Myl1 myosin, light chain 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Myl1provided by RGD
Official Full Name: myosin, light chain 1provided by RGD
Primary source: RGD:1598796
See related: EnsemblRapid:ENSRNOG00000013262 AllianceGenome:RGD:1598796
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: MLCf; Mcl3; Mlc1; Mlc3; MLC-f; MLC3-f
Summary: Predicted to be a structural constituent of muscle. Involved in cardiac muscle contraction. Located in contractile muscle fiber. Human ortholog(s) of this gene implicated in congenital myopathy 14. Orthologous to human MYL1 (myosin light chain 1). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Restricted expression toward (RPKM 42414.1) See more
Orthologs: human mouse all
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Genomic context

Location:: 9q32

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (75887224..75907696, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (68437514..68458256, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (73937820..73958480, complement)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

these results indicate that rAd-MLC3f injection rescues hindlimb unloading-induced decline in Vo in MHC type IIB single muscle fibers.
Title: Increasing myosin light chain 3f (MLC3f) protects against a decline in contractile velocity.
Metastasis of aggressive amoeboid sarcoma cells is dependent on Rho/ROCK/MLC signaling.
Title: Metastasis of aggressive amoeboid sarcoma cells is dependent on Rho/ROCK/MLC signaling.
Mass spectrometry analysis of ischemic rat cardiomyocyte MLC1 showed nitration of tyrosines 78 and 190
Title: Ischemia induced peroxynitrite dependent modifications of cardiomyocyte MLC1 increases its degradation by MMP-2 leading to contractile dysfunction.
Slowing of shortening velocity in tyep IIb fibers with hindlimb unloading involves a increase in the amount of MLC1-f.
Title: The roles of myosin ATPase activity and myosin light chain relative content in the slowing of type IIB fibers with hindlimb unweighting in rats.
RhoA and MLC phosphorylation are key mediators of VEGF-induced endothelial cell hyperpermeability
Title: HMG CoA reductase inhibition modulates VEGF-induced endothelial cell hyperpermeability by preventing RhoA activation and myosin regulatory light chain phosphorylation.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH129698 (e-PCR)
- UniSTS:212994

Mylf (e-PCR), detects polymorphism
- UniSTS:238141

BI277557 (e-PCR)
- UniSTS:243791

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables structural constituent of muscle	IEA Inferred from Electronic Annotation more info
enables structural constituent of muscle	ISO Inferred from Sequence Orthology more info
enables structural constituent of muscle	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cardiac muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in muscle contraction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in contractile muscle fiber	IBA Inferred from Biological aspect of Ancestor more info
located_in contractile muscle fiber	IDA Inferred from Direct Assay more info	PubMed
located_in myofibril	IEA Inferred from Electronic Annotation more info
located_in myofibril	ISO Inferred from Sequence Orthology more info
part_of myosin II complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: myosin light chain 1/3, skeletal muscle isoform

Names: MLC1/MLC3; MLC1F; MLC1F/MLC3F; MLC3F; alkali myosin light chain 1; alkali myosin light chain 3; fast myosin alkali light chain 1; fast myosin alkali light chain 3; myosin light chain A1/A2; myosin light chain alkali 1/2; myosin, light polypeptide 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001077656.1 → NP_001071124.1 myosin light chain 1/3, skeletal muscle isoform isoform 1f

See identical proteins and their annotated locations for NP_001071124.1

Status: VALIDATED

Source sequence(s)

BI277595, CB809837, CR755322

UniProtKB/Swiss-Prot

P02600, P02601

UniProtKB/TrEMBL

A6KFD8

Related

ENSRNOP00000017838.3, ENSRNOT00000017838.8

Conserved Domains (1) summary

PTZ00184
Location:40 → 188

PTZ00184; calmodulin; Provisional
NM_020104.2 → NP_064489.1 myosin light chain 1/3, skeletal muscle isoform isoform 3f

See identical proteins and their annotated locations for NP_064489.1

Status: VALIDATED

Source sequence(s)

BI277595, CR756356

UniProtKB/TrEMBL

A0A8I6A453, A6KFD9

Conserved Domains (1) summary

PTZ00184
Location:4 → 149

PTZ00184; calmodulin; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

75887224..75907696 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008767294.2 → XP_008765516.1 myosin light chain 1/3, skeletal muscle isoform isoform X1

Related

ENSRNOP00000086625.2, ENSRNOT00000112334.2

Conserved Domains (3) summary

PTZ00184
Location:72 → 211

PTZ00184; calmodulin; Provisional

cd00051
Location:149 → 210

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cl08302
Location:72 → 136

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...