Kcnip2 potassium voltage-gated channel interacting protein 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Kcnip2provided by RGD
Full Name: potassium voltage-gated channel interacting protein 2provided by RGD
Primary source: RGD:70887
See related: EnsemblRapid:ENSRNOG00000018018 AllianceGenome:RGD:70887
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Kchip2
Summary: Enables calcium ion binding activity and potassium channel regulator activity. Involved in clustering of voltage-gated potassium channels and regulation of potassium ion transmembrane transport. Located in dendrite and plasma membrane. Part of voltage-gated potassium channel complex. Orthologous to human KCNIP2 (potassium voltage-gated channel interacting protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 586.3), Brain (RPKM 49.4) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 1q54

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (254590172..254614437, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (244641147..244664939, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (265549610..265573393, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

acute stress in a rat model of cardiac arrest/resuscitation induced changes in native KChIP2 resembling those of KChIP2 depalmitoylation, promoting KChIP2 nuclear entry.
Title: Dynamic palmitoylation regulates trafficking of K channel interacting protein 2 (KChIP2) across multiple subcellular compartments in cardiac myocytes.
These findings establish MG53 as a novel regulator of KChIP2 and Ito,f by modulating NF-kappaB activity and reveal its critical role in electrophysiological remodeling in cardiac hypertrophy.
Title: MG53, A Novel Regulator of KChIP2 and I(to,f), Plays a Critical Role in Electrophysiological Remodeling in Cardiac Hypertrophy.
mRNA and KChIP2 promoter data suggest that the ISO-induced Ito,f reductions are, in part, mediated through reduced KChIP2 transcription caused by NF-kappaB activation.
Title: Reductions in the Cardiac Transient Outward K+ Current Ito Caused by Chronic β-Adrenergic Receptor Stimulation Are Partly Rescued by Inhibition of Nuclear Factor κB.
This study demonistrared that the expression and function of KCHIP2 channels in neurons of the rat bed nucleus of the stria terminalis.
Title: Distribution and functional expression of Kv4 family α subunits and associated KChIP β subunits in the bed nucleus of the stria terminalis.
Type 2 diabetes induces Endo-predominant prolongation of the action potential duration via a reduction of the fast component of Ito recovery from inactivation and reduced steady-state Ito, in which downregulation of Kv4.2 and KChIP2 may be involved.
Title: Type 2 diabetes induces subendocardium-predominant reduction in transient outward K+ current with downregulation of Kv4.2 and KChIP2.
KChIP2 can attenuate cardiac hypertrophy possibly through modulation of intracellular calcium concentration and calcineurin/NFAT pathway
Title: KChIP2 attenuates cardiac hypertrophy through regulation of Ito and intracellular calcium signaling.
STX1A inhibited partially the gating changes by KChIP2, suggesting a competitive interaction of these proteins for an overlapping binding region on the N-terminus of Kv4.2.
Title: Interaction of syntaxin 1A with the N-terminus of Kv4.2 modulates channel surface expression and gating.
Nuclear factor kappaB downregulates the transient outward potassium current I(to,f) through control of KChIP2 expression.
Title: Nuclear factor kappaB downregulates the transient outward potassium current I(to,f) through control of KChIP2 expression.
Silencing suppresses sodium channel messenger RNA (mRNA) levels, leaving potassium channel mRNAs unaltered.
Title: Post-transcriptional gene silencing of KChIP2 and Navbeta1 in neonatal rat cardiac myocytes reveals a functional association between Na and Ito currents.
Expressed in newborn rat heart ventricular myocytee.
Title: MAPK= mitogen-activated protein KChIP2? Unraveling signaling pathways controlling cardiac Ito expression.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI059157 (e-PCR)
- UniSTS:244513

