U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Scaf1 SR-related CTD-associated factor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 56081, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Scaf1provided by RGD
Official Full Name
SR-related CTD-associated factor 1provided by RGD
Primary source
RGD:708405
See related
EnsemblRapid:ENSRNOG00000056946 AllianceGenome:RGD:708405
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Sr-a1
Summary
Enables protein domain specific binding activity. Involved in mRNA processing and transcription by RNA polymerase II. Predicted to be located in nucleus. Biomarker of end stage renal disease. Orthologous to human SCAF1 (SR-related CTD associated factor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 56.5), Kidney (RPKM 46.4) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Scaf1 in Genome Data Viewer
Location:
1q22
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (104621927..104635161, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (95485448..95499389, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (100997724..101010855, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene protein arginine methyltransferase 1 Neighboring gene Bcl2 like 12 Neighboring gene interferon regulatory factor 3 Neighboring gene RAS related Neighboring gene proline rich 12

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Expression of the C-terminal domain of novel human SR-A1 protein: interaction with the CTD domain of RNA polymerase II. Katsarou ME, et al. Biochem Biophys Res Commun, 2005 Aug 19. PMID 15992770
  2. The C-terminal domain of the largest subunit of RNA polymerase II interacts with a novel set of serine/arginine-rich proteins. Yuryev A, et al. Proc Natl Acad Sci U S A, 1996 Jul 9. PMID 8692929, Free PMC Article
  3. Niacin improves renal lipid metabolism and slows progression in chronic kidney disease. Cho KH, et al. Biochim Biophys Acta, 2010 Jan. PMID 19878707
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II C-terminal domain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II C-terminal domain binding ISO
Inferred from Sequence Orthology
more info
  
enables protein domain specific binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
splicing factor, arginine/serine-rich 19
Names
CTD-binding SR-like protein rA1
CTD-binding SR-like rA1
SR-related and CTD-associated factor 1
serine arginine-rich pre-mRNA splicing factor SR-A1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001400823.1 → NP_001387752.1  splicing factor, arginine/serine-rich 19

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    Q63624

  2. NM_001414200.1 → NP_001401129.1  splicing factor, arginine/serine-rich 19

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    Q63624
    Related
    ENSRNOP00000072566.1, ENSRNOT00000081430.3

  3. NM_019384.2 → NP_062257.2  splicing factor, arginine/serine-rich 19

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    Q63624

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    104621927..104635161 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063272028.1 → XP_063128098.1  splicing factor, arginine/serine-rich 19 isoform X2

  2. XM_039088703.2 → XP_038944631.2  splicing factor, arginine/serine-rich 19 isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q63624.2 GenPept UniProtKB/Swiss-Prot:Q63624

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools