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Txnip thioredoxin interacting protein [ Mus musculus (house mouse) ]

Gene ID: 56338, updated on 28-Oct-2024

Summary

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Official Symbol
Txnipprovided by MGI
Official Full Name
thioredoxin interacting proteinprovided by MGI
Primary source
MGI:MGI:1889549
See related
Ensembl:ENSMUSG00000038393 AllianceGenome:MGI:1889549
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
THIF; Tbp-2; VDUP1; Hyplip1; 1200008J08Rik
Summary
Enables enzyme inhibitor activity. Acts upstream of or within several processes, including negative regulation of transcription by RNA polymerase II; platelet-derived growth factor receptor signaling pathway; and protein import into nucleus. Located in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Used to study Reye syndrome and hepatocellular carcinoma. Orthologous to human TXNIP (thioredoxin interacting protein). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Broad expression in subcutaneous fat pad adult (RPKM 279.2), lung adult (RPKM 241.9) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Txnip in Genome Data Viewer
Location:
3 F2.1; 3 41.93 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (96465273..96469173)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (96557957..96561857)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_08437 Neighboring gene predicted gene, 40100 Neighboring gene hemojuvelin BMP co-receptor Neighboring gene STARR-positive B cell enhancer mm9_chr3:96351291-96351592 Neighboring gene STARR-positive B cell enhancer ABC_E6082 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:96361830-96361983 Neighboring gene STARR-seq mESC enhancer starr_08439 Neighboring gene predicted gene 15441 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:96368663-96368826 Neighboring gene STARR-seq mESC enhancer starr_08441 Neighboring gene STARR-positive B cell enhancer ABC_E6083 Neighboring gene polymerase (RNA) III (DNA directed) polypeptide G like Neighboring gene STARR-seq mESC enhancer starr_08442 Neighboring gene STARR-positive B cell enhancer ABC_E3451 Neighboring gene ankyrin repeat domain 34A Neighboring gene predicted gene, 52628

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Txnip C247S mutation protects the heart against acute myocardial infarction. Nakayama Y, et al. J Mol Cell Cardiol, 2021 Jun. PMID 33652022, Free PMC Article
  2. VDUP1 exacerbates bacteremic shock in mice infected with Pseudomonas aeruginosa. Piao ZH, et al. Cell Immunol, 2012 Nov. PMID 23246829
  3. Thioredoxin-interacting protein mediates ER stress-induced β cell death through initiation of the inflammasome. Oslowski CM, et al. Cell Metab, 2012 Aug 8. PMID 22883234, Free PMC Article
  4. Thioredoxin-interacting protein: a critical link between autophagy disorders and pancreatic β-cell dysfunction. Deng W, et al. Endocrine, 2020 Dec. PMID 32892310
  5. The thioredoxin-1 inhibitor Txnip restrains effector T-cell and germinal center B-cell expansion. Muri J, et al. Eur J Immunol, 2021 Jan. PMID 32902872

