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TEX11 testis expressed 11 [ Homo sapiens (human) ]

Gene ID: 56159, updated on 5-Mar-2024

Summary

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Official Symbol
TEX11provided by HGNC
Official Full Name
testis expressed 11provided by HGNC
Primary source
HGNC:HGNC:11733
See related
Ensembl:ENSG00000120498 MIM:300311; AllianceGenome:HGNC:11733
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TGC1; ZIP4; MZIP4; Spo22; TSGA3; ZIP4H; SPGFX2
Summary
This gene is X-linked and is expressed in only male germ cells. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Biased expression in pancreas (RPKM 5.2), testis (RPKM 5.1) and 1 other tissue See more
Orthologs
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Genomic context

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See TEX11 in Genome Data Viewer
Location:
Xq13.1
Exon count:
36
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (70511227..70908711, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (68944548..69342011, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (69748790..70128561, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20891 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:69674628-69675054 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20893 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chrX:69696945-69697843 Neighboring gene RNA, U4 small nuclear 81, pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chrX:69699902-69700403 Neighboring gene DLG3 antisense RNA 1 Neighboring gene discs large MAGUK scaffold protein 3 Neighboring gene NANOG hESC enhancer GRCh37_chrX:69728146-69728708 Neighboring gene small integral membrane protein 30-like Neighboring gene small nucleolar RNA, C/D box 3E Neighboring gene WASHC3 pseudogene 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:70150189-70150690 Neighboring gene solute carrier family 7 member 3 Neighboring gene ribosomal protein S23 pseudogene 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Novel mutations of TEX11 are associated with non-obstructive azoospermia. Song J, et al. Front Endocrinol (Lausanne), 2023. PMID 37124723, Free PMC Article
  2. Testis-expressed gene 11 inhibits cisplatin-induced DNA damage and contributes to chemoresistance in testicular germ cell tumor. Kitayama S, et al. Sci Rep, 2022 Nov 1. PMID 36319719, Free PMC Article
  3. Downregulation of TEX11 promotes S-Phase progression and proliferation in colorectal cancer cells through the FOXO3a/COP1/c-Jun/p21 axis. Zhang X, et al. Oncogene, 2022 Nov. PMID 36258021
  4. Zinc transporter mutations linked to acrodermatitis enteropathica disrupt function and cause mistrafficking. Kuliyev E, et al. J Biol Chem, 2021 Jan-Jun. PMID 33837739, Free PMC Article
  5. A new TEX11 mutation causes azoospermia and testicular meiotic arrest. Yu XC, et al. Asian J Androl, 2021 Sep-Oct. PMID 33762476, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Novel mutations of TEX11 are associated with non-obstructive azoospermia.
    Title: Novel mutations of TEX11 are associated with non-obstructive azoospermia.
  2. Downregulation of TEX11 promotes S-Phase progression and proliferation in colorectal cancer cells through the FOXO3a/COP1/c-Jun/p21 axis.
    Title: Downregulation of TEX11 promotes S-Phase progression and proliferation in colorectal cancer cells through the FOXO3a/COP1/c-Jun/p21 axis.
  3. Testis-expressed gene 11 inhibits cisplatin-induced DNA damage and contributes to chemoresistance in testicular germ cell tumor.
    Title: Testis-expressed gene 11 inhibits cisplatin-induced DNA damage and contributes to chemoresistance in testicular germ cell tumor.
  4. Association of CATSPER1, SPATA16 and TEX11 genes polymorphism with idiopathic azoospermia and oligospermia risk in Iranian population.
    Title: Association of CATSPER1, SPATA16 and TEX11 genes polymorphism with idiopathic azoospermia and oligospermia risk in Iranian population.
  5. Targeted next-generation sequencing panel screening of 668 Chinese patients with non-obstructive azoospermia.
    Title: Targeted next-generation sequencing panel screening of 668 Chinese patients with non-obstructive azoospermia.
  6. A new TEX11 mutation causes azoospermia and testicular meiotic arrest.
    Title: A new TEX11 mutation causes azoospermia and testicular meiotic arrest.
  7. Zinc transporter mutations linked to acrodermatitis enteropathica disrupt function and cause mistrafficking.
    Title: Zinc transporter mutations linked to acrodermatitis enteropathica disrupt function and cause mistrafficking.
  8. This result suggests that regular expression of TEX11, TEX12, TEX14 and TEX15 is essential for the early stages of spermatogenesis.
    Title: Expression analysis of genes encoding TEX11, TEX12, TEX14 and TEX15 in testis tissues of men with non-obstructive azoospermia.
  9. Data identified one novel TEX11 mutation in two brothers. The missense mutation is associated with male infertility, especially azoospermia.
    Title: A novel TEX11 mutation induces azoospermia: a case report of infertile brothers and literature review.
  10. Through the translational regulation of novel RNA targets SMC1B and TEX11, DAZL may have a key role in regulating chromosome cohesion and DNA recombination; two processes fundamental in determining oocyte quality and whose establishment in foetal life may support lifelong fertility.
    Title: RNA immunoprecipitation identifies novel targets of DAZL in human foetal ovary.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Spermatogenic failure, X-linked, 2
MedGen: C1839841 OMIM: 309120 GeneReviews: Not available
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Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in chiasma assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in ectopic germ cell programmed cell death IEA
Inferred from Electronic Annotation
more info
  
