS:122

D11S3101 (e-PCR)
- UniSTS:152195

G59980 (e-PCR)
- UniSTS:137116

RH121016 (e-PCR)
- UniSTS:134068

D11S1049 (e-PCR)
- UniSTS:72628

SHGC-155066 (e-PCR)
- UniSTS:182458

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables actin binding	IBA Inferred from Biological aspect of Ancestor more info
enables cadherin binding	HDA more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase inhibitor activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in actin-mediated cell contraction	ISS Inferred from Sequence or Structural Similarity more info
involved_in cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment or maintenance of cell polarity	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment or maintenance of cell polarity	ISS Inferred from Sequence or Structural Similarity more info
involved_in heterotypic cell-cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in outflow tract septum morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein stabilization	TAS Traceable Author Statement more info	PubMed
involved_in regulation of cell shape	IEA Inferred from Electronic Annotation more info
involved_in smooth muscle cell chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
involved_in sprouting angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in substrate adhesion-dependent cell spreading	IBA Inferred from Biological aspect of Ancestor more info
involved_in substrate adhesion-dependent cell spreading	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Z disc	IEA Inferred from Electronic Annotation more info
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in actin cytoskeleton	IDA Inferred from Direct Assay more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
located_in focal adhesion	HDA more info	PubMed
is_active_in focal adhesion	IBA Inferred from Biological aspect of Ancestor more info
located_in focal adhesion	IDA Inferred from Direct Assay more info	PubMed
located_in lamellipodium	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: alpha-parvin

Names: actopaxin; calponin-like integrin-linked kinase-binding protein; matrix-remodeling-associated protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_018222.5 → NP_060692.3 alpha-parvin

Status: REVIEWED

Source sequence(s)

AC009806, AK001655, CA444306, DC344546

Consensus CDS

CCDS44541.3

UniProtKB/Swiss-Prot

Q96C85, Q9HA48, Q9NVD7

Related

ENSP00000334008.9, ENST00000334956.15

Conserved Domains (2) summary

cd21335
Location:91 → 205

CH_PARVA_rpt1; first calponin homology (CH) domain found in alpha-parvin

cd21337
Location:244 → 372

CH_PARVA_rpt2; second calponin homology (CH) domain found in alpha-parvin

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000011.10 Reference GRCh38.p14 Primary Assembly

Range

12376436..12535356

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005253015.4 → XP_005253072.1 alpha-parvin isoform X1

Conserved Domains (1) summary

pfam00307
Location:52 → 153

CH; Calponin homology (CH) domain