See all (233) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Targeting TXNIP in endothelial progenitors mitigates IL-8-induced neutrophil recruitment under metabolic stress.
    Title: Targeting TXNIP in endothelial progenitors mitigates IL-8-induced neutrophil recruitment under metabolic stress.
  2. piR112710 attenuates diabetic cardiomyopathy through inhibiting Txnip/NLRP3-mediated pyroptosis in db/db mice.
    Title: piR112710 attenuates diabetic cardiomyopathy through inhibiting Txnip/NLRP3-mediated pyroptosis in db/db mice.
  3. A novel link between melatonin and circ_0005753/PTBP1/TXNIP regulatory network in the modulation of osteogenic potential in mesenchymal stem cells.
    Title: A novel link between melatonin and circ_0005753/PTBP1/TXNIP regulatory network in the modulation of osteogenic potential in mesenchymal stem cells.
  4. Txnip deletions and missense alleles prolong the survival of cones in a retinitis pigmentosa mouse model.
    Title: Txnip deletions and missense alleles prolong the survival of cones in a retinitis pigmentosa mouse model.
  5. METTL3 Modulates TXNIP Expression to Affect the Activation of NLRP3 Inflammasome in Hepatic Cells Under Oxygen-Glucose Deprivation/Reperfusion Injury.
    Title: METTL3 Modulates TXNIP Expression to Affect the Activation of NLRP3 Inflammasome in Hepatic Cells Under Oxygen-Glucose Deprivation/Reperfusion Injury.
  6. Txnip regulates the Oct4-mediated pluripotency circuitry via metabolic changes upon differentiation.
    Title: Txnip regulates the Oct4-mediated pluripotency circuitry via metabolic changes upon differentiation.
  7. FoxO6-Mediated TXNIP Induces Lipid Accumulation in the Liver through NLRP3 Inflammasome Activation.
    Title: FoxO6-Mediated TXNIP Induces Lipid Accumulation in the Liver through NLRP3 Inflammasome Activation.
  8. Deficiency of thioredoxin-interacting protein results in age-related thrombocytopenia due to megakaryocyte oxidative stress.
    Title: Deficiency of thioredoxin-interacting protein results in age-related thrombocytopenia due to megakaryocyte oxidative stress.
  9. Zbtb16 increases susceptibility of atrial fibrillation in type 2 diabetic mice via Txnip-Trx2 signaling.
    Title: Zbtb16 increases susceptibility of atrial fibrillation in type 2 diabetic mice via Txnip-Trx2 signaling.
  10. Exosomal OIP5-AS1 attenuates cerebral ischemia-reperfusion injury by negatively regulating TXNIP protein stability and inhibiting neuronal pyroptosis.
    Title: Exosomal OIP5-AS1 attenuates cerebral ischemia-reperfusion injury by negatively regulating TXNIP protein stability and inhibiting neuronal pyroptosis.
Submit: New GeneRIF Correction See all GeneRIFs (171)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables enzyme inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular response to tumor cell ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to tumor cell ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in keratinocyte differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in keratinocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell division ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell division ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within platelet-derived growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in response to calcium ion IEA
Inferred from Electronic Annotation
more info
  
involved_in response to estradiol IEA
Inferred from Electronic Annotation
more info
  
involved_in response to glucose IEA
Inferred from Electronic Annotation
more info
  
involved_in response to hydrogen peroxide IEA
Inferred from Electronic Annotation
more info
  
involved_in response to mechanical stimulus IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to oxidative stress IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to oxidative stress ISO
Inferred from Sequence Orthology
more info
  
involved_in response to progesterone IEA
Inferred from Electronic Annotation
more info
  
involved_in response to xenobiotic stimulus IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
thioredoxin-interacting protein
Names
hyperlipidemia 1
thioredoxin binding protein-2
upregulated by 1,25-dihydroxyvitamin D-3
vitamin D3 up-regulated protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009935.2 → NP_001009935.1  thioredoxin-interacting protein isoform 1

    See identical proteins and their annotated locations for NP_001009935.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC122037
    Consensus CDS
    CCDS38555.1
    UniProtKB/Swiss-Prot
    Q8BG60, Q8BGQ0, Q8K2B2, Q9DC00, Q9EP90, Q9R115
    UniProtKB/TrEMBL
    Q91X82
    Related
    ENSMUSP00000102710.3, ENSMUST00000074519.13
    Conserved Domains (2) summary
    pfam02752
    Location:175 → 299
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    cl22903
    Location:10 → 153
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain

  2. NM_023719.2 → NP_076208.2  thioredoxin-interacting protein isoform 2

    See identical proteins and their annotated locations for NP_076208.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
    Source sequence(s)
    AK089403, AK171456
    Consensus CDS
    CCDS17640.1
    UniProtKB/TrEMBL
    Q91X82
    Related
    ENSMUSP00000041467.8, ENSMUST00000049093.8
    Conserved Domains (2) summary
    pfam02752
    Location:174 → 298
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    cl22903
    Location:10 → 152
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    96465273..96469173
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BG60.1 GenPept UniProtKB/Swiss-Prot:Q8BG60

Gene LinkOut

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