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Pigo phosphatidylinositol glycan anchor biosynthesis, class O [ Mus musculus (house mouse) ]

Gene ID: 56703, updated on 28-Oct-2024

Summary

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Official Symbol
Pigoprovided by MGI
Official Full Name
phosphatidylinositol glycan anchor biosynthesis, class Oprovided by MGI
Primary source
MGI:MGI:1861452
See related
Ensembl:ENSMUSG00000028454 AllianceGenome:MGI:1861452
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PIG-O
Summary
Predicted to enable mannose-ethanolamine phosphotransferase activity. Involved in GPI anchor biosynthetic process. Located in endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and skeleton. Human ortholog(s) of this gene implicated in hyperphosphatasia with impaired intellectual development syndrome 2. Orthologous to human PIGO (phosphatidylinositol glycan anchor biosynthesis class O). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in thymus adult (RPKM 11.6), duodenum adult (RPKM 11.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Pigo in Genome Data Viewer
Location:
4 A5; 4 22.98 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (43016964..43026369, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (43017626..43027696, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_10043 Neighboring gene STARR-positive B cell enhancer ABC_E46 Neighboring gene STARR-positive B cell enhancer ABC_E1029 Neighboring gene STARR-seq mESC enhancer starr_10044 Neighboring gene valosin containing protein Neighboring gene Fanconi anemia, complementation group G Neighboring gene STARR-positive B cell enhancer ABC_E6165 Neighboring gene STARR-positive B cell enhancer ABC_E1642 Neighboring gene STARR-positive B cell enhancer ABC_E9237 Neighboring gene stomatin (Epb7.2)-like 2 Neighboring gene atos homolog B Neighboring gene unc-13 homolog B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Requirement of PIG-F and PIG-O for transferring phosphoethanolamine to the third mannose in glycosylphosphatidylinositol. Hong Y, et al. J Biol Chem, 2000 Jul 7. PMID 10781593
  2. GPI7 is the second partner of PIG-F and involved in modification of glycosylphosphatidylinositol. Shishioh N, et al. J Biol Chem, 2005 Mar 11. PMID 15632136
  3. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
  4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • FLJ00350, mFLJ00350

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables mannose-ethanolamine phosphotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mannose-ethanolamine phosphotransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables mannose-ethanolamine phosphotransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphotransferase activity, for other substituted phosphate groups TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in GPI anchor biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in GPI anchor biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in GPI anchor biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
GPI ethanolamine phosphate transferase 3
Names
phosphatidylinositol-glycan biosynthesis class O protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305386.2 → NP_001292315.1  GPI ethanolamine phosphate transferase 3 isoform 2

    See identical proteins and their annotated locations for NP_001292315.1

    Status: VALIDATED

    Source sequence(s)
    AL672276
    UniProtKB/Swiss-Prot
    Q9CRY2, Q9JJI6
    UniProtKB/TrEMBL
    F6WGA5
    Conserved Domains (1) summary
    cd16023
    Location:64 → 344
    GPI_EPT_3; GPI ethanolamine phosphate transferase 3, PIG-O

  2. NM_001305387.2 → NP_001292316.1  GPI ethanolamine phosphate transferase 3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL672276
    Consensus CDS
    CCDS84720.1
    UniProtKB/Swiss-Prot
    Q9CRY2, Q9JJI6
    UniProtKB/TrEMBL
    A2AG36
    Related
    ENSMUSP00000069749.6, ENSMUST00000067481.6
    Conserved Domains (2) summary
    COG1524
    Location:42 → 433
    Npp1; Predicted pyrophosphatase or phosphodiesterase, AlkP superfamily [General function prediction only]
    cd16023
    Location:64 → 344
    GPI_EPT_3; GPI ethanolamine phosphate transferase 3, PIG-O

  3. NM_001423488.1 → NP_001410417.1  GPI ethanolamine phosphate transferase 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL672276
    UniProtKB/TrEMBL
    F6WGA5

  4. NM_020035.4 → NP_064419.3  GPI ethanolamine phosphate transferase 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL672276
    Consensus CDS
    CCDS18088.1
    UniProtKB/TrEMBL
    F6WGA5
    Related
    ENSMUSP00000095713.4, ENSMUST00000098109.10

RNA

  1. NR_186838.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL672276

  2. NR_186839.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL672276

  3. NR_186840.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL672276

  4. NR_186841.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL672276

  5. NR_186842.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL672276

  6. NR_186843.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL672276

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    43016964..43026369 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030253685.2 → XP_030109545.1  GPI ethanolamine phosphate transferase 3 isoform X2

    Conserved Domains (1) summary
    cl23718
    Location:1 → 65
    ALP_like; alkaline phosphatases and sulfatases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JJI6.2 GenPept UniProtKB/Swiss-Prot:Q9JJI6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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