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Higd1a HIG1 domain family, member 1A [ Mus musculus (house mouse) ]

Gene ID: 56295, updated on 2-Nov-2024

Summary

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Official Symbol
Higd1aprovided by MGI
Official Full Name
HIG1 domain family, member 1Aprovided by MGI
Primary source
MGI:MGI:1930666
See related
Ensembl:ENSMUSG00000038412 AllianceGenome:MGI:1930666
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hig1; HIMP1; 2210020B17Rik; 7420700H20Rik
Summary
Acts upstream of or within several processes, including cellular response to glucose starvation; negative regulation of release of cytochrome c from mitochondria; and positive regulation of protein serine/threonine kinase activity. Located in mitochondrial inner membrane and nucleus. Is expressed in cerebral cortex ventricular layer; cortical plate; and embryo. Orthologous to human HIGD1A (HIG1 hypoxia inducible domain family member 1A). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in cerebellum adult (RPKM 19.8), frontal lobe adult (RPKM 17.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Higd1a in Genome Data Viewer
Location:
9 F4; 9 72.67 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (121677623..121686862, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (121848557..121857796, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene hedgehog acyltransferase-like Neighboring gene coiled-coil domain containing 13 Neighboring gene predicted gene, 51698 Neighboring gene STARR-positive B cell enhancer ABC_E3869 Neighboring gene predicted gene, 47112 Neighboring gene predicted gene, 47113 Neighboring gene atypical chemokine receptor 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Higd1a facilitates exercise-mediated alleviation of fatty liver in diet-induced obese mice. Zhu JY, et al. Metabolism, 2022 Sep. PMID 35750235
  2. Mitochondrial HIGD1A inhibits hepatitis B virus transcription and replication through the cellular PNKD-NF-κB-NR2F1 nexus. Xie Z, et al. J Med Virol, 2023 Apr. PMID 37185850
  3. Higd1a Protects Cells from Lipotoxicity under High-Fat Exposure. Li T, et al. Oxid Med Cell Longev, 2019. PMID 31089410, Free PMC Article
  4. HIGD1A links SIRT1 activity to adipose browning by inhibiting the ROS/DNA damage pathway. Li BY, et al. Cell Rep, 2023 Jul 25. PMID 37393616
  5. Pancreatic beta cells lack a low glucose and O2-inducible mitochondrial protein that augments cell survival. Wang J, et al. Proc Natl Acad Sci U S A, 2006 Jul 11. PMID 16815968, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. HIGD1A links SIRT1 activity to adipose browning by inhibiting the ROS/DNA damage pathway.
    Title: HIGD1A links SIRT1 activity to adipose browning by inhibiting the ROS/DNA damage pathway.
  2. Mitochondrial HIGD1A inhibits hepatitis B virus transcription and replication through the cellular PNKD-NF-kappaB-NR2F1 nexus.
    Title: Mitochondrial HIGD1A inhibits hepatitis B virus transcription and replication through the cellular PNKD-NF-κB-NR2F1 nexus.
  3. Higd1a facilitates exercise-mediated alleviation of fatty liver in diet-induced obese mice.
    Title: Higd1a facilitates exercise-mediated alleviation of fatty liver in diet-induced obese mice.
  4. Higd1a plays positive roles in protecting cells from oxidative stress, and reactive oxygen species could induce Higd1a expression by upregulating PGC-1a and HIF-1a expressions.
    Title: Higd1a Protects Cells from Lipotoxicity under High-Fat Exposure.
  5. Important role in stress protective programs in mitochondria.
    Title: Pancreatic beta cells lack a low glucose and O2-inducible mitochondrial protein that augments cell survival.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to glucose starvation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within cellular response to glucose starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cellular response to hypoxia IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within cellular response to hypoxia IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial respirasome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of release of cytochrome c from mitochondria IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
HIG1 domain family member 1A, mitochondrial
Names
hypoxia induced gene 1
hypoxia-inducible gene 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357837.1 → NP_001344766.1  HIG1 domain family member 1A, mitochondrial

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All six variants encode the same protein.
    Source sequence(s)
    AC165080, AI303276, AK018360, BE457620, CJ042199
    Consensus CDS
    CCDS40812.1
    UniProtKB/Swiss-Prot
    Q9JLR9
    UniProtKB/TrEMBL
    A0A1L1ST61, Q1XG81
    Conserved Domains (1) summary
    pfam04588
    Location:28 → 76
    HIG_1_N; Hypoxia induced protein conserved region

  2. NM_001357838.1 → NP_001344767.1  HIG1 domain family member 1A, mitochondrial

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All six variants encode the same protein.
    Source sequence(s)
    AA414831, AI303276, AK018360, BE457620
    Consensus CDS
    CCDS40812.1
    UniProtKB/Swiss-Prot
    Q9JLR9
    UniProtKB/TrEMBL
    A0A1L1ST61, Q1XG81
    Related
    ENSMUSP00000149531.2, ENSMUST00000213124.2
    Conserved Domains (1) summary
    pfam04588
    Location:28 → 76
    HIG_1_N; Hypoxia induced protein conserved region

  3. NM_001357839.1 → NP_001344768.1  HIG1 domain family member 1A, mitochondrial

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All six variants encode the same protein.
    Source sequence(s)
    AI303276, AK018360, BE457620, CJ042267
    Consensus CDS
    CCDS40812.1
    UniProtKB/Swiss-Prot
    Q9JLR9
    UniProtKB/TrEMBL
    A0A1L1ST61, Q1XG81
    Conserved Domains (1) summary
    pfam04588
    Location:28 → 76
    HIG_1_N; Hypoxia induced protein conserved region

  4. NM_001357840.1 → NP_001344769.1  HIG1 domain family member 1A, mitochondrial

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All six variants encode the same protein.
    Source sequence(s)
    AI303276, AK018360, BE457620, BE689839
    Consensus CDS
    CCDS40812.1
    UniProtKB/Swiss-Prot
    Q9JLR9
    UniProtKB/TrEMBL
    A0A1L1ST61, Q1XG81
    Related
    ENSMUSP00000150726.2, ENSMUST00000215300.2
    Conserved Domains (1) summary
    pfam04588
    Location:28 → 76
    HIG_1_N; Hypoxia induced protein conserved region

  5. NM_001357841.1 → NP_001344770.1  HIG1 domain family member 1A, mitochondrial

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. All six variants encode the same protein.
    Source sequence(s)
    AI303276, AK018360, BE457620, BU851504
    Consensus CDS
    CCDS40812.1
    UniProtKB/Swiss-Prot
    Q9JLR9
    UniProtKB/TrEMBL
    A0A1L1ST61, Q1XG81
    Conserved Domains (1) summary
    pfam04588
    Location:28 → 76
    HIG_1_N; Hypoxia induced protein conserved region

  6. NM_019814.5 → NP_062788.1  HIG1 domain family member 1A, mitochondrial

    See identical proteins and their annotated locations for NP_062788.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. All six variants encode the same protein.
    Source sequence(s)
    AI303276, AK018360, BE457620
    Consensus CDS
    CCDS40812.1
    UniProtKB/Swiss-Prot
    Q9JLR9
    UniProtKB/TrEMBL
    A0A1L1ST61, Q1XG81
    Related
    ENSMUSP00000054881.7, ENSMUST00000060251.8
    Conserved Domains (1) summary
    pfam04588
    Location:28 → 76
    HIG_1_N; Hypoxia induced protein conserved region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    121677623..121686862 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JLR9.1 GenPept UniProtKB/Swiss-Prot:Q9JLR9

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