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NRIP3 nuclear receptor interacting protein 3 [ Homo sapiens (human) ]

Gene ID: 56675, updated on 28-Oct-2024

Summary

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Official Symbol
NRIP3provided by HGNC
Official Full Name
nuclear receptor interacting protein 3provided by HGNC
Primary source
HGNC:HGNC:1167
See related
Ensembl:ENSG00000175352 MIM:613125; AllianceGenome:HGNC:1167
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C11orf14; NY-SAR-105
Summary
Predicted to enable aspartic-type endopeptidase activity. Predicted to be involved in proteolysis. [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in testis (RPKM 15.1), brain (RPKM 14.4) and 4 other tissues See more
Orthologs
mouse all
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Genomic context

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See NRIP3 in Genome Data Viewer
Location:
11p15.4
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (8980576..9004505, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (9064768..9088208, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (9002123..9025548, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene achaete-scute family bHLH transcription factor 3 Neighboring gene TMEM9 domain family member B Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3117 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3118 Neighboring gene TMEM9B antisense RNA 1 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:9000257-9001066 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:9024725-9025644 Neighboring gene NRIP3 divergent transcript Neighboring gene signal peptide, CUB domain and EGF like domain containing 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3119 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:9068585-9069086 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3120 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4398 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4399 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:9087649-9088150 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:9088151-9088650 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4400 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:9116861-9117362 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:9117363-9117862 Neighboring gene microRNA 5691 Neighboring gene keratin 8 pseudogene 41

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. NRIP3: a novel translocation partner of MLL detected in a pediatric acute myeloid leukemia with complex chromosome 11 rearrangements. Balgobind BV, et al. Haematologica, 2009 Jul. PMID 19454493, Free PMC Article
  2. NRIP3 upregulation confers resistance to chemoradiotherapy in ESCC via RTF2 removal by accelerating ubiquitination and degradation of RTF2. Suo D, et al. Oncogenesis, 2020 Aug 24. PMID 32839439, Free PMC Article
  3. Immunomic analysis of human sarcoma. Lee SY, et al. Proc Natl Acad Sci U S A, 2003 Mar 4. PMID 12601173, Free PMC Article
  4. Comparative genomic sequencing reveals a strikingly similar architecture of a conserved syntenic region on human chromosome 11p15.3 (including gene ST5) and mouse chromosome 7. Amid C, et al. Cytogenet Cell Genet, 2001. PMID 11528127
  5. Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis. Wang X, et al. Cell, 2006 Nov 17. PMID 17110338

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NRIP3 is a novel translocation partner of MLL in acute myeloid leukemia
    Title: NRIP3: a novel translocation partner of MLL detected in a pediatric acute myeloid leukemia with complex chromosome 11 rearrangements.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables aspartic-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
nuclear receptor-interacting protein 3
Names
sarcoma antigen NY-SAR-105

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020645.3 → NP_065696.1  nuclear receptor-interacting protein 3

    See identical proteins and their annotated locations for NP_065696.1

    Status: VALIDATED

    Source sequence(s)
    AC026894, BC008835, DA249943
    Consensus CDS
    CCDS31422.1
    UniProtKB/Swiss-Prot
    Q86WD9, Q9NQ35
    UniProtKB/TrEMBL
    A0A8Q3WME3
    Related
    ENSP00000310205.3, ENST00000309166.8
    Conserved Domains (1) summary
    cd05480
    Location:110 → 212
    NRIP_C; NRIP_C; putative nuclear receptor interacting protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    8980576..9004505 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448608.2 → XP_024304376.1  nuclear receptor-interacting protein 3 isoform X1

    Conserved Domains (1) summary
    cd05480
    Location:42 → 144
    NRIP_C; putative nuclear receptor interacting protein

  2. XM_024448609.2 → XP_024304377.1  nuclear receptor-interacting protein 3 isoform X1

    Conserved Domains (1) summary
    cd05480
    Location:42 → 144
    NRIP_C; putative nuclear receptor interacting protein

  3. XM_047427262.1 → XP_047283218.1  nuclear receptor-interacting protein 3 isoform X2

    UniProtKB/TrEMBL
    B7Z3Y4
    Related
    ENSP00000432451.1, ENST00000531090.5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    9064768..9088208 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054369367.1 → XP_054225342.1  nuclear receptor-interacting protein 3 isoform X1

  2. XM_054369368.1 → XP_054225343.1  nuclear receptor-interacting protein 3 isoform X2

    UniProtKB/TrEMBL
    B7Z3Y4
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NQ35.1 GenPept UniProtKB/Swiss-Prot:Q9NQ35

Gene LinkOut

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