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Tcerg1 transcription elongation regulator 1 (CA150) [ Mus musculus (house mouse) ]

Gene ID: 56070, updated on 17-Aug-2024

Summary

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Official Symbol
Tcerg1provided by MGI
Official Full Name
transcription elongation regulator 1 (CA150)provided by MGI
Primary source
MGI:MGI:1926421
See related
Ensembl:ENSMUSG00000024498 AllianceGenome:MGI:1926421
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p144; FBP23; FBP28; Taf2s; ca150; CA150b; 2410022J09Rik; 2900090C16Rik
Summary
Enables proline-rich region binding activity. Predicted to be involved in RNA processing and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within transcription, DNA-templated. Predicted to be located in nuclear matrix and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including branchial arch; limb bud; liver; metanephros; and pancreas epithelium. Orthologous to human TCERG1 (transcription elongation regulator 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 20.3), CNS E14 (RPKM 15.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Tcerg1 in Genome Data Viewer
Location:
18 B3; 18 22.66 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (42644369..42708850)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (42511304..42575785)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31501 Neighboring gene STARR-seq mESC enhancer starr_44441 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:42670844-42671027 Neighboring gene STARR-seq mESC enhancer starr_44443 Neighboring gene STARR-positive B cell enhancer mm9_chr18:42717560-42717861 Neighboring gene STARR-positive B cell enhancer ABC_E400 Neighboring gene G protein-coupled receptor 151 Neighboring gene RIKEN cDNA C030004G16 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The ensemble folding kinetics of the FBP28 WW domain revealed by an all-atom Monte Carlo simulation in a knowledge-based potential. Xu J, et al. Proteins, 2011 Jun. PMID 21365688, Free PMC Article
  2. Phi-analysis at the experimental limits: mechanism of beta-hairpin formation. Petrovich M, et al. J Mol Biol, 2006 Jul 21. PMID 16784750
  3. Structural analysis of WW domains and design of a WW prototype. Macias MJ, et al. Nat Struct Biol, 2000 May. PMID 10802733
  4. Molecular cloning and splicing isoforms of mouse p144, a homologue of CA150. Shimada M, et al. J Biochem, 1999 Dec. PMID 10578054
  5. Identification of a co-repressor that inhibits the transcriptional and growth-arrest activities of CCAAT/enhancer-binding protein alpha. McFie PJ, et al. J Biol Chem, 2006 Jun 30. PMID 16644732

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The study examines the order of formation of two beta-hairpins, the folding mechanism of each individual beta-hairpin, and transition state ensemble of formin-binding protein 28, FBP28 WW domain.
    Title: The ensemble folding kinetics of the FBP28 WW domain revealed by an all-atom Monte Carlo simulation in a knowledge-based potential.
  2. The first beta-turn is near native-like in the transition state for folding and unfolding. Only after the backbone hydrogen bonds are formed between beta1 and beta2 does a hydrogen bond form to stabilize the first beta-turn.
    Title: Phi-analysis at the experimental limits: mechanism of beta-hairpin formation.
  3. CA150 FF domains recognize multiple sites within the Tat-SF1 protein conforming to the consensus motif (D/E)(2/5)-F/W/Y-(D/E)(2/5).
    Title: FF domains of CA150 bind transcription and splicing factors through multiple weak interactions.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables proline-rich region binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-like protein conjugating enzyme binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in RNA splicing ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA processing ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nuclear matrix ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
transcription elongation regulator 1
Names
TATA box binding protein (TBP)-associated factor, RNA polymerase II, S, 150kD
TATA box-binding protein-associated factor 2S
coactivator of 150 kD
formin-binding protein 28
transcription factor CA150
transcription factor CA150b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039474.1 → NP_001034563.1  transcription elongation regulator 1 isoform 1

    See identical proteins and their annotated locations for NP_001034563.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK082750, AK168434, CJ052824
    Consensus CDS
    CCDS29214.1
    UniProtKB/Swiss-Prot
    Q61051, Q8C490, Q8CGF7, Q8CHT8, Q9R0R5
    UniProtKB/TrEMBL
    Q3TH57
    Related
    ENSMUSP00000158288.2, ENSMUST00000237602.2
    Conserved Domains (4) summary
    smart00441
    Location:957 → 1012
    FF; Contains two conserved F residues
    smart00456
    Location:132 → 164
    WW; Domain with 2 conserved Trp (W) residues
    cd00201
    Location:435 → 464
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam01846
    Location:796 → 845
    FF; FF domain

