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Fscn3 fascin actin-bundling protein 3 [ Mus musculus (house mouse) ]

Gene ID: 56223, updated on 2-Nov-2024

Summary

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Official Symbol
Fscn3provided by MGI
Official Full Name
fascin actin-bundling protein 3provided by MGI
Primary source
MGI:MGI:1890386
See related
Ensembl:ENSMUSG00000029707 AllianceGenome:MGI:1890386
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable actin filament binding activity. Predicted to be involved in actin filament bundle assembly; cell migration; and establishment or maintenance of cell polarity. Predicted to act upstream of or within spermatid development. Located in cytoplasm. Is expressed in testis. Orthologous to human FSCN3 (fascin actin-bundling protein 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward testis adult (RPKM 130.6) See more
Orthologs
human all
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Genomic context

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See Fscn3 in Genome Data Viewer
Location:
6 A3.3; 6 11.99 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (28427888..28438621)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (28427870..28438622)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 800 Neighboring gene STARR-seq mESC enhancer starr_15409 Neighboring gene kelch domain containing pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr6:28371614-28371915 Neighboring gene Pax4 5' regulatory region Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:28430124-28430311 Neighboring gene golgi coiled coil 1 Neighboring gene ADP-ribosylation factor 5 Neighboring gene paired box 4 Neighboring gene staphylococcal nuclease and tudor domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_15418 Neighboring gene leucine rich repeat containing 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Testis-specific fascin component FSCN3 is dispensable for mouse spermatogenesis and fertility. Ali H, et al. Mol Biol Rep, 2022 Jul. PMID 35449315
  2. Fascin1 is dispensable for mouse development but is favorable for neonatal survival. Yamakita Y, et al. Cell Motil Cytoskeleton, 2009 Aug. PMID 19343791, Free PMC Article
  3. Testis fascin (FSCN3): a novel paralog of the actin-bundling protein fascin expressed specifically in the elongate spermatid head. Tubb B, et al. Exp Cell Res, 2002 Apr 15. PMID 11925108
  4. Identification of candidate alkylator-induced cancer susceptibility genes by whole genome scanning in mice. Fenske TS, et al. Cancer Res, 2006 May 15. PMID 16707424
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Testis-specific fascin component FSCN3 is dispensable for mouse spermatogenesis and fertility.
    Title: Testis-specific fascin component FSCN3 is dispensable for mouse spermatogenesis and fertility.
  2. This is a novel, spermatid-specific murine paralog of the actin-binding protein fascin FSCN1. Its expression is restricted to the elongated spermatid head.
    Title: Testis fascin (FSCN3): a novel paralog of the actin-bundling protein fascin expressed specifically in the elongate spermatid head.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding ISA
Inferred from Sequence Alignment
more info
 PubMed 
enables actin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin filament binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein-macromolecule adaptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actin cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in actin filament bundle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin filament organization IEA
Inferred from Electronic Annotation
more info
  
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment or maintenance of cell polarity IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within spermatid development TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in actin cytoskeleton ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cell projection membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in filopodium IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in growth cone IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in lamellipodium IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in microvillus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in ruffle IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
fascin-3
Names
fascin (testis)
fascin homolog 3, actin-bundling protein, testicular
testis fascin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001411255.1 → NP_001398184.1  fascin-3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC068608

  2. NM_019569.3 → NP_062515.2  fascin-3 isoform 1

    See identical proteins and their annotated locations for NP_062515.2

    Status: VALIDATED

    Source sequence(s)
    AC068608
    Consensus CDS
    CCDS39446.1
    UniProtKB/Swiss-Prot
    Q80YU6, Q9QXW4
    Related
    ENSMUSP00000031719.7, ENSMUST00000031719.7
    Conserved Domains (2) summary
    cd00257
    Location:263 → 381
    Fascin; Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an ...
    pfam06268
    Location:24 → 138
    Fascin; Fascin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    28427888..28438621
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QXW4.2 GenPept UniProtKB/Swiss-Prot:Q9QXW4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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