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Lgals1 galectin 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 56646, updated on 2-Nov-2024

Summary

Official Symbol
Lgals1provided by RGD
Official Full Name
galectin 1provided by RGD
Primary source
RGD:69355
See related
EnsemblRapid:ENSRNOG00000009884 AllianceGenome:RGD:69355
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables identical protein binding activity; lactose binding activity; and laminin binding activity. Involved in several processes, including cellular response to glucose stimulus; positive regulation of erythrocyte aggregation; and response to isolation stress. Located in cell surface. Biomarker of B-cell lymphoma; extrahepatic cholestasis; and lipoid nephrosis. Orthologous to human LGALS1 (galectin 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 2125.5), Heart (RPKM 1694.7) and 8 other tissues See more
Orthologs
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Genomic context

See Lgals1 in Genome Data Viewer
Location:
7q34
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (112365695..112368801)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (110485239..110488345)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (120153184..120156290)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene SH3-domain binding protein 1 Neighboring gene uncharacterized LOC134479755 Neighboring gene pyridoxal phosphatase Neighboring gene nucleolar protein 12 Neighboring gene TRIO and F-actin binding protein

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
enables carbohydrate binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables lactose binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables lactose binding IDA
Inferred from Direct Assay
more info
PubMed 
enables laminin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables laminin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables receptor ligand activity IEA
Inferred from Electronic Annotation
more info
 
enables receptor ligand activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in T cell costimulation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within T cell costimulation ISO
Inferred from Sequence Orthology
more info
 
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to glucose stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
NOT involved_in maintenance of protein location ISO
Inferred from Sequence Orthology
more info
 
involved_in myoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within myoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of T-helper 17 cell lineage commitment IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of T-helper 17 cell lineage commitment ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell-substrate adhesion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in plasma cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within plasma cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
PubMed 
NOT involved_in positive regulation of dendritic cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of erythrocyte aggregation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of viral entry into host cell IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of viral entry into host cell ISO
Inferred from Sequence Orthology
more info
 
involved_in response to axon injury IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to isolation stress IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
part_of galectin complex IEA
Inferred from Electronic Annotation
more info
 
part_of galectin complex ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
galectin-1
Names
14 kDa lectin
RL 14.5
S-Lac lectin 1
beta-galactoside-binding lectin L-14-I
gal-1
galaptin
lactose-binding lectin 1
lectin, galactose binding, soluble 1
lectin, galactoside-binding, soluble, 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019904.1NP_063969.1  galectin-1

    See identical proteins and their annotated locations for NP_063969.1

    Status: PROVISIONAL

    Source sequence(s)
    M19036
    UniProtKB/Swiss-Prot
    P11762
    UniProtKB/TrEMBL
    A0A8I6A5K0, A6HSN4
    Related
    ENSRNOP00000013538.5, ENSRNOT00000013538.8
    Conserved Domains (1) summary
    smart00276
    Location:11135
    GLECT; Galectin

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    112365695..112368801
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)