U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Il17b interleukin 17B [ Mus musculus (house mouse) ]

Gene ID: 56069, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Il17bprovided by MGI
Official Full Name
interleukin 17Bprovided by MGI
Primary source
MGI:MGI:1928397
See related
Ensembl:ENSMUSG00000024578 AllianceGenome:MGI:1928397
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Zcyto7; 1110006O16Rik; 1700006N07Rik
Summary
Enables cytokine activity. Acts upstream of or within positive regulation of cytokine production involved in inflammatory response. Predicted to be located in extracellular space. Is expressed in several structures, including central nervous system; dorsal root ganglion; limb; limb bud; and trunk. Orthologous to human IL17B (interleukin 17B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in limb E14.5 (RPKM 8.8), mammary gland adult (RPKM 3.7) and 1 other tissue See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Il17b in Genome Data Viewer
Location:
18 E1; 18 34.67 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (61821006..61825609)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (61687935..61692538)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene microRNA 145a Neighboring gene cardiac mesoderm enhancer-associated non-coding RNA Neighboring gene microRNA 143 Neighboring gene predicted gene, 38165 Neighboring gene STARR-positive B cell enhancer mm9_chr18:61857809-61858110 Neighboring gene prenylcysteine oxidase 1 like Neighboring gene STARR-seq mESC enhancer starr_44762 Neighboring gene GrpE-like 2, mitochondrial Neighboring gene predicted gene, 17883

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Interleukin 17 B regulates colonic myeloid cell infiltration in a mouse model of DSS-induced colitis. Zhang X, et al. Front Immunol, 2023. PMID 36814913, Free PMC Article
  2. Necroptosis Plays a Crucial Role in Vascular Injury during DVT and Is Enhanced by IL-17B. Li Y, et al. J Immunol Res, 2022. PMID 36046722, Free PMC Article
  3. Expression of interleukin-17B in mouse embryonic limb buds and regulation by BMP-7 and bFGF. You Z, et al. Biochem Biophys Res Commun, 2005 Jan 21. PMID 15596145
  4. IL-17B alleviates the pathogenesis of systemic lupus erythematosus by inhibiting FASN-mediated differentiation of B cells. Xiao Y, et al. JCI Insight, 2024 Aug 8. PMID 39115936, Free PMC Article
  5. Expression of IL-17B in neurons and evaluation of its possible role in the chromosome 5q-linked form of Charcot-Marie-Tooth disease. Moore EE, et al. Neuromuscul Disord, 2002 Feb. PMID 11738356

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. IL-17B alleviates the pathogenesis of systemic lupus erythematosus by inhibiting FASN-mediated differentiation of B cells.
    Title: IL-17B alleviates the pathogenesis of systemic lupus erythematosus by inhibiting FASN-mediated differentiation of B cells.
  2. Necroptosis Plays a Crucial Role in Vascular Injury during DVT and Is Enhanced by IL-17B.
    Title: Necroptosis Plays a Crucial Role in Vascular Injury during DVT and Is Enhanced by IL-17B.
  3. Interleukin-17B antagonizes interleukin-25-mediated mucosal inflammation.
    Title: Interleukin-17B Antagonizes Interleukin-25-Mediated Mucosal Inflammation.
  4. Results show that amplified signaling of interleukin-17 receptor B (IL-17RB) and its ligand IL-17B promot tumorigenicity in breast cancer cells and impeded acinus formation in immortalized normal mammary epithelial cells.
    Title: Autocrine/paracrine mechanism of interleukin-17B receptor promotes breast tumorigenesis through NF-κB-mediated antiapoptotic pathway.
  5. IL-17B and IL-17C play an important role in the pathogenesis of inflammatory arthritis.
    Title: IL-17B and IL-17C are associated with TNF-alpha production and contribute to the exacerbation of inflammatory arthritis.
  6. expressed in the mouse embryonic limb buds and may play a role in chondrogenesis and osteogenesis
    Title: Expression of interleukin-17B in mouse embryonic limb buds and regulation by BMP-7 and bFGF.
  7. Socs3 is an essential negative regulator of IL-23 signaling, inhibition of which constrains the generation of IL-17-secreting T-cell differentiation
    Title: Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
Process Evidence Code Pubs
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within neutrophil chemotaxis ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within positive regulation of cytokine production involved in inflammatory response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
interleukin-17B
Names
IL-17B
cytokine CX1
cytokine-like protein ZCYTO7
gene for cytokine-like protein
neuronal interleukin-17-related factor

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019508.1 → NP_062381.1  interleukin-17B precursor

    See identical proteins and their annotated locations for NP_062381.1

    Status: PROVISIONAL

    Source sequence(s)
    AF184970
    Consensus CDS
    CCDS29286.1
    UniProtKB/Swiss-Prot
    Q99MY3, Q9CTI4, Q9QXT6
    Related
    ENSMUSP00000025471.3, ENSMUST00000025471.4
    Conserved Domains (1) summary
    pfam06083
    Location:96 → 179
    IL17; Interleukin-17

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    61821006..61825609
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250543.2 → XP_030106403.1  interleukin-17B isoform X2

    Conserved Domains (1) summary
    pfam06083
    Location:41 → 120
    IL17; Interleukin-17

  2. XM_006526106.4 → XP_006526169.1  interleukin-17B isoform X1

    Conserved Domains (1) summary
    pfam06083
    Location:101 → 180
    IL17; Interleukin-17

  3. XM_006526108.5 → XP_006526171.1  interleukin-17B isoform X2

    See identical proteins and their annotated locations for XP_006526171.1

    Conserved Domains (1) summary
    pfam06083
    Location:41 → 120
    IL17; Interleukin-17
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QXT6.1 GenPept UniProtKB/Swiss-Prot:Q9QXT6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools