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Litaf LPS-induced TN factor [ Mus musculus (house mouse) ]

Gene ID: 56722, updated on 12-May-2024

Summary

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Official Symbol
Litafprovided by MGI
Official Full Name
LPS-induced TN factorprovided by MGI
Primary source
MGI:MGI:1929512
See related
Ensembl:ENSMUSG00000022500 AllianceGenome:MGI:1929512
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TBX1; N4WBP3; 3222402J11Rik
Summary
Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; WW domain binding activity; and zinc ion binding activity. Acts upstream of or within cellular response to lipopolysaccharide; negative regulation of NIK/NF-kappaB signaling; and regulation of cytokine production. Predicted to be located in several cellular components, including cytoplasmic side of endosome membrane; cytoplasmic side of lysosomal membrane; and cytoplasmic side of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; retina nuclear layer; and vibrissa. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 1C. Orthologous to human LITAF (lipopolysaccharide induced TNF factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in colon adult (RPKM 67.6), genital fat pad adult (RPKM 52.8) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Litaf in Genome Data Viewer
Location:
16 A1; 16 6.28 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (10777137..10810985, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (10959273..10993121, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53936 Neighboring gene predicted gene, 21859 Neighboring gene STARR-positive B cell enhancer mm9_chr16:10979493-10979793 Neighboring gene STARR-positive B cell enhancer mm9_chr16:10993126-10993426 Neighboring gene predicted gene 4262 Neighboring gene predicted gene 10832 Neighboring gene MRT4, mRNA turnover 4 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. LITAF acts as a novel regulator for pathological cardiac hypertrophy. Xiang M, et al. J Mol Cell Cardiol, 2021 Jul. PMID 33823186
  2. LITAF (SIMPLE) regulates Wallerian degeneration after injury but is not essential for peripheral nerve development and maintenance: implications for Charcot-Marie-Tooth disease. Somandin C, et al. Glia, 2012 Oct. PMID 22729949
  3. LITAF mediation of increased TNF-α secretion from inflamed colonic lamina propria macrophages. Bushell KN, et al. PLoS One, 2011. PMID 21984950, Free PMC Article
  4. Molecular cloning and characterization of mouse LITAF cDNA: role in the regulation of tumor necrosis factor-alpha (TNF-alpha) gene expression. Bolcato-Bellemin AL, et al. J Endotoxin Res, 2004. PMID 15025820
  5. SIMPLE binds specifically to PI4P through SIMPLE-like domain and participates in protein trafficking in the trans-Golgi network and/or recycling endosomes. Moriwaki Y, et al. PLoS One, 2018. PMID 29953492, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LITAF Promotes Atherosclerotic Plaque Formation by Stimulating the NF-kappaB Inflammatory Pathway.
    Title: LITAF Promotes Atherosclerotic Plaque Formation by Stimulating the NF-κB Inflammatory Pathway.
  2. LITAF acts as a novel regulator for pathological cardiac hypertrophy.
    Title: LITAF acts as a novel regulator for pathological cardiac hypertrophy.
  3. SIMPLE Is an Endosomal Regulator That Protects Against NAFLD by Targeting the Lysosomal Degradation of EGFR.
    Title: SIMPLE Is an Endosomal Regulator That Protects Against NAFLD by Targeting the Lysosomal Degradation of EGFR.
  4. Sequential CRISPR-Based Screens Identify LITAF and CDIP1 as the Bacillus cereus Hemolysin BL Toxin Host Receptors.
    Title: Sequential CRISPR-Based Screens Identify LITAF and CDIP1 as the Bacillus cereus Hemolysin BL Toxin Host Receptors.
  5. results indicate that SIMPLE may regulate protein trafficking physiologically by localizing to the TGN and/or REs by binding PI4P.
    Title: SIMPLE binds specifically to PI4P through SIMPLE-like domain and participates in protein trafficking in the trans-Golgi network and/or recycling endosomes.
  6. Suggest LITAF as regulatory of pro-inflammatory and pro-fibrogenic pattern in non-alcoholic fatty liver disease.
    Title: LPS-induced TNF-α factor mediates pro-inflammatory and pro-fibrogenic pattern in non-alcoholic fatty liver disease.
  7. Data suggest that atypical inflammatory signaling kinetics may account for the gain of function elicited by the Litaf protein SIMPLE mutation in Charcot-Marie-Tooth Type 1C (CMT1C) patients.
    Title: Dysregulated Inflammatory Signaling upon Charcot-Marie-Tooth Type 1C Mutation of SIMPLE Protein.
  8. Mutation of SIMPLE (Litaf) in Charcot-Marie-Tooth 1C alters production of exosomes.
    Title: Mutation of SIMPLE in Charcot-Marie-Tooth 1C alters production of exosomes.
  9. This study demonistrated that loss of Litaf function is unlikely to be a major contributor to Charcot-Marie-Tooth disease, but modulating effects of macrophages need to be considered in the etiology of the disease.
    Title: LITAF (SIMPLE) regulates Wallerian degeneration after injury but is not essential for peripheral nerve development and maintenance: implications for Charcot-Marie-Tooth disease.
  10. Study provides evidence that LITAF contributes to the regulation of TNF-alpha in LPM harvested following acute inflammation.
    Title: LITAF mediation of increased TNF-α secretion from inflamed colonic lamina propria macrophages.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables WW domain binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of non-canonical NF-kappaB signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of macrophage cytokine production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic side of early endosome membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasmic side of late endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic side of late endosome membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasmic side of lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic side of lysosomal membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog
Names
LITAF-like protein
LPS-induced TNF-alpha factor homolog
Nedd4 WW domain-binding protein 3
estrogen-enhanced transcript protein
mEET

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019980.2 → NP_064364.1  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog

    See identical proteins and their annotated locations for NP_064364.1

    Status: VALIDATED

    Source sequence(s)
    AK076162, BX637242
    Consensus CDS
    CCDS27958.1
    UniProtKB/Swiss-Prot
    Q9EQI0, Q9JLJ0
    Related
    ENSMUSP00000023143.8, ENSMUST00000023143.14
    Conserved Domains (1) summary
    pfam10601
    Location:91 → 159
    zf-LITAF-like; LITAF-like zinc ribbon domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    10777137..10810985 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030249222.2 → XP_030105082.1  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog isoform X1

    UniProtKB/Swiss-Prot
    Q9EQI0, Q9JLJ0
    Related
    ENSMUSP00000112667.2, ENSMUST00000117360.8
    Conserved Domains (1) summary
    pfam10601
    Location:91 → 159
    zf-LITAF-like; LITAF-like zinc ribbon domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JLJ0.1 GenPept UniProtKB/Swiss-Prot:Q9JLJ0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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