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Syt8 synaptotagmin VIII [ Mus musculus (house mouse) ]

Gene ID: 55925, updated on 2-Nov-2024

Summary

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Official Symbol
Syt8provided by MGI
Official Full Name
synaptotagmin VIIIprovided by MGI
Primary source
MGI:MGI:1859867
See related
Ensembl:ENSMUSG00000031098 AllianceGenome:MGI:1859867
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables calcium-dependent protein binding activity. Involved in acrosome reaction. Located in cytoplasm and vesicle. Is expressed in bladder. Orthologous to human SYT8 (synaptotagmin 8). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in stomach adult (RPKM 74.9), bladder adult (RPKM 52.7) and 2 other tissues See more
Orthologs
human all
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Genomic context

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See Syt8 in Genome Data Viewer
Location:
7 F5; 7 87.93 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (141988195..141994136)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (142434850..142440396)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:149567080-149567427 Neighboring gene STARR-seq mESC enhancer starr_20506 Neighboring gene cathepsin D Neighboring gene predicted gene, 26143 Neighboring gene STARR-seq mESC enhancer starr_20508 Neighboring gene troponin I, skeletal, fast 2 Neighboring gene STARR-positive B cell enhancer ABC_E10483 Neighboring gene lymphocyte specific 1 Neighboring gene proline rich 33

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Inositol 1,3,4,5-tetrakisphosphate binding activities of neuronal and non-neuronal synaptotagmins. Identification of conserved amino acid substitutions that abolish inositol 1,3,4,5-tetrakisphosphate binding to synaptotagmins III, V, and X. Ibata K, et al. J Biol Chem, 1998 May 15. PMID 9575177
  2. Calcium-dependent and -independent hetero-oligomerization in the synaptotagmin family. Fukuda M, et al. J Biochem, 2000 Oct. PMID 11011146
  3. Synaptotagmin 8 is expressed both as a calcium-insensitive soluble and membrane protein in neurons, neuroendocrine and endocrine cells. Monterrat C, et al. Biochim Biophys Acta, 2006 Jan. PMID 16386321
  4. Synaptotagmin VIII is localized to the mouse sperm head and may function in acrosomal exocytosis. Hutt DM, et al. Biol Reprod, 2002 Jan. PMID 11751263
  5. Synaptotagmin VI and VIII and syntaxin 2 are essential for the mouse sperm acrosome reaction. Hutt DM, et al. J Biol Chem, 2005 May 27. PMID 15774481

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Syt VIII is a candidate for the Ca(2+) sensor that regulates acrosomal exocytosis in mammalian sperm
    Title: Synaptotagmin VIII is localized to the mouse sperm head and may function in acrosomal exocytosis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC124104, MGC124105

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion sensor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-dependent protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables clathrin binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in acrosome reaction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in calcium-dependent activation of synaptic vesicle fusion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of calcium ion-dependent exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of synaptic vesicle exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in acrosomal vesicle IEA
Inferred from Electronic Annotation
more info
  
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in dense core granule IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in exocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in synaptic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in vesicle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
synaptotagmin-8
Names
sytVIII

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001285857.1 → NP_001272786.1  synaptotagmin-8 isoform b

    See identical proteins and their annotated locations for NP_001272786.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    AK075832
    Consensus CDS
    CCDS72071.1
    UniProtKB/TrEMBL
    F2Z3W8, Q496Q3
    Related
    ENSMUSP00000101596.2, ENSMUST00000105976.8
    Conserved Domains (1) summary
    cl14603
    Location:236 → 366
    C2; C2 domain

  2. NM_001285858.1 → NP_001272787.1  synaptotagmin-8 isoform b

    See identical proteins and their annotated locations for NP_001272787.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    AK075832
    Consensus CDS
    CCDS72071.1
    UniProtKB/TrEMBL
    F2Z3W8, Q496Q3
    Related
    ENSMUSP00000095552.3, ENSMUST00000097939.9
    Conserved Domains (1) summary
    cl14603
    Location:236 → 366
    C2; C2 domain

  3. NM_001285861.1 → NP_001272790.1  synaptotagmin-8 isoform c

    See identical proteins and their annotated locations for NP_001272790.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (c) has a longer and distinct N-terminus and lacks an alternate internal segment compared to isoform a.
    Source sequence(s)
    AK075832, AL603651
    Consensus CDS
    CCDS72070.1
    UniProtKB/Swiss-Prot
    A9JAL0, Q64366, Q8C6E7, Q9R0N6
    UniProtKB/TrEMBL
    Q496Q3
    Related
    ENSMUSP00000112689.2, ENSMUST00000122393.2
    Conserved Domains (2) summary
    cl14603
    Location:242 → 372
    C2; C2 domain
    cl25995
    Location:49 → 82
    TM_EphA1; Transmembrane domain of Ephrin Receptor A1 Protein Tyrosine Kinase

  4. NM_018802.5 → NP_061272.2  synaptotagmin-8 isoform a

    See identical proteins and their annotated locations for NP_061272.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK075832
    Consensus CDS
    CCDS22030.1
    UniProtKB/TrEMBL
    Q496Q3
    Related
    ENSMUSP00000113545.2, ENSMUST00000118276.8
    Conserved Domains (1) summary
    cl14603
    Location:242 → 372
    C2; C2 domain

