Stx1b syntaxin 1B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Stx1bprovided by MGI
Official Full Name: syntaxin 1Bprovided by MGI
Primary source: MGI:MGI:1930705
See related: Ensembl:ENSMUSG00000030806 AllianceGenome:MGI:1930705
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Stx1b; Syn1b; Stx1b2; Stx1bl
Summary: Enables protein kinase binding activity and signaling receptor binding activity. Involved in several processes, including modulation of chemical synaptic transmission; negative regulation of synaptic vesicle recycling; and neurotransmitter secretion. Located in axon; plasma membrane; and presynapse. Is active in neuromuscular junction and presynaptic active zone membrane. Is expressed in forebrain and retina layer. Human ortholog(s) of this gene implicated in generalized epilepsy with febrile seizures plus 9. Orthologous to human STX1B (syntaxin 1B). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in cerebellum adult (RPKM 100.1), frontal lobe adult (RPKM 87.7) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F3; 7 69.75 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (127403072..127423703, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (127803900..127824531, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Syntaxin 1B regulates synaptic GABA release and extracellular GABA concentration, and is associated with temperature-dependent seizures.
Title: Syntaxin 1B regulates synaptic GABA release and extracellular GABA concentration, and is associated with temperature-dependent seizures.
Epilepsy-causing STX1B mutations translate altered protein functions into distinct phenotypes in mouse neurons.
Title: Epilepsy-causing STX1B mutations translate altered protein functions into distinct phenotypes in mouse neurons.
Stx1b+/- mice exhibited reduced GABA release both in vitro and in vivo, disrupting the DAergic system in the CNS. Stx1b+/- mice exhibited reduced pre-pulse inhibition.
Title: Syntaxin 1B contributes to regulation of the dopaminergic system through GABA transmission in the CNS.
Results demonstrated that STX1B is essential for the survival of neurons in vitro and it is a critical syntaxin protein for the neurotransmission at the mouse neuromuscular junctions
Title: Syntaxin 1B is important for mouse postnatal survival and proper synaptic function at the mouse neuromuscular junctions.
Although STX1A and STX1B share a basic function as neuronal t-SNAREs, STX1B but not STX1A is necessary for the regulation of spontaneous and evoked synaptic vesicle exocytosis in fast transmission.
Title: Syntaxin 1B, but not syntaxin 1A, is necessary for the regulation of synaptic vesicle exocytosis and of the readily releasable pool at central synapses.
STX1B was important for neuronal survival, possibly by regulating the secretion of neurotrophic factors
Title: HPC-1/syntaxin 1A and syntaxin 1B play distinct roles in neuronal survival.
closed conformation of syntaxin-1 gates the initiation of the synaptic vesicle fusion reaction, which is then mediated by SNARE-complex/Munc18-1 assemblies
Title: Conformational switch of syntaxin-1 controls synaptic vesicle fusion.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SNAP receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables SNAP receptor activity	IEA Inferred from Electronic Annotation more info
enables SNARE binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in calcium ion-regulated exocytosis of neurotransmitter	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in exocytic insertion of neurotransmitter receptor to postsynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in exocytic insertion of neurotransmitter receptor to postsynaptic membrane	ISO Inferred from Sequence Orthology more info
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of macropinocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of neuron projection development	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of synaptic vesicle recycling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of excitatory postsynaptic potential	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of neurotransmitter secretion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of spontaneous neurotransmitter secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to membrane	ISO Inferred from Sequence Orthology more info
involved_in regulation of exocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic vesicle priming	IGI Inferred from Genetic Interaction more info	PubMed
involved_in spontaneous neurotransmitter secretion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in spontaneous neurotransmitter secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle docking	IGI Inferred from Genetic Interaction more info	PubMed
involved_in synaptic vesicle docking	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle exocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in synaptic vesicle exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle fusion to presynaptic active zone membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in synaptic vesicle fusion to presynaptic active zone membrane	IEP Inferred from Expression Pattern more info	PubMed
involved_in synaptic vesicle fusion to presynaptic active zone membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle docking	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle docking involved in exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle-mediated transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of SNARE complex	IBA Inferred from Biological aspect of Ancestor more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuromuscular junction	IEP Inferred from Expression Pattern more info	PubMed
is_active_in neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed
located_in nuclear lamina	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in presynapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in presynaptic active zone membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic active zone membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in presynaptic active zone membrane	ISO Inferred from Sequence Orthology more info
located_in presynaptic membrane	IC Inferred by Curator more info
located_in presynaptic membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: syntaxin-1B

Names: syntaxin 1B1; syntaxin 1B2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_024414.2 → NP_077725.1 syntaxin-1B

See identical proteins and their annotated locations for NP_077725.1

Status: VALIDATED

Source sequence(s)

AC149222

Consensus CDS

CCDS40146.1

UniProtKB/Swiss-Prot

A2RSB4, O35525, P32853, P61264

Related

ENSMUSP00000101874.4, ENSMUST00000106267.5

Conserved Domains (2) summary

pfam00804
Location:29 → 226

Syntaxin

pfam05739
Location:227 → 278

SNARE; SNARE domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

127403072..127423703 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011241866.1 → XP_011240168.1 syntaxin-1B isoform X2

Conserved Domains (2) summary

pfam00804
Location:25 → 222

Syntaxin

pfam05739
Location:223 → 274

SNARE; SNARE domain
XM_006508044.4 → XP_006508107.1 syntaxin-1B isoform X1

Conserved Domains (2) summary

pfam00804
Location:147 → 344

Syntaxin

pfam05739
Location:345 → 396

SNARE; SNARE domain
XM_036153269.1 → XP_036009162.1 syntaxin-1B isoform X3

Conserved Domains (2) summary

pfam00804
Location:1 → 198

Syntaxin

pfam05739
Location:199 → 250

SNARE; SNARE domain