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Dnajb12 DnaJ heat shock protein family (Hsp40) member B12 [ Mus musculus (house mouse) ]

Gene ID: 56709, updated on 2-Nov-2024

Summary

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Official Symbol
Dnajb12provided by MGI
Official Full Name
DnaJ heat shock protein family (Hsp40) member B12provided by MGI
Primary source
MGI:MGI:1931881
See related
Ensembl:ENSMUSG00000020109 AllianceGenome:MGI:1931881
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dj10; mDj10
Summary
Predicted to enable Hsp70 protein binding activity. Predicted to be involved in several processes, including ERAD pathway; cellular response to misfolded protein; and chaperone cofactor-dependent protein refolding. Predicted to be located in endoplasmic reticulum and nuclear membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and integumental system. Orthologous to human DNAJB12 (DnaJ heat shock protein family (Hsp40) member B12). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in kidney adult (RPKM 29.5), adrenal adult (RPKM 24.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Dnajb12 in Genome Data Viewer
Location:
10 B4; 10 29.64 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (59715405..59735118)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (59879583..59899296)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene mitochondrial calcium uptake 1 Neighboring gene predicted gene, 23803 Neighboring gene STARR-seq mESC enhancer starr_26780 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:59342224-59342333 Neighboring gene predicted gene 7413 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:59359601-59359774 Neighboring gene STARR-positive B cell enhancer ABC_E10610 Neighboring gene STARR-positive B cell enhancer ABC_E9340 Neighboring gene STARR-seq mESC enhancer starr_26783 Neighboring gene STARR-seq mESC enhancer starr_26784 Neighboring gene predicted gene, 46226 Neighboring gene STARR-seq mESC enhancer starr_26789 Neighboring gene predicted gene, 40673 Neighboring gene STARR-seq mESC enhancer starr_26790 Neighboring gene STARR-seq mESC enhancer starr_26791 Neighboring gene STARR-seq mESC enhancer starr_26792 Neighboring gene DNA-damage-inducible transcript 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature. Ohtsuka K, et al. Cell Stress Chaperones, 2000 Apr. PMID 11147971, Free PMC Article
  2. Phospho-proteomic analyses of B-Raf protein complexes reveal new regulatory principles. Eisenhardt AE, et al. Oncotarget, 2016 May 3. PMID 27034005, Free PMC Article
  3. Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program. Sundberg JP, et al. PLoS One, 2017. PMID 28700664, Free PMC Article
  4. The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase. Groh BS, et al. EMBO Rep, 2016 May. PMID 27113764, Free PMC Article
  5. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables Hsp70 protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables Hsp70 protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in ERAD pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in ERAD pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cellular response to misfolded protein IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to misfolded protein ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to misfolded protein ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in chaperone cofactor-dependent protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chaperone cofactor-dependent protein refolding ISO
Inferred from Sequence Orthology
more info
  
involved_in chaperone cofactor-dependent protein refolding ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in protein-containing complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dnaJ homolog subfamily B member 12
Names
DnaJ (Hsp40) homolog, subfamily B, member 12
DnaJ homolog 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001374756.1 → NP_001361685.1  dnaJ homolog subfamily B member 12 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC154040, AC155939
    Consensus CDS
    CCDS88010.1
    UniProtKB/TrEMBL
    Q8C4C9
    Related
    ENSMUSP00000116577.2, ENSMUST00000147914.8
    Conserved Domains (2) summary
    TIGR02349
    Location:111 → 237
    DnaJ_bact; chaperone protein DnaJ
    pfam09320
    Location:269 → 369
    DUF1977; Domain of unknown function (DUF1977)

  2. NM_001376970.1 → NP_001363899.1  dnaJ homolog subfamily B member 12 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC154040, AC155939
    UniProtKB/Swiss-Prot
    Q8K037, Q9QYI4
    Related
    ENSMUSP00000020309.7, ENSMUST00000020309.7

  3. NM_019965.3 → NP_064349.2  dnaJ homolog subfamily B member 12 isoform 2

    See identical proteins and their annotated locations for NP_064349.2

    Status: VALIDATED

    Source sequence(s)
    AC154040, AC155939
    Consensus CDS
    CCDS23867.1
    UniProtKB/Swiss-Prot
    Q8K037, Q9QYI4
    Related
    ENSMUSP00000122056.2, ENSMUST00000146590.8
    Conserved Domains (2) summary
    pfam00226
    Location:111 → 172
    DnaJ; DnaJ domain
    pfam09320
    Location:269 → 369
    DUF1977; Domain of unknown function (DUF1977)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    59715405..59735118
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QYI4.2 GenPept UniProtKB/Swiss-Prot:Q9QYI4

Gene LinkOut

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