RNA

  1. NR_153437.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AA023701, AL603651

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    141988195..141994136
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153263.1 → XP_036009156.1  synaptotagmin-8 isoform X6

    Conserved Domains (1) summary
    cl14603
    Location:122 → 240
    C2; C2 domain

  2. XM_036153264.1 → XP_036009157.1  synaptotagmin-8 isoform X7

    Conserved Domains (1) summary
    cl14603
    Location:122 → 240
    C2; C2 domain

  3. XM_036153265.1 → XP_036009158.1  synaptotagmin-8 isoform X8

    Conserved Domains (1) summary
    cl14603
    Location:122 → 240
    C2; C2 domain

  4. XM_006508632.5 → XP_006508695.1  synaptotagmin-8 isoform X1

    See identical proteins and their annotated locations for XP_006508695.1

    UniProtKB/TrEMBL
    Q496Q3
    Conserved Domains (1) summary
    cl14603
    Location:249 → 379
    C2; C2 domain

  5. XM_006508633.5 → XP_006508696.1  synaptotagmin-8 isoform X1

    See identical proteins and their annotated locations for XP_006508696.1

    UniProtKB/TrEMBL
    Q496Q3
    Conserved Domains (1) summary
    cl14603
    Location:249 → 379
    C2; C2 domain

  6. XM_011242014.4 → XP_011240316.1  synaptotagmin-8 isoform X2

    UniProtKB/TrEMBL
    Q496Q3
    Conserved Domains (2) summary
    cl14603
    Location:248 → 378
    C2; C2 domain
    cl25995
    Location:55 → 88
    TM_EphA1; Transmembrane domain of Ephrin Receptor A1 Protein Tyrosine Kinase

  7. XM_006508638.4 → XP_006508701.1  synaptotagmin-8 isoform X3

    See identical proteins and their annotated locations for XP_006508701.1

    UniProtKB/TrEMBL
    Q496Q3
    Conserved Domains (2) summary
    cl14603
    Location:243 → 373
    C2; C2 domain
    cl25995
    Location:50 → 83
    TM_EphA1; Transmembrane domain of Ephrin Receptor A1 Protein Tyrosine Kinase

  8. XM_006508639.4 → XP_006508702.1  synaptotagmin-8 isoform X3

    See identical proteins and their annotated locations for XP_006508702.1

    UniProtKB/TrEMBL
    Q496Q3
    Conserved Domains (2) summary
    cl14603
    Location:243 → 373
    C2; C2 domain
    cl25995
    Location:50 → 83
    TM_EphA1; Transmembrane domain of Ephrin Receptor A1 Protein Tyrosine Kinase

  9. XM_011242015.4 → XP_011240317.1  synaptotagmin-8 isoform X3

    See identical proteins and their annotated locations for XP_011240317.1

    UniProtKB/TrEMBL
    Q496Q3
    Conserved Domains (2) summary
    cl14603
    Location:243 → 373
    C2; C2 domain
    cl25995
    Location:50 → 83
    TM_EphA1; Transmembrane domain of Ephrin Receptor A1 Protein Tyrosine Kinase

  10. XM_006508635.5 → XP_006508698.1  synaptotagmin-8 isoform X3

    See identical proteins and their annotated locations for XP_006508698.1

    UniProtKB/TrEMBL
    Q496Q3
    Conserved Domains (2) summary
    cl14603
    Location:243 → 373
    C2; C2 domain
    cl25995
    Location:50 → 83
    TM_EphA1; Transmembrane domain of Ephrin Receptor A1 Protein Tyrosine Kinase

  11. XM_006508637.5 → XP_006508700.1  synaptotagmin-8 isoform X3

    See identical proteins and their annotated locations for XP_006508700.1

    UniProtKB/TrEMBL
    Q496Q3
    Conserved Domains (2) summary
    cl14603
    Location:243 → 373
    C2; C2 domain
    cl25995
    Location:50 → 83
    TM_EphA1; Transmembrane domain of Ephrin Receptor A1 Protein Tyrosine Kinase

  12. XM_036153262.1 → XP_036009155.1  synaptotagmin-8 isoform X5

    UniProtKB/TrEMBL
    Q496Q4
    Conserved Domains (1) summary
    cl14603
    Location:138 → 268
    C2; C2 domain

  13. XM_011242016.4 → XP_011240318.1  synaptotagmin-8 isoform X4

    See identical proteins and their annotated locations for XP_011240318.1

    UniProtKB/Swiss-Prot
    A9JAL0, Q64366, Q8C6E7, Q9R0N6
    UniProtKB/TrEMBL
    Q496Q3
    Conserved Domains (2) summary
    cl14603
    Location:242 → 372
    C2; C2 domain
    cl25995
    Location:49 → 82
    TM_EphA1; Transmembrane domain of Ephrin Receptor A1 Protein Tyrosine Kinase

  14. XM_036153261.1 → XP_036009154.1  synaptotagmin-8 isoform X1

    UniProtKB/TrEMBL
    Q496Q3
    Conserved Domains (1) summary
    cl14603
    Location:249 → 379
    C2; C2 domain

RNA

  1. XR_004934155.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9R0N6.1 GenPept UniProtKB/Swiss-Prot:Q9R0N6

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