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TMPRSS4 transmembrane serine protease 4 [ Homo sapiens (human) ]

Gene ID: 56649, updated on 2-Nov-2024

Summary

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Official Symbol
TMPRSS4provided by HGNC
Official Full Name
transmembrane serine protease 4provided by HGNC
Primary source
HGNC:HGNC:11878
See related
Ensembl:ENSG00000137648 MIM:606565; AllianceGenome:HGNC:11878
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAP2; CAPH2; MT-SP2; TMPRSS3
Summary
This gene encodes a member of the serine protease family. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified as a gene overexpressed in pancreatic carcinoma. The encoded protein is membrane bound with a N-terminal anchor sequence and a glycosylated extracellular region containing the serine protease domain. The protein has been found to promote SARS-CoV-2 entry into host cells. [provided by RefSeq, Aug 2021]
Annotation information
Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in SARS-CoV-2 infection.
Expression
Biased expression in colon (RPKM 31.0), urinary bladder (RPKM 28.2) and 8 other tissues See more
Orthologs
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Genomic context

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See TMPRSS4 in Genome Data Viewer
Location:
11q23.3
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (118077078..118125505)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (118093464..118141906)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (117947793..117992605)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3941 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5580 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_19171 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117869597-117870098 Neighboring gene interleukin 10 receptor subunit alpha Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3942 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5581 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117881450-117881950 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_19207 Neighboring gene small integral membrane protein 35 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5582 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117935307-117935808 Neighboring gene RNA, 7SL, cytoplasmic 828, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117947648-117948243 Neighboring gene Sharpr-MPRA regulatory region 13014 Neighboring gene uncharacterized LOC105369517 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_19222 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:118000597-118001098 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:118001099-118001598 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:118014519-118015718 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5583 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3943 Neighboring gene sodium voltage-gated channel beta subunit 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:118024156-118024656 Neighboring gene sodium voltage-gated channel beta subunit 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. TMPRSS4 induces cancer stem cell-like properties in lung cancer cells and correlates with ALDH expression in NSCLC patients. de Aberasturi AL, et al. Cancer Lett, 2016 Jan 28. PMID 26546046
  2. Relationship between transmembrane serine protease expression and prognosis of esophageal squamous cell carcinoma. Liu GT, et al. J Biol Regul Homeost Agents, 2017 Oct-Dec. PMID 29254316
  3. A mutation in the serine protease TMPRSS4 in a novel pediatric neurodegenerative disorder. Lahiry P, et al. Orphanet J Rare Dis, 2013 Aug 17. PMID 23957953, Free PMC Article
  4. Overexpression of TMPRSS4 promotes tumor proliferation and aggressiveness in breast cancer. Li XM, et al. Int J Mol Med, 2017 Apr. PMID 28259959, Free PMC Article
  5. High TMPRSS4 expression is a predictor of poor prognosis in cervical squamous cell carcinoma. Cheng D, et al. Cancer Epidemiol, 2013 Dec. PMID 24012692

See all (65) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TMPRSS4 is a novel biomarker and correlated with immune infiltration in thyroid carcinoma.
    Title: TMPRSS4 is a novel biomarker and correlated with immune infiltration in thyroid carcinoma.
  2. Increased TRIM31 gene expression is positively correlated with SARS-CoV-2 associated genes TMPRSS2 and TMPRSS4 in gastrointestinal cancers.
    Title: Increased TRIM31 gene expression is positively correlated with SARS-CoV-2 associated genes TMPRSS2 and TMPRSS4 in gastrointestinal cancers.
  3. Utility of TMPRSS4 as a Prognostic Biomarker and Potential Therapeutic Target in Patients with Gastric Cancer.
    Title: Utility of TMPRSS4 as a Prognostic Biomarker and Potential Therapeutic Target in Patients with Gastric Cancer.
  4. Transmembrane Protease TMPRSS4 Promotes the Formation and Development of Mismatch Repair Deficient Colon Cancer Liver Metastasis.
    Title: Transmembrane Protease TMPRSS4 Promotes the Formation and Development of Mismatch Repair Deficient Colon Cancer Liver Metastasis.
  5. TMPRSS4 overexpression promotes the metastasis of colorectal cancer and predicts poor prognosis of stage III-IV colorectal cancer.
    Title: TMPRSS4 overexpression promotes the metastasis of colorectal cancer and predicts poor prognosis of stage III-IV colorectal cancer.
  6. COVID19 and SARSCoV2 host cell entry mediators: Expression profiling of TMRSS4 in health and disease.
    Title: COVID‑19 and SARS‑CoV‑2 host cell entry mediators: Expression profiling of TMRSS4 in health and disease.
  7. Role of miR-541-3p/TMPRSS4 in the metastasis and EMT of hepatocellular carcinoma.
    Title: Role of miR-541-3p/TMPRSS4 in the metastasis and EMT of hepatocellular carcinoma.
  8. Identification of a novel synthetic lethal vulnerability in non-small cell lung cancer by co-targeting TMPRSS4 and DDR1.
    Title: Identification of a novel synthetic lethal vulnerability in non-small cell lung cancer by co-targeting TMPRSS4 and DDR1.
  9. SARS-CoV-2 infects human mature enterocytes from the apical surface and triggers epithelial cell fusion. TMPRSS2 and TMPRSS4 serine proteases mediate this process by inducing cleavage of the S protein and enhancing membrane fusion.
    Title: TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes.
  10. Down-regulation of TMPRSS4 increases triple negative breast cancer cell radiosensitivity and the use of TMPRSS4 inhibitor can be encouraged for improving radiotherapy effectiveness in triple negative breast cancer radioresistant patients.
    Title: Downregulation of TMPRSS4 Enhances Triple-Negative Breast Cancer Cell Radiosensitivity Through Cell Cycle and Cell Apoptosis Process Impairment.
Submit: New GeneRIF Correction See all GeneRIFs (50)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables serine-type endopeptidase activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables serine-type peptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of growth rate IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of viral entry into host cell IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein processing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proteolysis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proteolysis NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within regulation of gene expression IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to wounding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in secretory granule IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
transmembrane protease serine 4
Names
channel-activating protease 2
channel-activating serine protease 2
membrane-type serine protease 2
transmembrane protease, serine 4
transmembrane serine protease 3
type II membrane serine protease

