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ZC3HAV1 zinc finger CCCH-type containing, antiviral 1 [ Homo sapiens (human) ]

Gene ID: 56829, updated on 7-Apr-2024

Summary

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Official Symbol
ZC3HAV1provided by HGNC
Official Full Name
zinc finger CCCH-type containing, antiviral 1provided by HGNC
Primary source
HGNC:HGNC:23721
See related
Ensembl:ENSG00000105939 MIM:607312; AllianceGenome:HGNC:23721
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZAP; ZC3H2; ARTD13; PARP13; FLB6421; ZC3HDC2
Summary
This gene encodes a CCCH-type zinc finger protein. This antiviral protein inhibits viral replication by recruiting cellular RNA degradation machineries to degrade viral mRNAs. The encoded protein plays an important role in the innate immune response against multiple DNA and RNA viruses, including Ebola virus, HIV and SARS-CoV-2 (which causes COVID-19). [provided by RefSeq, Sep 2021]
Annotation information
Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
Expression
Ubiquitous expression in bone marrow (RPKM 17.0), lymph node (RPKM 9.0) and 24 other tissues See more
Orthologs
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Genomic context

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Location:
7q34
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (139043515..139109720, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (140356423..140423001, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (138728261..138794466, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene zinc finger CCCH-type containing, antiviral 1 like Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:138720195-138721114 Neighboring gene uncharacterized LOC107986852 Neighboring gene microRNA 10399 Neighboring gene ribosomal protein L17 pseudogene 28 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr7:138786521-138787092 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26746 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:138794119-138794622 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26749 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26750 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26751 Neighboring gene Sharpr-MPRA regulatory region 4033 Neighboring gene Sharpr-MPRA regulatory region 8039 Neighboring gene intraflagellar transport 56 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:138859395-138860231 Neighboring gene NANOG hESC enhancer GRCh37_chr7:138867531-138868130 Neighboring gene Sharpr-MPRA regulatory region 12471 Neighboring gene MSL3 pseudogene 2 Neighboring gene FCF1 pseudogene 11

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Association of ZC3HAV1 single nucleotide polymorphisms with the susceptibility of Vogt-Koyanagi-Harada Disease. Wu Q, et al. BMC Med Genomics, 2023 May 23. PMID 37221558, Free PMC Article
  2. ZAP isoforms regulate unfolded protein response and epithelial- mesenchymal transition. Ly PT, et al. Proc Natl Acad Sci U S A, 2022 Aug 2. PMID 35881805, Free PMC Article
  3. The low abundance of CpG in the SARS-CoV-2 genome is not an evolutionarily signature of ZAP. Afrasiabi A, et al. Sci Rep, 2022 Feb 14. PMID 35165300, Free PMC Article
  4. Expression of Zinc-Finger Antiviral Protein in hCMEC/D3 Human Cerebral Microvascular Endothelial Cells: Effect of a Toll-Like Receptor 3 Agonist. Okudera M, et al. Neuroimmunomodulation, 2022. PMID 34937041
  5. Targeted Restriction of Viral Gene Expression and Replication by the ZAP Antiviral System. Ficarelli M, et al. Annu Rev Virol, 2021 Sep 29. PMID 34129371

See all (239) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Association of ZC3HAV1 single nucleotide polymorphisms with the susceptibility of Vogt-Koyanagi-Harada Disease.
    Title: Association of ZC3HAV1 single nucleotide polymorphisms with the susceptibility of Vogt-Koyanagi-Harada Disease.
  2. Expression of Zinc-Finger Antiviral Protein in hCMEC/D3 Human Cerebral Microvascular Endothelial Cells: Effect of a Toll-Like Receptor 3 Agonist.
    Title: Expression of Zinc-Finger Antiviral Protein in hCMEC/D3 Human Cerebral Microvascular Endothelial Cells: Effect of a Toll-Like Receptor 3 Agonist.
  3. ZAP isoforms regulate unfolded protein response and epithelial- mesenchymal transition.
    Title: ZAP isoforms regulate unfolded protein response and epithelial- mesenchymal transition.
  4. The low abundance of CpG in the SARS-CoV-2 genome is not an evolutionarily signature of ZAP.
    Title: The low abundance of CpG in the SARS-CoV-2 genome is not an evolutionarily signature of ZAP.
  5. Chemical genetics and proteome-wide site mapping reveal cysteine MARylation by PARP-7 on immune-relevant protein targets.
    Title: Chemical genetics and proteome-wide site mapping reveal cysteine MARylation by PARP-7 on immune-relevant protein targets.
  6. ZC3HAV1 promotes the proliferation and metastasis via regulating KRAS in pancreatic cancer.
    Title: ZC3HAV1 promotes the proliferation and metastasis via regulating KRAS in pancreatic cancer.
  7. The Zinc Finger Antiviral Protein ZAP Restricts Human Cytomegalovirus and Selectively Binds and Destabilizes Viral UL4/UL5 Transcripts.
    Title: The Zinc Finger Antiviral Protein ZAP Restricts Human Cytomegalovirus and Selectively Binds and Destabilizes Viral UL4/UL5 Transcripts.
  8. Association of Zinc Finger Antiviral Protein Binding to Viral Genomic RNA with Attenuation of Replication of Echovirus 7.
    Title: Association of Zinc Finger Antiviral Protein Binding to Viral Genomic RNA with Attenuation of Replication of Echovirus 7.
  9. The Interaction of Human and Epstein-Barr Virus miRNAs with Multiple Sclerosis Risk Loci.
    Title: The Interaction of Human and Epstein-Barr Virus miRNAs with Multiple Sclerosis Risk Loci.
  10. Coronavirus genomes carry the signatures of their habitats.
    Title: Coronavirus genomes carry the signatures of their habitats.
Submit: New GeneRIF Correction See all GeneRIFs (43)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of ZC3HAV1 PubMed

