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tbc1d14 TBC1 domain family, member 14 [ Danio rerio (zebrafish) ]

Gene ID: 557744, updated on 18-Sep-2024

Summary

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Official Symbol
tbc1d14provided by ZNC
Official Full Name
TBC1 domain family, member 14provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-6136
See related
Ensembl:ENSDARG00000003520 AllianceGenome:ZFIN:ZDB-GENE-030131-6136
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
sb:eu1004; wu:fi35h01; wu:fi42a03; si:dkey-120m5.1
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in activation of GTPase activity; intracellular protein transport; and regulation of autophagosome assembly. Predicted to be active in autophagosome and recycling endosome. Orthologous to human TBC1D14 (TBC1 domain family member 14). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See tbc1d14 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (39680106..39705766)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (39408885..39432125)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase non-receptor type 5 Neighboring gene KIAA0232 Neighboring gene chemokine (C-C motif) ligand 36, duplicate 1 Neighboring gene si:dkey-58i8.5 Neighboring gene serine/threonine-protein kinase pim-3-like Neighboring gene cilia and flagella associated protein 184

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Evolution and expression of the phosphodiesterase 6 genes unveils vertebrate novelty to control photosensitivity. Lagman D, et al. BMC Evol Biol, 2016 Jun 13. PMID 27296292, Free PMC Article
  2. Characterization of the Apelin/Elabela Receptors (APLNR) in Chickens, Turtles, and Zebrafish: Identification of a Novel Apelin-Specific Receptor in Teleosts. Zhang J, et al. Front Endocrinol (Lausanne), 2018. PMID 30631305, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • KIAA0608

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in autophagosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in recycling endosome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
TBC1 domain family member 14

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    39680106..39705766
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005166439.5 → XP_005166496.1  TBC1 domain family member 14 isoform X1

    See identical proteins and their annotated locations for XP_005166496.1

    UniProtKB/TrEMBL
    A0A8N7TAE1, F6P7J8
    Conserved Domains (2) summary
    COG5210
    Location:293 → 656
    COG5210; GTPase-activating protein [General function prediction only]
    pfam00566
    Location:485 → 651
    RabGAP-TBC; Rab-GTPase-TBC domain

  2. XM_678089.9 → XP_683181.1  TBC1 domain family member 14 isoform X1

    See identical proteins and their annotated locations for XP_683181.1

    UniProtKB/TrEMBL
    A0A8N7TAE1, F6P7J8
    Related
    ENSDARP00000121985.1, ENSDART00000133420.4
    Conserved Domains (2) summary
    COG5210
    Location:293 → 656
    COG5210; GTPase-activating protein [General function prediction only]
    pfam00566
    Location:485 → 651
    RabGAP-TBC; Rab-GTPase-TBC domain

  3. XM_005166440.5 → XP_005166497.1  TBC1 domain family member 14 isoform X2

    UniProtKB/TrEMBL
    A0A8M2BE06
    Related
    ENSDARP00000040945.8, ENSDART00000040946.9
    Conserved Domains (1) summary
    pfam00566
    Location:186 → 352
    RabGAP-TBC; Rab-GTPase-TBC domain
Nucleotide Protein Strain
Heading Accession and Version

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