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Cym chymosin [ Rattus norvegicus (Norway rat) ]

Gene ID: 56825, updated on 17-Aug-2024

Summary

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Official Symbol
Cymprovided by RGD
Official Full Name
chymosinprovided by RGD
Primary source
RGD:708486
See related
EnsemblRapid:ENSRNOG00000018236 AllianceGenome:RGD:708486
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable aspartic-type endopeptidase activity. Predicted to be involved in proteolysis. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 4.2), Testes (RPKM 2.0) and 5 other tissues See more
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Genomic context

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Location:
2q34
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (197516947..197527307, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (194828739..194839096, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (209962848..209973205, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120100911 Neighboring gene potassium voltage-gated channel subfamily A member 10 Neighboring gene uncharacterized LOC102557194 Neighboring gene prokineticin 1 Neighboring gene uncharacterized LOC134485948

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Molecular cloning of neonate/infant-specific pepsinogens from rat stomach mucosa and their expressional change during development. Kageyama T, et al. Biochem Biophys Res Commun, 2000 Jan 27. PMID 10673373
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables aspartic-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
embryonic pepsinogen
Names
prochymosin
NP_064476.2
XP_038958924.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020091.2 → NP_064476.2  embryonic pepsinogen precursor

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A6HUT0, G3V8C5, Q9JJX1
    Related
    ENSRNOP00000024593.2, ENSRNOT00000024593.4
    Conserved Domains (2) summary
    pfam07966
    Location:19 → 47
    A1_Propeptide; A1 Propeptide
    cl11403
    Location:64 → 377
    pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    197516947..197527307 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039102996.2 → XP_038958924.1  embryonic pepsinogen isoform X1

    UniProtKB/TrEMBL
    Q9JJX1
    Related
    ENSRNOP00000105070.1, ENSRNOT00000127485.1
    Conserved Domains (2) summary
    pfam07966
    Location:7 → 35
    A1_Propeptide; A1 Propeptide
    cl11403
    Location:52 → 365
    pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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