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ACTR10 actin related protein 10 [ Homo sapiens (human) ]

Gene ID: 55860, updated on 11-Apr-2024

Summary

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Official Symbol
ACTR10provided by HGNC
Official Full Name
actin related protein 10provided by HGNC
Primary source
HGNC:HGNC:17372
See related
Ensembl:ENSG00000131966 MIM:619731; AllianceGenome:HGNC:17372
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Arp10; Arp11; ACTR11; HARP11
Summary
Predicted to be involved in retrograde axonal transport of mitochondrion. Predicted to be located in cytosol; extracellular region; and secretory granule. Predicted to be part of dynactin complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 22.5), adrenal (RPKM 21.9) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
14q23.1
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (58200149..58235636)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (52407087..52442570)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (58666867..58702354)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene armadillo like helical domain containing 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5794 Neighboring gene Sharpr-MPRA regulatory region 2203 Neighboring gene ubiquitin A-52 residue ribosomal protein fusion product 1 pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8440 Neighboring gene RNA, 7SL, cytoplasmic 598, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8441 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5797 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8442 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8443 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8444 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8445 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8446 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8447 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:58711573-58712470 Neighboring gene tRNA-Lys (anticodon CTT) 1-1 Neighboring gene proteasome 20S subunit alpha 3 Neighboring gene PSMA3 antisense RNA 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Interactions between the evolutionarily conserved, actin-related protein, Arp11, actin, and Arp1. Eckley DM, et al. Mol Biol Cell, 2003 Jul. PMID 12857853, Free PMC Article
  2. Monitoring protein-protein interactions between the mammalian integral membrane transporters and PDZ-interacting partners using a modified split-ubiquitin membrane yeast two-hybrid system. Gisler SM, et al. Mol Cell Proteomics, 2008 Jul. PMID 18407958, Free PMC Article
  3. The Ciliopathy Protein CC2D2A Associates with NINL and Functions in RAB8-MICAL3-Regulated Vesicle Trafficking. Bachmann-Gagescu R, et al. PLoS Genet, 2015 Oct. PMID 26485645, Free PMC Article
  4. Insights into the ubiquitin-proteasome system of human embryonic stem cells. Saez I, et al. Sci Rep, 2018 Mar 6. PMID 29511261, Free PMC Article
  5. Mapping the Genetic Landscape of Human Cells. Horlbeck MA, et al. Cell, 2018 Aug 9. PMID 30033366, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in retrograde axonal transport of mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in axon cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in azurophil granule lumen TAS
Traceable Author Statement
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of dynactin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region TAS
Traceable Author Statement
more info
  
located_in ficolin-1-rich granule lumen TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
actin-related protein 10
Names
actin related protein 10 homolog
actin-related protein 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018477.3 → NP_060947.1  actin-related protein 10

    See identical proteins and their annotated locations for NP_060947.1

    Status: VALIDATED

    Source sequence(s)
    AF220190, AL132989, CB135721
    Consensus CDS
    CCDS32090.1
    UniProtKB/Swiss-Prot
    Q9H9Y5, Q9NWY2, Q9NZ32
    UniProtKB/TrEMBL
    B2RDG9, Q53H79
    Related
    ENSP00000254286.4, ENST00000254286.9
    Conserved Domains (1) summary
    cl17037
    Location:14 → 388
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    58200149..58235636
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011536960.2 → XP_011535262.1  actin-related protein 10 isoform X1

    UniProtKB/TrEMBL
    B2RDG9, Q53H79
    Conserved Domains (2) summary
    pfam00022
    Location:14 → 395
    Actin; Actin
    cl17037
    Location:12 → 389
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  2. XM_011536961.2 → XP_011535263.1  actin-related protein 10 isoform X2

    UniProtKB/TrEMBL
    Q53H79
    Conserved Domains (2) summary
    pfam00022
    Location:14 → 376
    Actin; Actin
    cl17037
    Location:12 → 370
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  3. XM_047431587.1 → XP_047287543.1  actin-related protein 10 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    52407087..52442570
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054376393.1 → XP_054232368.1  actin-related protein 10 isoform X1

  2. XM_054376394.1 → XP_054232369.1  actin-related protein 10 isoform X2

  3. XM_054376395.1 → XP_054232370.1  actin-related protein 10 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NZ32.1 GenPept UniProtKB/Swiss-Prot:Q9NZ32

Gene LinkOut

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