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ZNF839 zinc finger protein 839 [ Homo sapiens (human) ]

Gene ID: 55778, updated on 3-Apr-2024

Summary

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Official Symbol
ZNF839provided by HGNC
Official Full Name
zinc finger protein 839provided by HGNC
Primary source
HGNC:HGNC:20345
See related
Ensembl:ENSG00000022976 AllianceGenome:HGNC:20345
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C14orf131
Summary
Predicted to enable metal ion binding activity. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 6.0), spleen (RPKM 2.7) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
14q32.31
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (102317506..102342367)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (96553100..96577964)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (102783843..102808704)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene WD repeat domain 20 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:102697452-102697952 Neighboring gene MOK protein kinase Neighboring gene MED14-independent group 3 enhancer GRCh37_chr14:102745661-102746860 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:102771382-102771904 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:102780520-102781020 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9069 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6112 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6113 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9070 Neighboring gene tRNA-Ile (anticodon AAT) 5-4 Neighboring gene small nucleolar RNA U13 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6114 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6115 Neighboring gene uncharacterized LOC124903389 Neighboring gene uncharacterized LOC124903440 Neighboring gene cyclin dependent kinase 2 interacting protein Neighboring gene tectonin beta-propeller repeat containing 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Polymorphisms in MicroRNA Binding Sites Predict Colorectal Cancer Survival. Yang YP, et al. Int J Med Sci, 2017. PMID 28138309, Free PMC Article
  2. Antigens recognized by autologous antibody in patients with renal-cell carcinoma. Scanlan MJ, et al. Int J Cancer, 1999 Nov 12. PMID 10508479
  3. Regulation of ETAA1-mediated ATR activation couples DNA replication fidelity and genome stability. Achuthankutty D, et al. J Cell Biol, 2019 Dec 2. PMID 31615875, Free PMC Article
  4. Systematic interactome mapping of acute lymphoblastic leukemia cancer gene products reveals EXT-1 tumor suppressor as a Notch1 and FBWX7 common interactor. Daakour S, et al. BMC Cancer, 2016 May 26. PMID 27229929, Free PMC Article
  5. A human MAP kinase interactome. Bandyopadhyay S, et al. Nat Methods, 2010 Oct. PMID 20936779, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZNF839 single nucleotide polymorphism association with colorectal cancer patients survival
    Title: Polymorphisms in MicroRNA Binding Sites Predict Colorectal Cancer Survival.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ11132, FLJ33514

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 839
Names
renal carcinoma antigen NY-REN-50

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001267827.2 → NP_001254756.1  zinc finger protein 839 isoform 2

    See identical proteins and their annotated locations for NP_001254756.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an exon in the 5' coding region compared to variant 1, which results in the use of a downstream translation start codon. The resulting protein (isoform 2) has a shorter N-terminus compared to isoform 1. Variants 2 and 3 both encode the same isoform (2).
    Source sequence(s)
    AL137229, AL352978
    Consensus CDS
    CCDS58336.1
    UniProtKB/Swiss-Prot
    A8K0R7, B3KSD2, Q53FH5, Q6GPI5, Q86TU1, Q9BQ86, Q9NUU3
    Related
    ENSP00000453363.1, ENST00000558850.5
    Conserved Domains (1) summary
    pfam15961
    Location:7 → 804
    DUF4764; Domain of unknown function (DUF4764)

  2. NM_001267828.2 → NP_001254757.1  zinc finger protein 839 isoform 2

    See identical proteins and their annotated locations for NP_001254757.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an exon in the 5' coding region compared to variant 1, which results in the use of a downstream translation start codon. The resulting protein (isoform 2) has a shorter N-terminus compared to isoform 1. Variants 2 and 3 both encode the same isoform (2).
    Source sequence(s)
    AL137229, AL352978
    Consensus CDS
    CCDS58336.1
    UniProtKB/Swiss-Prot
    A8K0R7, B3KSD2, Q53FH5, Q6GPI5, Q86TU1, Q9BQ86, Q9NUU3
    Related
    ENSP00000453109.1, ENST00000559185.5
    Conserved Domains (1) summary
    pfam15961
    Location:7 → 804
    DUF4764; Domain of unknown function (DUF4764)

  3. NM_001385065.1 → NP_001371994.1  zinc finger protein 839 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL137229, AL352978
    Conserved Domains (1) summary
    pfam15961
    Location:123 → 870
    DUF4764; Domain of unknown function (DUF4764)

  4. NM_001385069.1 → NP_001371998.1  zinc finger protein 839 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL137229, AL352978
    Conserved Domains (1) summary
    pfam15961
    Location:7 → 799
    DUF4764; Domain of unknown function (DUF4764)

  5. NM_001385070.1 → NP_001371999.1  zinc finger protein 839 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL137229, AL352978
    Conserved Domains (1) summary
    pfam15961
    Location:7 → 754
    DUF4764; Domain of unknown function (DUF4764)

  6. NM_001385071.1 → NP_001372000.1  zinc finger protein 839 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL137229, AL352978
    Conserved Domains (1) summary
    pfam15961
    Location:7 → 729
    DUF4764; Domain of unknown function (DUF4764)

  7. NM_001385072.1 → NP_001372001.1  zinc finger protein 839 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL137229, AL352978
    Conserved Domains (1) summary
    pfam15961
    Location:123 → 643
    DUF4764; Domain of unknown function (DUF4764)

  8. NM_001385073.1 → NP_001372002.1  zinc finger protein 839 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL137229, AL352978
    Conserved Domains (1) summary
    pfam15961
    Location:123 → 593
    DUF4764; Domain of unknown function (DUF4764)

  9. NM_001385074.1 → NP_001372003.1  zinc finger protein 839 isoform 9

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10), as well as variants 11 and 12, encodes isoform 9.
    Source sequence(s)
    AL137229, AL352978
    Conserved Domains (1) summary
    pfam15961
    Location:7 → 527
    DUF4764; Domain of unknown function (DUF4764)

  10. NM_001385075.1 → NP_001372004.1  zinc finger protein 839 isoform 9

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11), as well as variants 10 and 12, encodes isoform 9.
    Source sequence(s)
    AL137229, AL352978
    Conserved Domains (1) summary
    pfam15961
    Location:7 → 527
    DUF4764; Domain of unknown function (DUF4764)

  11. NM_001385076.1 → NP_001372005.1  zinc finger protein 839 isoform 9

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12), as well as variants 10 and 11, encodes isoform 9.
    Source sequence(s)
    AL137229, AL352978
    Conserved Domains (1) summary
    pfam15961
    Location:7 → 527
    DUF4764; Domain of unknown function (DUF4764)

  12. NM_018335.6 → NP_060805.3  zinc finger protein 839 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AL137229, AL352978
    Consensus CDS
    CCDS45164.1
    UniProtKB/Swiss-Prot
    A8K0R7
    Related
    ENSP00000399863.2, ENST00000442396.7
    Conserved Domains (1) summary
    pfam15961
    Location:123 → 920
    DUF4764; Domain of unknown function (DUF4764)

RNA

  1. NR_169565.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL137229, AL352978

  2. NR_169566.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL137229, AL352978

  3. NR_169567.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL137229, AL352978

  4. NR_169568.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL137229, AL352978

  5. NR_169569.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL137229, AL352978
    Related
    ENST00000559098.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    102317506..102342367
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011536945.2 → XP_011535247.1  zinc finger protein 839 isoform X1

    Conserved Domains (1) summary
    pfam15961
    Location:157 → 954
    DUF4764; Domain of unknown function (DUF4764)

  2. XM_011536949.4 → XP_011535251.1  zinc finger protein 839 isoform X5

    Conserved Domains (1) summary
    pfam15961
    Location:157 → 694
    DUF4764; Domain of unknown function (DUF4764)

  3. XM_011536946.4 → XP_011535248.1  zinc finger protein 839 isoform X2

    Conserved Domains (1) summary
    pfam15961
    Location:157 → 904
    DUF4764; Domain of unknown function (DUF4764)

  4. XM_011536950.4 → XP_011535252.1  zinc finger protein 839 isoform X6

    Conserved Domains (1) summary
    pfam15961
    Location:157 → 644
    DUF4764; Domain of unknown function (DUF4764)

  5. XM_006720203.4 → XP_006720266.2  zinc finger protein 839 isoform X4

  6. XM_011536948.3 → XP_011535250.2  zinc finger protein 839 isoform X3

  7. XM_017021449.3 → XP_016876938.1  zinc finger protein 839 isoform X7

    UniProtKB/TrEMBL
    H0YM06
    Related
    ENSP00000453415.1, ENST00000559155.5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    96553100..96577964
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054376370.1 → XP_054232345.1  zinc finger protein 839 isoform X1

  2. XM_054376374.1 → XP_054232349.1  zinc finger protein 839 isoform X5

  3. XM_054376371.1 → XP_054232346.1  zinc finger protein 839 isoform X2

  4. XM_054376375.1 → XP_054232350.1  zinc finger protein 839 isoform X6

  5. XM_054376373.1 → XP_054232348.1  zinc finger protein 839 isoform X4

  6. XM_054376372.1 → XP_054232347.1  zinc finger protein 839 isoform X3

  7. XM_054376376.1 → XP_054232351.1  zinc finger protein 839 isoform X7

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A8K0R7.1 GenPept UniProtKB/Swiss-Prot:A8K0R7

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