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Cellular biotinylated zinc finger CCCH-type, antiviral 1 (ZC3HAV1) protein is incorporated into HIV-1 Gag virus-like particles PubMed
gag Interaction of HIV-1 Gag with zinc finger CCCH-type, antiviral 1 (ZC3HAV1) is identified in a series of six affinity purification/mass spectrometry screens PubMed
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human zinc finger CCCH-type, antiviral 1 (ZC3HAV1) at amino acid residues 260-261 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ13288, MGC48898, DKFZp686F2052, DKFZp686H1869, DKFZp686O19171

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NOT enables NAD+ ADP-ribosyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
NOT enables NAD+ binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
NOT enables NAD+-protein ADP-ribosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding HDA PubMed 
enables cadherin binding HDA PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in defense response to virus IEA
Inferred from Electronic Annotation
more info
  
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of viral genome replication IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of mRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of mRNA catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of type I interferon production IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT involved_in protein poly-ADP-ribosylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to virus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to virus IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger CCCH-type antiviral protein 1
Names
ADP-ribosyltransferase diphtheria toxin-like 13
inactive Poly [ADP-ribose] polymerase 13
zinc finger CCCH domain-containing protein 2
zinc finger CCCH-type, antiviral 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029457.1 RefSeqGene

    Range
    5000..71205
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001363491.2 → NP_001350420.1  zinc finger CCCH-type antiviral protein 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC018644, AC083868, AI133088, BC040956, BU634030, BX571742, BX647974
    Consensus CDS
    CCDS94214.1
    UniProtKB/TrEMBL
    A8K9U6, C9J6P4
    Related
    ENSP00000418385.1, ENST00000464606.5
    Conserved Domains (2) summary
    smart00678
    Location:729 → 811
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd01439
    Location:906 → 1015
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...

  2. NM_020119.4 → NP_064504.2  zinc finger CCCH-type antiviral protein 1 isoform 1

    See identical proteins and their annotated locations for NP_064504.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant encodes isoform 1.
    Source sequence(s)
    AC018644, AC083868, BC040956, BX571742, BX647974
    Consensus CDS
    CCDS5851.1
    UniProtKB/Swiss-Prot
    A4D1R2, A4D1S4, Q7Z2W4, Q8IW57, Q8TAJ3, Q96N79, Q9H8R9, Q9P0Y7
    UniProtKB/TrEMBL
    A8K9U6
    Related
    ENSP00000242351.5, ENST00000242351.10
    Conserved Domains (3) summary
    smart00678
    Location:607 → 689
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd01439
    Location:784 → 893
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
    pfam00644
    Location:727 → 893
    PARP; Poly(ADP-ribose) polymerase catalytic domain

  3. NM_024625.4 → NP_078901.3  zinc finger CCCH-type antiviral protein 1 isoform 2

    See identical proteins and their annotated locations for NP_078901.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region and lacks several downstream exons, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC018644
    Consensus CDS
    CCDS55171.1
    UniProtKB/TrEMBL
    A0A514C937
    Related
    ENSP00000419855.1, ENST00000471652.1
    Conserved Domains (1) summary
    smart00678
    Location:607 → 689
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    139043515..139109720 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    140356423..140423001 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7Z2W4.3 GenPept UniProtKB/Swiss-Prot:Q7Z2W4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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