  2. NM_001289526.1 → NP_001276455.1  transcription elongation regulator 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region and contains an alternate 3' exon, compared to variant 1. This results in a shorter isoform (2), compared to isoform 1.
    Source sequence(s)
    AC121603, AK076993, AK082750, AK150312, CJ052824
    UniProtKB/Swiss-Prot
    Q8CGF7
    Conserved Domains (4) summary
    smart00441
    Location:953 → 1008
    FF; Contains two conserved F residues
    smart00456
    Location:132 → 164
    WW; Domain with 2 conserved Trp (W) residues
    cd00201
    Location:414 → 443
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam01846
    Location:792 → 841
    FF; FF domain

  3. NM_001360881.1 → NP_001347810.1  transcription elongation regulator 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter isoform (3), compared to isoform 1.
    Source sequence(s)
    AC121603
    Consensus CDS
    CCDS89230.1
    Related
    ENSMUSP00000025375.9, ENSMUST00000025375.15
    Conserved Domains (4) summary
    smart00441
    Location:994 → 1058
    FF; Contains two conserved F residues
    smart00456
    Location:132 → 164
    WW; Domain with 2 conserved Trp (W) residues
    cl00157
    Location:402 → 999
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cl25496
    Location:258 → 346
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

RNA

  1. NR_110344.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate 3' exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC121603, AK082750, AK168434, CJ052824

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    42644369..42708850
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526111.4 → XP_006526174.1  transcription elongation regulator 1 isoform X2

    Conserved Domains (4) summary
    smart00441
    Location:1032 → 1096
    FF; Contains two conserved F residues
    smart00456
    Location:132 → 164
    WW; Domain with 2 conserved Trp (W) residues
    COG5104
    Location:423 → 1037
    PRP40; Splicing factor [RNA processing and modification]
    pfam03154
    Location:258 → 418
    Atrophin-1; Atrophin-1 family

  2. XM_006526110.4 → XP_006526173.1  transcription elongation regulator 1 isoform X1

    Conserved Domains (4) summary
    smart00441
    Location:1038 → 1102
    FF; Contains two conserved F residues
    smart00456
    Location:132 → 164
    WW; Domain with 2 conserved Trp (W) residues
    COG5104
    Location:429 → 1043
    PRP40; Splicing factor [RNA processing and modification]
    pfam05109
    Location:258 → 352
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

  3. XM_006526112.5 → XP_006526175.1  transcription elongation regulator 1 isoform X3

    Conserved Domains (4) summary
    smart00441
    Location:1021 → 1085
    FF; Contains two conserved F residues
    smart00456
    Location:132 → 164
    WW; Domain with 2 conserved Trp (W) residues
    COG5104
    Location:429 → 1026
    PRP40; Splicing factor [RNA processing and modification]
    pfam05109
    Location:258 → 352
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

  4. XM_006526113.4 → XP_006526176.1  transcription elongation regulator 1 isoform X4

    Conserved Domains (4) summary
    smart00441
    Location:1017 → 1081
    FF; Contains two conserved F residues
    smart00456
    Location:132 → 164
    WW; Domain with 2 conserved Trp (W) residues
    COG5104
    Location:408 → 1022
    PRP40; Splicing factor [RNA processing and modification]
    pfam03154
    Location:258 → 403
    Atrophin-1; Atrophin-1 family

  5. XM_030250545.2 → XP_030106405.1  transcription elongation regulator 1 isoform X5

    Conserved Domains (4) summary
    smart00441
    Location:1000 → 1064
    FF; Contains two conserved F residues
    smart00456
    Location:132 → 164
    WW; Domain with 2 conserved Trp (W) residues
    COG5104
    Location:408 → 1005
    PRP40; Splicing factor [RNA processing and modification]
    pfam03154
    Location:258 → 403
    Atrophin-1; Atrophin-1 family

RNA

  1. XR_004939874.1 RNA Sequence

  2. XR_001782385.3 RNA Sequence

  3. XR_001782384.3 RNA Sequence

  4. XR_004939873.1 RNA Sequence

  5. XR_386004.5 RNA Sequence

  6. XR_001782386.3 RNA Sequence

  7. XR_001782383.3 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_019512.1: Suppressed sequence

    Description
    NM_019512.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CGF7.2 GenPept UniProtKB/Swiss-Prot:Q8CGF7

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