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Stx8 syntaxin 8 [ Mus musculus (house mouse) ]

Gene ID: 55943, updated on 2-Nov-2024

Summary

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Official Symbol
Stx8provided by MGI
Official Full Name
syntaxin 8provided by MGI
Primary source
MGI:MGI:1890156
See related
Ensembl:ENSMUSG00000020903 AllianceGenome:MGI:1890156
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CARB; 0610007H08Rik; 1110002H11Rik; 4930571E13Rik
Summary
Enables ubiquitin protein ligase binding activity. Acts upstream of or within cellular response to type II interferon. Located in phagocytic vesicle. Is active in late endosome. Orthologous to human STX8 (syntaxin 8). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in bladder adult (RPKM 3.4), testis adult (RPKM 2.7) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Stx8 in Genome Data Viewer
Location:
11 B3; 11 41.2 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (67857237..68097974)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (67966411..68207148)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 43 Neighboring gene cilia and flagella associated protein 52 Neighboring gene STARR-seq mESC enhancer starr_29808 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:67939507-67939823 Neighboring gene ribosomal protein L31 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:68012718-68012928 Neighboring gene expressed sequence C78197 Neighboring gene microRNA 6406 Neighboring gene netrin 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:68084195-68084304 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:68084370-68084566 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:68084658-68084931 Neighboring gene STARR-seq mESC enhancer starr_29815 Neighboring gene STARR-seq mESC enhancer starr_29816 Neighboring gene predicted gene, 31954

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Syntaxin 8 regulates platelet dense granule secretion, aggregation, and thrombus stability. Golebiewska EM, et al. J Biol Chem, 2015 Jan 16. PMID 25404741, Free PMC Article
  2. The two-pore channel TPC1 is required for efficient protein processing through early and recycling endosomes. Castonguay J, et al. Sci Rep, 2017 Aug 30. PMID 28855648, Free PMC Article
  3. Interaction between syntaxin 8 and HECTd3, a HECT domain ligase. Zhang L, et al. Cell Mol Neurobiol, 2009 Feb. PMID 18821010
  4. BLOC-1 complex deficiency alters the targeting of adaptor protein complex-3 cargoes. Salazar G, et al. Mol Biol Cell, 2006 Sep. PMID 16760431, Free PMC Article
  5. Dry ice is a reliable substrate for the distribution of frozen mouse spermatozoa: A multi-centric study. Raspa M, et al. Theriogenology, 2017 Jul 1. PMID 28532839

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Syntaxin 8 has a role in regulating platelet dense granule secretion, aggregation, and thrombus stability
    Title: Syntaxin 8 regulates platelet dense granule secretion, aggregation, and thrombus stability.
  2. Syntaxin 8 and HECTd3 have similar subcellular localization.
    Title: Interaction between syntaxin 8 and HECTd3, a HECT domain ligase.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SNAP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SNARE binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables chloride channel inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables chloride channel inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables syntaxin binding IEA
Inferred from Electronic Annotation
more info
  
enables syntaxin binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to type II interferon IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in early endosome to late endosome transport IEA
Inferred from Electronic Annotation
more info
  
involved_in early endosome to late endosome transport ISO
Inferred from Sequence Orthology
more info
  
involved_in endosome to lysosome transport ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of protein localization to plasma membrane IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in vesicle docking IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle fusion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle fusion ISO
Inferred from Sequence Orthology
more info
  
involved_in vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SNARE complex ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome IEA
Inferred from Electronic Annotation
more info
  
located_in early endosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in late endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in late endosome ISO
Inferred from Sequence Orthology
more info
  
located_in late endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in phagocytic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in recycling endosome IEA
Inferred from Electronic Annotation
more info
  
located_in recycling endosome ISO
Inferred from Sequence Orthology
more info
  
located_in trans-Golgi network IEA
Inferred from Electronic Annotation
more info
  
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
  
located_in vesicle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
syntaxin-8
Names
syntaxin-like protein 3I35

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356314.1 → NP_001343243.1  syntaxin-8 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks several exons and includes an alternate 3' terminal exon, compared to variant 1. It encodes isoform 2, which is shorter and has a novel C-terminus, compared to isoform 1.
    Source sequence(s)
    AK003297, AK011376, AL663076
    Consensus CDS
    CCDS88173.1
    UniProtKB/TrEMBL
    Q9D0J1
    Related
    ENSMUSP00000021286.5, ENSMUST00000021286.11

  2. NM_001361350.1 → NP_001348279.1  syntaxin-8 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL663076, AL669842
    Conserved Domains (1) summary
    cd15852
    Location:41 → 95
    SNARE_Syntaxin8; SNARE motif of syntaxin 8

  3. NM_001361351.1 → NP_001348280.1  syntaxin-8 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AK003297, AK018716, BC048167
    Conserved Domains (1) summary
    cd15852
    Location:41 → 95
    SNARE_Syntaxin8; SNARE motif of syntaxin 8

  4. NM_001361352.1 → NP_001348281.1  syntaxin-8 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AK003297, AK035105, AL663076, BE984450
    Consensus CDS
    CCDS88174.1
    UniProtKB/TrEMBL
    Q8BS59
    Related
    ENSMUSP00000104315.2, ENSMUST00000108675.2

  5. NM_018768.3 → NP_061238.1  syntaxin-8 isoform 1

    See identical proteins and their annotated locations for NP_061238.1

    Status: VALIDATED

    Source sequence(s)
    AK003297, BC048167
    Consensus CDS
    CCDS24863.1
    UniProtKB/Swiss-Prot
    O88983
    Related
    ENSMUSP00000021285.8, ENSMUST00000021285.14
    Conserved Domains (1) summary
    cd15852
    Location:152 → 206
    SNARE_Syntaxin8; SNARE motif of syntaxin 8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    67857237..68097974
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030246161.1 → XP_030102021.1  syntaxin-8 isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O88983.1 GenPept UniProtKB/Swiss-Prot:O88983

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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