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011858.3 RefSeqGene

    Range
    5002..49814
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001083947.2 → NP_001077416.2  transmembrane protease serine 4 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in a shorter protein (isoform 3). The splice acceptor site used for the first intron of this variant is polymorphic in the human population (rs2276122), and it is not known if this variant can be expressed from individuals with the 'A' allele.
    Source sequence(s)
    AP000665, AP002800
    Consensus CDS
    CCDS44743.1
    UniProtKB/TrEMBL
    B7Z8X1
    Related
    ENSP00000430547.1, ENST00000522824.5
    Conserved Domains (3) summary
    smart00020
    Location:199 → 424
    Tryp_SPc; Trypsin-like serine protease
    cd00112
    Location:58 → 92
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cl02509
    Location:108 → 192
    SRCR_2; Scavenger receptor cysteine-rich domain

  2. NM_001173551.2 → NP_001167022.2  transmembrane protease serine 4 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The resulting isoform (4) lacks an internal 3-aa segment, compared to isoform 1.
    Source sequence(s)
    AP000665, AP002800
    Consensus CDS
    CCDS53716.1
    UniProtKB/TrEMBL
    B7Z8X1
    Related
    ENSP00000435184.1, ENST00000534111.5
    Conserved Domains (3) summary
    smart00020
    Location:202 → 427
    Tryp_SPc; Trypsin-like serine protease
    cd00112
    Location:56 → 90
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cl02509
    Location:106 → 195
    SRCR_2; Scavenger receptor cysteine-rich domain

  3. NM_001173552.2 → NP_001167023.2  transmembrane protease serine 4 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate in-frame splice site and lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The resulting isoform (5) lacks two internal segments, compared to isoform 1.
    Source sequence(s)
    AP000665, AP002800
    Consensus CDS
    CCDS53717.1
    UniProtKB/TrEMBL
    A0A087WTU6
    Related
    ENSP00000429209.1, ENST00000523251.5
    Conserved Domains (3) summary
    smart00020
    Location:164 → 389
    Tryp_SPc; Trypsin-like serine protease
    cd00112
    Location:18 → 52
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cl02509
    Location:68 → 157
    SRCR_2; Scavenger receptor cysteine-rich domain

  4. NM_001290094.2 → NP_001277023.2  transmembrane protease serine 4 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses an alternate splice junction at the end of a 5' exon compared to variant 1. The resulting isoform (6) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AP000665, AP002800
    UniProtKB/TrEMBL
    B7Z900
    Conserved Domains (3) summary
    smart00020
    Location:179 → 404
    Tryp_SPc; Trypsin-like serine protease
    cd00112
    Location:33 → 67
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cl02509
    Location:83 → 172
    SRCR_2; Scavenger receptor cysteine-rich domain

  5. NM_001290096.2 → NP_001277025.2  transmembrane protease serine 4 isoform 7

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) uses alternate splice junctions at the ends of three different exons compared to variant 1. The resulting isoform (7) is shorter at the N-terminus and lacks a short internal segment compared to isoform 1.
    Source sequence(s)
    AP000665, AP002800
    Consensus CDS
    CCDS76482.1
    UniProtKB/TrEMBL
    B7Z458, E7ESG9
    Related
    ENSP00000428814.1, ENST00000522307.5
    Conserved Domains (1) summary
    smart00020
    Location:57 → 282
    Tryp_SPc; Trypsin-like serine protease

