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Stx5a syntaxin 5A [ Mus musculus (house mouse) ]

Gene ID: 56389, updated on 28-Oct-2024

Summary

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Official Symbol
Stx5aprovided by MGI
Official Full Name
syntaxin 5Aprovided by MGI
Primary source
MGI:MGI:1928483
See related
Ensembl:ENSMUSG00000010110 AllianceGenome:MGI:1928483
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Stx5; D19Ertd627e; 0610031F24Rik
Summary
Predicted to enable SNAP receptor activity and SNARE binding activity. Predicted to be involved in several processes, including Golgi disassembly; Golgi vesicle transport; and regulation of Golgi organization. Predicted to act upstream of or within vesicle-mediated transport. Predicted to be located in Golgi apparatus and vesicle. Predicted to be part of SNARE complex. Predicted to be active in Golgi membrane. Is expressed in mesenchyme of metanephros and metanephros epithelium. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type II. Orthologous to human STX5 (syntaxin 5). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in limb E14.5 (RPKM 35.3), ovary adult (RPKM 26.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Stx5a in Genome Data Viewer
Location:
19 A; 19 5.45 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (8718788..8733006)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (8741424..8755642)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene WD repeat domain 74 Neighboring gene STARR-positive B cell enhancer ABC_E2518 Neighboring gene testis expressed 54 Neighboring gene microRNA 6992 Neighboring gene RIKEN cDNA 1700023D09 gene Neighboring gene STARR-seq mESC enhancer starr_45493 Neighboring gene nuclear RNA export factor 1 Neighboring gene transmembrane protein 223

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Syntaxin 5 regulates the endoplasmic reticulum channel-release properties of polycystin-2. Geng L, et al. Proc Natl Acad Sci U S A, 2008 Oct 14. PMID 18836075, Free PMC Article
  2. Mice lacking WRB reveal differential biogenesis requirements of tail-anchored proteins in vivo. Rivera-Monroy J, et al. Sci Rep, 2016 Dec 21. PMID 28000760, Free PMC Article
  3. Syntaxin 3 and Munc-18-2 in epithelial cells during kidney development. Lehtonen S, et al. Kidney Int, 1999 Sep. PMID 10469351
  4. Ykt6 forms a SNARE complex with syntaxin 5, GS28, and Bet1 and participates in a late stage in endoplasmic reticulum-Golgi transport. Zhang T, et al. J Biol Chem, 2001 Jul 20. PMID 11323436
  5. A natural allele of Nxf1 suppresses retrovirus insertional mutations. Floyd JA, et al. Nat Genet, 2003 Nov. PMID 14517553, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SNAP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SNAP receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables SNAP receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Golgi disassembly ISO
Inferred from Sequence Orthology
more info
  
involved_in early endosome to Golgi transport ISO
Inferred from Sequence Orthology
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in membrane fusion IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of Golgi organization ISO
Inferred from Sequence Orthology
more info
  
involved_in retrograde transport, endosome to Golgi ISO
Inferred from Sequence Orthology
more info
  
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
involved_in vesicle docking IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle fusion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle fusion with Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within vesicle-mediated transport TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi membrane TAS
Traceable Author Statement
more info
 PubMed 
part_of SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SNARE complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum-Golgi intermediate compartment membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vesicle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
syntaxin-5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001167799.1 → NP_001161271.1  syntaxin-5

    See identical proteins and their annotated locations for NP_001161271.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants encode the same protein.
    Source sequence(s)
    BQ030996, CK389576, CN539678, DV649852
    Consensus CDS
    CCDS29542.2
    UniProtKB/Swiss-Prot
    Q3TM79, Q8K1E0, Q99J28, Q9JKP2
    Related
    ENSMUSP00000134854.2, ENSMUST00000176381.8
    Conserved Domains (3) summary
    COG5325
    Location:94 → 324
    COG5325; t-SNARE complex subunit, syntaxin [Intracellular trafficking and secretion]
    cd15844
    Location:266 → 338
    SNARE_syntaxin5; SNARE motif of syntaxin 5
    pfam11416
    Location:53 → 74
    Syntaxin-5_N; Syntaxin-5 N-terminal, Sly1p-binding domain

  2. NM_019829.4 → NP_062803.4  syntaxin-5

    See identical proteins and their annotated locations for NP_062803.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants encode the same protein.
    Source sequence(s)
    AC025794, BQ030996, CN539678, DV649852
    Consensus CDS
    CCDS29542.2
    UniProtKB/Swiss-Prot
    Q3TM79, Q8K1E0, Q99J28, Q9JKP2
    Related
    ENSMUSP00000073136.8, ENSMUST00000073430.14
    Conserved Domains (3) summary
    COG5325
    Location:94 → 324
    COG5325; t-SNARE complex subunit, syntaxin [Intracellular trafficking and secretion]
    cd15844
    Location:266 → 338
    SNARE_syntaxin5; SNARE motif of syntaxin 5
    pfam11416
    Location:53 → 74
    Syntaxin-5_N; Syntaxin-5 N-terminal, Sly1p-binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    8718788..8733006
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030251000.2 → XP_030106860.1  syntaxin-5 isoform X1

    UniProtKB/Swiss-Prot
    Q3TM79, Q8K1E0, Q99J28, Q9JKP2
    Conserved Domains (3) summary
    COG5325
    Location:94 → 324
    COG5325; t-SNARE complex subunit, syntaxin [Intracellular trafficking and secretion]
    cd15844
    Location:266 → 338
    SNARE_syntaxin5; SNARE motif of syntaxin 5
    pfam11416
    Location:53 → 74
    Syntaxin-5_N; Syntaxin-5 N-terminal, Sly1p-binding domain

  2. XM_030250998.2 → XP_030106858.1  syntaxin-5 isoform X1

    UniProtKB/Swiss-Prot
    Q3TM79, Q8K1E0, Q99J28, Q9JKP2
    Conserved Domains (3) summary
    COG5325
    Location:94 → 324
    COG5325; t-SNARE complex subunit, syntaxin [Intracellular trafficking and secretion]
    cd15844
    Location:266 → 338
    SNARE_syntaxin5; SNARE motif of syntaxin 5
    pfam11416
    Location:53 → 74
    Syntaxin-5_N; Syntaxin-5 N-terminal, Sly1p-binding domain

  3. XM_030250999.2 → XP_030106859.1  syntaxin-5 isoform X1

    UniProtKB/Swiss-Prot
    Q3TM79, Q8K1E0, Q99J28, Q9JKP2
    Conserved Domains (3) summary
    COG5325
    Location:94 → 324
    COG5325; t-SNARE complex subunit, syntaxin [Intracellular trafficking and secretion]
    cd15844
    Location:266 → 338
    SNARE_syntaxin5; SNARE motif of syntaxin 5
    pfam11416
    Location:53 → 74
    Syntaxin-5_N; Syntaxin-5 N-terminal, Sly1p-binding domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K1E0.3 GenPept UniProtKB/Swiss-Prot:Q8K1E0

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