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Orc6 origin recognition complex, subunit 6 [ Mus musculus (house mouse) ]

Gene ID: 56452, updated on 2-Nov-2024

Summary

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Official Symbol
Orc6provided by MGI
Official Full Name
origin recognition complex, subunit 6provided by MGI
Primary source
MGI:MGI:1929285
See related
Ensembl:ENSMUSG00000031697 AllianceGenome:MGI:1929285
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Orc6l; 6720420I10Rik
Summary
Predicted to enable DNA binding activity. Acts upstream of or within DNA-templated DNA replication. Predicted to be located in fibrillar center and nucleoplasm. Predicted to be part of nuclear origin of replication recognition complex. Is expressed in several structures, including brain ventricular layer; early conceptus; jaw; liver lobe; and submandibular gland primordium. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 3. Orthologous to human ORC6 (origin recognition complex subunit 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in liver E14 (RPKM 33.8), CNS E11.5 (RPKM 28.8) and 21 other tissues See more
Orthologs
human all
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Genomic context

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See Orc6 in Genome Data Viewer
Location:
8 C3; 8 41.61 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (86026261..86034908)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (85299632..85308279)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 7 subfamily C member 19 Neighboring gene STARR-seq mESC enhancer starr_22152 Neighboring gene VPS35 retromer complex component Neighboring gene STARR-positive B cell enhancer ABC_E9120 Neighboring gene predicted gene, 22336 Neighboring gene myosin light chain kinase 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Recruitment of Orc6l, a dormant maternal mRNA in mouse oocytes, is essential for DNA replication in 1-cell embryos. Murai S, et al. Dev Biol, 2010 May 1. PMID 20219456, Free PMC Article
  2. The dynamic nature of the human origin recognition complex revealed through five cryoEM structures. Jaremko MJ, et al. Elife, 2020 Aug 18. PMID 32808929, Free PMC Article
  3. Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells. Kneissl M, et al. J Mol Biol, 2003 Mar 14. PMID 12614612
  4. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579
  5. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Study reports that ORC6L is another component required for acquisition of DNA replication competence that is absent in mouse oocytes.
    Title: Recruitment of Orc6l, a dormant maternal mRNA in mouse oocytes, is essential for DNA replication in 1-cell embryos.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC91038

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA replication initiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within DNA-templated DNA replication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
  
part_of nuclear origin of replication recognition complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nuclear origin of replication recognition complex ISO
Inferred from Sequence Orthology
more info
  
part_of nuclear origin of replication recognition complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of origin recognition complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
origin recognition complex subunit 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163791.1 → NP_001157263.1  origin recognition complex subunit 6 isoform b

    See identical proteins and their annotated locations for NP_001157263.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    AC134854, AK078405, AK163256, BF661105, BP771997
    Consensus CDS
    CCDS52623.1
    UniProtKB/TrEMBL
    Q3TQX1
    Related
    ENSMUSP00000126925.2, ENSMUST00000170141.3
    Conserved Domains (2) summary
    cd11583
    Location:18 → 110
    Orc6_mid; Middle domain of the origin recognition complex subunit 6
    cd16075
    Location:135 → 183
    ORC6_CTD; C-terminal domain of the eukaryotic origin recognition complex subunit ORC6

  2. NM_019716.2 → NP_062690.2  origin recognition complex subunit 6 isoform a

    See identical proteins and their annotated locations for NP_062690.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC134854, AK078405, AK163256, BC080739, BF661105, BP771997
    Consensus CDS
    CCDS22497.1
    UniProtKB/Swiss-Prot
    Q9WUJ8
    UniProtKB/TrEMBL
    Q66JV6
    Related
    ENSMUSP00000034132.6, ENSMUST00000034132.13
    Conserved Domains (3) summary
    cd11583
    Location:94 → 186
    Orc6_mid; Middle domain of the origin recognition complex subunit 6
    pfam05460
    Location:6 → 94
    ORC6; Origin recognition complex subunit 6 (ORC6)
    cd16075
    Location:211 → 259
    ORC6_CTD; C-terminal domain of the eukaryotic origin recognition complex subunit ORC6

RNA

  1. NR_028268.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC134854, AK078405, AK163256, BC080739, BF661105, BP771997

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    86026261..86034908
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WUJ8.1 GenPept UniProtKB/Swiss-Prot:Q9WUJ8

Gene LinkOut

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