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Cnpy2 canopy FGF signaling regulator 2 [ Mus musculus (house mouse) ]

Gene ID: 56530, updated on 28-Oct-2024

Summary

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Official Symbol
Cnpy2provided by MGI
Official Full Name
canopy FGF signaling regulator 2provided by MGI
Primary source
MGI:MGI:1928477
See related
Ensembl:ENSMUSG00000025381 AllianceGenome:MGI:1928477
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tmem4; Zsig9; D10Bwg1546e; 5330432A10Rik
Summary
Predicted to be active in endoplasmic reticulum. Is expressed in embryo. Orthologous to human CNPY2 (canopy FGF signaling regulator 2). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in placenta adult (RPKM 39.1), limb E14.5 (RPKM 36.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Cnpy2 in Genome Data Viewer
Location:
10 D3; 10 76.52 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (128157972..128163056)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (128322158..128327187)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E194 Neighboring gene interleukin 23, alpha subunit p19 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:127740631-127740818 Neighboring gene predicted gene, 23241 Neighboring gene PAN2 poly(A) specific ribonuclease subunit Neighboring gene STARR-positive B cell enhancer ABC_E9813 Neighboring gene STARR-positive B cell enhancer ABC_E1134 Neighboring gene STARR-positive B cell enhancer ABC_E11467 Neighboring gene citrate synthase Neighboring gene predicted gene, 23182 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:127806017-127806126 Neighboring gene coenzyme Q10A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The role of CNPY2 in endothelial injury and inflammation during the progress of atherosclerosis. Huang H, et al. J Mol Histol, 2023 Jun. PMID 37103758
  2. Canopy Homolog 2 contributes to liver oncogenesis by promoting unfolded protein response-dependent destabilization of tumor protein P53. Hong F, et al. Hepatology, 2022 Dec. PMID 34986508
  3. Expression of CNPY2 in mouse tissues: quantification and localization. Hatta K, et al. PLoS One, 2014. PMID 25393402, Free PMC Article
  4. A secreted protein (Canopy 2, CNPY2) enhances angiogenesis and promotes smooth muscle cell migration and proliferation. Guo J, et al. Cardiovasc Res, 2015 Mar 1. PMID 25589425
  5. Decreasing CNPY2 Expression Diminishes Colorectal Tumor Growth and Development through Activation of p53 Pathway. Yan P, et al. Am J Pathol, 2016 Apr. PMID 26835537

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The role of CNPY2 in endothelial injury and inflammation during the progress of atherosclerosis.
    Title: The role of CNPY2 in endothelial injury and inflammation during the progress of atherosclerosis.
  2. Canopy Homolog 2 contributes to liver oncogenesis by promoting unfolded protein response-dependent destabilization of tumor protein P53.
    Title: Canopy Homolog 2 contributes to liver oncogenesis by promoting unfolded protein response-dependent destabilization of tumor protein P53.
  3. Sustained PERK activation can amplify PERK signaling by further enhancing CNPY2 expression via direct transactivation through CHOP.
    Title: Fine-tuning PERK signaling to control cell fate under stress.
  4. Free CNPY2 then engages protein kinase R-like endoplasmic reticulum kinase (PERK) to induce expression of the transcription factor C/EBP homologous protein (CHOP), thereby initiating the unfolded protein response.
    Title: CNPY2 is a key initiator of the PERK-CHOP pathway of the unfolded protein response.
  5. CNPY2 may play a critical role in colorectal cancer development by enhancing cell proliferation, migration, and angiogenesis and by inhibiting apoptosis through negative regulation of the p53 pathway
    Title: Decreasing CNPY2 Expression Diminishes Colorectal Tumor Growth and Development through Activation of p53 Pathway.
  6. The data demonstrate CNPY2 is widely distributed in tissues and suggest the protein has biological functions that have yet to be identified.
    Title: Expression of CNPY2 in mouse tissues: quantification and localization.
  7. CNPY2 is a HIF-1alpha-regulated, secreted angiogenic growth factor that promotes smooth muscle cell migration, proliferation, and tissue revascularization.
    Title: A secreted protein (Canopy 2, CNPY2) enhances angiogenesis and promotes smooth muscle cell migration and proliferation.
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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 
  • Targeted (2)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of positive regulation of low-density lipoprotein receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of regulation of low-density lipoprotein particle clearance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein canopy homolog 2
Names
MIR-interacting saposin-like protein
canopy 2 homolog
putative secreted protein ZSIG9
transmembrane protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001429229.1 → NP_001416158.1  protein canopy homolog 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC090489
    UniProtKB/Swiss-Prot
    Q3UBH8, Q9QXT0

  2. NM_001429230.1 → NP_001416159.1  protein canopy homolog 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC090489
    UniProtKB/Swiss-Prot
    Q3UBH8, Q9QXT0

  3. NM_001429231.1 → NP_001416160.1  protein canopy homolog 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC090489
    UniProtKB/Swiss-Prot
    Q3UBH8, Q9QXT0

  4. NM_001429232.1 → NP_001416161.1  protein canopy homolog 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC090489
    UniProtKB/Swiss-Prot
    Q3UBH8, Q9QXT0

  5. NM_019953.2 → NP_064337.1  protein canopy homolog 2 precursor

    See identical proteins and their annotated locations for NP_064337.1

    Status: VALIDATED

    Source sequence(s)
    AC090489
    Consensus CDS
    CCDS24272.1
    UniProtKB/Swiss-Prot
    Q3UBH8, Q9QXT0
    Related
    ENSMUSP00000151918.2, ENSMUST00000219037.2
    Conserved Domains (1) summary
    pfam11938
    Location:27 → 165
    DUF3456; TLR4 regulator and MIR-interacting MSAP

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    128157972..128163056
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513902.5 → XP_006513965.1  protein canopy homolog 2 isoform X2

    Related
    ENSMUSP00000026446.3, ENSMUST00000026446.4
    Conserved Domains (1) summary
    pfam11938
    Location:27 → 165
    DUF3456; TLR4 regulator and MIR-interacting MSAP

  2. XM_030245184.2 → XP_030101044.1  protein canopy homolog 2 isoform X1

    Conserved Domains (1) summary
    pfam11938
    Location:46 → 184
    DUF3456; TLR4 regulator and MIR-interacting MSAP
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QXT0.1 GenPept UniProtKB/Swiss-Prot:Q9QXT0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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