  6. NM_019894.4 → NP_063947.2  transmembrane protease serine 4 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). The splice acceptor site used for the first intron of this variant is polymorphic in the human population (rs2276122), and it is not known if this variant can be expressed from individuals with the 'A' allele.
    Source sequence(s)
    AP000665, AP002800
    Consensus CDS
    CCDS31684.1
    UniProtKB/Swiss-Prot
    A8MU84, B0YJB0, B7Z8C5, E7ERX8, Q5XKQ6, Q6UX37, Q9NRS4, Q9NZA5
    UniProtKB/TrEMBL
    B7Z8X1
    Related
    ENSP00000416037.3, ENST00000437212.8
    Conserved Domains (3) summary
    smart00020
    Location:204 → 429
    Tryp_SPc; Trypsin-like serine protease
    cd00112
    Location:58 → 92
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam15494
    Location:108 → 197
    SRCR_2; Scavenger receptor cysteine-rich domain

RNA

  1. NR_110734.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction at the end of a 5' exon and lacks an alternate 3' exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AP000665, AP002800

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    118077078..118125505
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005271613.5 → XP_005271670.1  transmembrane protease serine 4 isoform X1

    UniProtKB/TrEMBL
    B7Z8X1
    Conserved Domains (4) summary
    smart00020
    Location:204 → 429
    Tryp_SPc; Trypsin-like serine protease
    cd00112
    Location:58 → 92
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:205 → 432
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    cl02509
    Location:108 → 197
    SRCR_2; Scavenger receptor cysteine-rich domain

  2. XM_011542901.3 → XP_011541203.1  transmembrane protease serine 4 isoform X3

    UniProtKB/TrEMBL
    B7Z8X1
    Conserved Domains (4) summary
    smart00020
    Location:199 → 424
    Tryp_SPc; Trypsin-like serine protease
    cd00112
    Location:58 → 92
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:200 → 427
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    cl02509
    Location:108 → 192
    SRCR_2; Scavenger receptor cysteine-rich domain

  3. XM_011542902.3 → XP_011541204.1  transmembrane protease serine 4 isoform X5

    UniProtKB/TrEMBL
    A0A087WTU6
    Conserved Domains (4) summary
    smart00020
    Location:166 → 391
    Tryp_SPc; Trypsin-like serine protease
    cd00112
    Location:20 → 54
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:167 → 394
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    cl02509
    Location:70 → 159
    SRCR_2; Scavenger receptor cysteine-rich domain

  4. XM_005271614.4 → XP_005271671.1  transmembrane protease serine 4 isoform X2

    See identical proteins and their annotated locations for XP_005271671.1

    UniProtKB/TrEMBL
    B7Z8X1
    Conserved Domains (4) summary
    smart00020
    Location:202 → 427
    Tryp_SPc; Trypsin-like serine protease
    cd00112
    Location:56 → 90
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:203 → 430
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    cl02509
    Location:106 → 195
    SRCR_2; Scavenger receptor cysteine-rich domain

  5. XM_047427259.1 → XP_047283215.1  transmembrane protease serine 4 isoform X4

  6. XM_005271615.4 → XP_005271672.1  transmembrane protease serine 4 isoform X6

    UniProtKB/TrEMBL
    A0A087WTU6
    Conserved Domains (4) summary
    smart00020
    Location:164 → 389
    Tryp_SPc; Trypsin-like serine protease
    cd00112
    Location:18 → 52
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:165 → 392
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    cl02509
    Location:68 → 157
    SRCR_2; Scavenger receptor cysteine-rich domain

  7. XM_047427260.1 → XP_047283216.1  transmembrane protease serine 4 isoform X7

  8. XM_011542903.4 → XP_011541205.1  transmembrane protease serine 4 isoform X8

    UniProtKB/TrEMBL
    A0AAQ5BHV3, A0AAQ5BHV4
    Related
    ENSP00000519645.1, ENST00000714378.1
    Conserved Domains (3) summary
    cd00112
    Location:58 → 92
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cl02509
    Location:108 → 197
    SRCR_2; Scavenger receptor cysteine-rich domain
    cl21584
    Location:205 → 304
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  9. XM_011542904.3 → XP_011541206.1  transmembrane protease serine 4 isoform X9

    Conserved Domains (2) summary
    cd00112
    Location:58 → 92
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cl02509
    Location:108 → 197
    SRCR_2; Scavenger receptor cysteine-rich domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    118093464..118141906
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054369356.1 → XP_054225331.1  transmembrane protease serine 4 isoform X1

  2. XM_054369358.1 → XP_054225333.1  transmembrane protease serine 4 isoform X3

  3. XM_054369360.1 → XP_054225335.1  transmembrane protease serine 4 isoform X5

  4. XM_054369357.1 → XP_054225332.1  transmembrane protease serine 4 isoform X2

  5. XM_054369359.1 → XP_054225334.1  transmembrane protease serine 4 isoform X4

  6. XM_054369361.1 → XP_054225336.1  transmembrane protease serine 4 isoform X6

  7. XM_054369362.1 → XP_054225337.1  transmembrane protease serine 4 isoform X7

  8. XM_054369363.1 → XP_054225338.1  transmembrane protease serine 4 isoform X8

  9. XM_054369364.1 → XP_054225339.1  transmembrane protease serine 4 isoform X9

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_183247.1: Suppressed sequence

    Description
    NM_183247.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NRS4.2 GenPept UniProtKB/Swiss-Prot:Q9NRS4

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