involved_in fertilization IEA
Inferred from Electronic Annotation
more info
  
involved_in male gonad development IEA
Inferred from Electronic Annotation
more info
  
involved_in male meiosis chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in meiotic gene conversion ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of developmental process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of reproductive process IEA
Inferred from Electronic Annotation
more info
  
involved_in reciprocal meiotic recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in reciprocal meiotic recombination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in resolution of meiotic recombination intermediates IEA
Inferred from Electronic Annotation
more info
  
involved_in synaptonemal complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in central element IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromosome ISS
Inferred from Sequence or Structural Similarity
more info
  
colocalizes_with synaptonemal complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
testis-expressed protein 11
Names
ZIP4 homolog
protein ZIP4 homolog
testis expressed sequence 11
testis-expressed sequence 11 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012574.3 RefSeqGene

    Range
    5000..384771
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001003811.2 → NP_001003811.1  testis-expressed protein 11 isoform 1

    See identical proteins and their annotated locations for NP_001003811.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK057523, BC036016, BG219070, BU929507
    Consensus CDS
    CCDS35323.1
    UniProtKB/Swiss-Prot
    A8K8V6, Q5JQQ8, Q8IYF3, Q96LZ4, Q96M47, Q9BXU6
    Related
    ENSP00000379226.2, ENST00000395889.6
    Conserved Domains (2) summary
    sd00006
    Location:417 → 451
    TPR; TPR repeat [structural motif]
    pfam08631
    Location:190 → 444
    SPO22; Meiosis protein SPO22/ZIP4 like

  2. NM_031276.3 → NP_112566.2  testis-expressed protein 11 isoform 2

    See identical proteins and their annotated locations for NP_112566.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' region, as compared to variant 1. It uses an upstream in-frame AUG codon and encodes isoform 2 which has a shorter and distinct N-terminus, as compared to isoform 1.
    Source sequence(s)
    AK057391, AK057523, BC036016, BG219070, BU929507
    Consensus CDS
    CCDS43968.1
    UniProtKB/Swiss-Prot
    Q8IYF3
    Related
    ENSP00000363453.2, ENST00000374333.7
    Conserved Domains (2) summary
    sd00006
    Location:402 → 436
    TPR; TPR repeat [structural motif]
    pfam08631
    Location:175 → 429
    SPO22; Meiosis protein SPO22/ZIP4 like

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    70511227..70908711 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017029649.1 → XP_016885138.1  testis-expressed protein 11 isoform X1

  2. XM_017029650.1 → XP_016885139.1  testis-expressed protein 11 isoform X3

  3. XM_017029651.2 → XP_016885140.1  testis-expressed protein 11 isoform X4

    Related
    ENSP00000363440.2, ENST00000374320.6

  4. XM_017029652.2 → XP_016885141.1  testis-expressed protein 11 isoform X5

  5. XM_011530994.2 → XP_011529296.1  testis-expressed protein 11 isoform X2

    Conserved Domains (2) summary
    sd00006
    Location:402 → 436
    TPR; TPR repeat [structural motif]
    pfam08631
    Location:175 → 429
    SPO22; Meiosis protein SPO22/ZIP4 like

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    68944548..69342011 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054327403.1 → XP_054183378.1  testis-expressed protein 11 isoform X1

  2. XM_054327405.1 → XP_054183380.1  testis-expressed protein 11 isoform X3

  3. XM_054327406.1 → XP_054183381.1  testis-expressed protein 11 isoform X4

  4. XM_054327407.1 → XP_054183382.1  testis-expressed protein 11 isoform X5

  5. XM_054327404.1 → XP_054183379.1  testis-expressed protein 11 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IYF3.3 GenPept UniProtKB/Swiss-Prot:Q8IYF3

Gene LinkOut

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