RH128727 (e-PCR)
- UniSTS:212035

Kcnip2 (e-PCR), detects polymorphism
- UniSTS:547251

Kcnip2 (e-PCR), detects polymorphism
- UniSTS:478917

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
contributes_to A-type (transient outward) potassium channel activity	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables potassium channel regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables potassium channel regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables potassium channel regulator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables potassium channel regulator activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in action potential	ISO Inferred from Sequence Orthology more info
involved_in clustering of voltage-gated potassium channels	IDA Inferred from Direct Assay more info	PubMed
involved_in clustering of voltage-gated potassium channels	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in clustering of voltage-gated potassium channels	ISO Inferred from Sequence Orthology more info
involved_in membrane repolarization	ISO Inferred from Sequence Orthology more info
involved_in muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of potassium ion export across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in regulation of membrane repolarization	IEA Inferred from Electronic Annotation more info
involved_in regulation of membrane repolarization	ISO Inferred from Sequence Orthology more info
involved_in regulation of potassium ion export across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in regulation of potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of potassium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of potassium ion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of Kv4.2-KChIP2 channel complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	IDA Inferred from Direct Assay more info	PubMed
part_of voltage-gated potassium channel complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: A-type potassium channel modulatory protein KCNIP2; Kv channel-interacting protein 2

Names: A-type potassium channel modulatory protein 2; Kv channel-interacting protein 2-like; potassium channel auxiliary subunit KCHIP2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033961.1 → NP_001029133.1 A-type potassium channel modulatory protein KCNIP2 isoform c

See identical proteins and their annotated locations for NP_001029133.1

Status: VALIDATED

Description

Transcript Variant: This variant (c) lacks two exons in the 5' coding region compared to variant a. The resulting protein (isoform c) is shorter but has the same N- and C-termini compared to isoform a.

Source sequence(s)

BC085905, CK226309

UniProtKB/TrEMBL

A6JHJ8

Related

ENSRNOP00000024750.3, ENSRNOT00000024750.6

Conserved Domains (1) summary

COG5126
Location:43 → 209

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
NM_020094.2 → NP_064479.2 A-type potassium channel modulatory protein KCNIP2 isoform a

See identical proteins and their annotated locations for NP_064479.2

Status: VALIDATED

Description

Transcript Variant: This variant (a) represents the longest transcript and encodes the longest protein (isoform a).

Source sequence(s)

AF269283, BC085905, CK226309

UniProtKB/Swiss-Prot

Q9JI21, Q9JI22, Q9JI23, Q9JM59, Q9JM60

UniProtKB/TrEMBL

A6JHK0

Related

ENSRNOP00000024709.4, ENSRNOT00000024709.7

Conserved Domains (1) summary

COG5126
Location:93 → 259

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
NM_020095.2 → NP_064480.2 A-type potassium channel modulatory protein KCNIP2 isoform b

See identical proteins and their annotated locations for NP_064480.2

Status: VALIDATED

Description

Transcript Variant: This variant (b) lacks an exon in the 5' coding region compared to variant a. The resulting protein (isoform b) is shorter but has the same N- and C-termini compared to isoform a.

Source sequence(s)

AF269284, BC085905, CK226309

UniProtKB/TrEMBL

A6JHJ9

Related

ENSRNOP00000111656.1, ENSRNOT00000128712.1

Conserved Domains (1) summary

COG5126
Location:75 → 241

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

254590172..254614437 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063272081.1 → XP_063128151.1 Kv channel-interacting protein 2 isoform X4
XM_063272076.1 → XP_063128146.1 Kv channel-interacting protein 2 isoform X2
XM_063272069.1 → XP_063128139.1 Kv channel-interacting protein 2 isoform X1
XM_063272080.1 → XP_063128150.1 Kv channel-interacting protein 2 isoform X3
XM_008760450.4 → XP_008758672.1 Kv channel-interacting protein 2 isoform X5

See identical proteins and their annotated locations for XP_008758672.1

UniProtKB/TrEMBL

A0A8L2UQY6, D5LL09

Related

ENSRNOP00000050779.4, ENSRNOT00000048592.7

Conserved Domains (2) summary

COG5126
Location:53 → 219

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

cd00051
Location:140 → 211

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...