U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

NXF2 nuclear RNA export factor 2 [ Homo sapiens (human) ]

Gene ID: 56001, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
NXF2provided by HGNC
Official Full Name
nuclear RNA export factor 2provided by HGNC
Primary source
HGNC:HGNC:8072
See related
Ensembl:ENSG00000269405 MIM:300315; AllianceGenome:HGNC:8072
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT39; TAPL-2; TCP11X2
Summary
This gene encodes a member of a family of nuclear RNA export proteins. The encoded protein is associated with the nuclear envelope and aids in the export of mRNAs. There is a closely related paralog of this gene located adjacent on chromosome X and on the opposite strand. [provided by RefSeq, Aug 2013]
Expression
Restricted expression toward testis (RPKM 10.2) See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See NXF2 in Genome Data Viewer
Location:
Xq22.1
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (102247167..102326722)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (100691761..100771287)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (101502161..101581636)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene t-complex 11 family, X-linked 3, pseudogene Neighboring gene t-complex 11 family, X-linked 1 Neighboring gene leucine rich repeat containing 14 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20918 Neighboring gene nuclear RNA export factor 2B Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:101726202-101726702 Neighboring gene t-complex 11 family, X-linked 2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Is there a role for the nuclear export factor 2 gene in male infertility? Stouffs K, et al. Fertil Steril, 2008 Nov. PMID 18258234
  2. The cancer‑testis antigen NXF2 is activated by the hypomethylating agent decitabine in acute leukemia cells in vitro and in vivo. Zhou J, et al. Mol Med Rep, 2013 Nov. PMID 24002123
  3. De novo duplication of Xq22.1→q24 with a disruption of the NXF gene cluster in a mentally retarded woman with short stature and premature ovarian failure. Chen CP, et al. Taiwan J Obstet Gynecol, 2011 Sep. PMID 22030050
  4. Chromosome X-encoded cancer/testis antigens show distinctive expression patterns in developing gonads and in testicular seminoma. Chen YT, et al. Hum Reprod, 2011 Dec. PMID 22016418
  5. Treatment of chronic lymphocytic leukemia with a hypomethylating agent induces expression of NXF2, an immunogenic cancer testis antigen. Dubovsky JA, et al. Clin Cancer Res, 2009 May 15. PMID 19401350

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Low NXF2 expression is associated with leukemia.
    Title: The cancer‑testis antigen NXF2 is activated by the hypomethylating agent decitabine in acute leukemia cells in vitro and in vivo.
  2. Data do not support role for NXF2 in male infertility.
    Title: Is there a role for the nuclear export factor 2 gene in male infertility?
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • FLJ20416

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mRNA export from nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mRNA export from nucleus NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in poly(A)+ mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of nuclear RNA export factor complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of nuclear RNA export factor complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of nuclear RNA export factor complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

Go to the top of the page Help
Preferred Names
nuclear RNA export factor 2
Names
TAP-like protein 2
cancer/testis antigen 39
t-complex protein 11 homolog

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022053.4 → NP_071336.1  nuclear RNA export factor 2

    See identical proteins and their annotated locations for NP_071336.1

    Status: REVIEWED

    Source sequence(s)
    AC234791
    Consensus CDS
    CCDS14497.1
    UniProtKB/Swiss-Prot
    Q9BXU4, Q9GZY0, Q9NSS1, Q9NX66
    Related
    ENSP00000485586.2, ENST00000625106.4
    Conserved Domains (5) summary
    smart00804
    Location:570 → 623
    TAP_C; C-terminal domain of vertebrate Tap protein
    sd00035
    Location:229 → 271
    LRR_NTF; leucine-rich repeat [structural motif]
    pfam09162
    Location:121 → 203
    Tap-RNA_bind; Tap, RNA-binding
    pfam13855
    Location:270 → 332
    LRR_8; Leucine rich repeat
    cl09109
    Location:391 → 543
    NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    102247167..102326722
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    100691761..100771287
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001039910.1: Suppressed sequence

    Description
    NM_001039910.1: This RefSeq was suppressed because it is thought to represent 5' UTR rather than a distinct protein coding region.

  2. NM_017809.3: Suppressed sequence

    Description
    NM_017809.3: This RefSeq was permanently suppressed because it is now thought that this transcript does encode a protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9GZY0.1 GenPept UniProtKB/Swiss-Prot:Q9GZY0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous