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Slc37a2 solute carrier family 37 (glycerol-3-phosphate transporter), member 2 [ Mus musculus (house mouse) ]

Gene ID: 56857, updated on 2-Nov-2024

Summary

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Official Symbol
Slc37a2provided by MGI
Official Full Name
solute carrier family 37 (glycerol-3-phosphate transporter), member 2provided by MGI
Primary source
MGI:MGI:1929693
See related
Ensembl:ENSMUSG00000032122 AllianceGenome:MGI:1929693
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ci2; G3PP; cI-2; Slc37a1
Summary
Predicted to enable glucose 6-phosphate:phosphate antiporter activity and glycerol-3-phosphate transmembrane transporter activity. Predicted to be involved in glucose-6-phosphate transport and phosphate ion transmembrane transport. Predicted to act upstream of or within glycerol-3-phosphate metabolic process; glycerol-3-phosphate transmembrane transport; and glycerophosphate shuttle. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human SLC37A2 (solute carrier family 37 member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in colon adult (RPKM 50.9), adrenal adult (RPKM 16.4) and 6 other tissues See more
Orthologs
human all
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Genomic context

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See Slc37a2 in Genome Data Viewer
Location:
9 A4; 9 20.74 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (37140445..37166709, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (37229149..37255738, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene Pbx/knotted 1 homeobox 2 Neighboring gene predicted gene, 48716 Neighboring gene STARR-positive B cell enhancer mm9_chr9:36984672-36984973 Neighboring gene STARR-positive B cell enhancer ABC_E249 Neighboring gene STARR-seq mESC enhancer starr_23796 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:37038155-37038413 Neighboring gene transmembrane protein 218 Neighboring gene protein transport protein Sec61 subunit gamma pseudogene Neighboring gene coiled-coil domain containing 15 Neighboring gene high mobility group box 3 pseudogene Neighboring gene predicted gene, 34885

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Sugar transporter Slc37a2 regulates bone metabolism in mice via a tubular lysosomal network in osteoclasts. Ng PY, et al. Nat Commun, 2023 Feb 21. PMID 36810735, Free PMC Article
  2. The major facilitator superfamily member Slc37a2 is a novel macrophage- specific gene selectively expressed in obese white adipose tissue. Kim JY, et al. Am J Physiol Endocrinol Metab, 2007 Jul. PMID 17356011
  3. Solute Carrier Family 37 Member 2 (SLC37A2) Negatively Regulates Murine Macrophage Inflammation by Controlling Glycolysis. Wang Z, et al. iScience, 2020 May 22. PMID 32428862, Free PMC Article
  4. Hematopoietic Cell-Specific SLC37A2 Deficiency Accelerates Atherosclerosis in LDL Receptor-Deficient Mice. Zhao Q, et al. Front Cardiovasc Med, 2021. PMID 34957260, Free PMC Article
  5. Cloning and characterization of a putative human glycerol 3-phosphate permease gene (SLC37A1 or G3PP) on 21q22.3: mutation analysis in two candidate phenotypes, DFNB10 and a glycerol kinase deficiency. Bartoloni L, et al. Genomics, 2000 Dec 1. PMID 11112347

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mast cell regranulation requires a metabolic switch involving mTORC1 and a glucose-6-phosphate transporter.
    Title: Mast cell regranulation requires a metabolic switch involving mTORC1 and a glucose-6-phosphate transporter.
  2. Using both living fish embryos and mammalian macrophages, we show that processing depends on the shrinkage and packaging of phagosomes into a unique cellular compartment, the gastrosome, with distinct molecular and ultra-structural characteristics. Loss of the transporter Slc37a2 blocks phagosomal shrinkage, resulting in the expansion of the gastrosome and the dramatic bloating of the cell.
    Title: Clearance by Microglia Depends on Packaging of Phagosomes into a Unique Cellular Compartment.
  3. The function of this macrophage-specific putative sugar transporter is central to the metabolism of the macrophage population specifically present in obese white adipose tissue.
    Title: The major facilitator superfamily member Slc37a2 is a novel macrophage- specific gene selectively expressed in obese white adipose tissue.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (2)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables glucose 6-phosphate:phosphate antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glucose 6-phosphate:phosphate antiporter activity ISO
Inferred from Sequence Orthology
more info
  
enables glucose 6-phosphate:phosphate antiporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables glycerol-3-phosphate transmembrane transporter activity ISA
Inferred from Sequence Alignment
more info
 PubMed 
Process Evidence Code Pubs
involved_in glucose-6-phosphate transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glucose-6-phosphate transport ISO
Inferred from Sequence Orthology
more info
  
involved_in glucose-6-phosphate transport ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within glycerol-3-phosphate metabolic process ISA
Inferred from Sequence Alignment
more info
 PubMed 
acts_upstream_of_or_within glycerol-3-phosphate transmembrane transport ISA
Inferred from Sequence Alignment
more info
 PubMed 
acts_upstream_of_or_within glycerophosphate shuttle ISA
Inferred from Sequence Alignment
more info
 PubMed 
involved_in phosphate ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphate ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphate ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
glucose-6-phosphate exchanger SLC37A2
Names
cAMP inducible 2 protein
cAMP inducible gene 2
cAMP-inducible protein 2
solute carrier family 37 (glycerol-3-phosphate transporter), member 1
solute carrier family 37 member 2
sugar phosphate exchanger 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145960.2 → NP_001139432.1  glucose-6-phosphate exchanger SLC37A2 isoform 1

    See identical proteins and their annotated locations for NP_001139432.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC138284, AC154434
    Consensus CDS
    CCDS52769.1
    UniProtKB/Swiss-Prot
    Q9WU81
    Related
    ENSMUSP00000124569.2, ENSMUST00000161114.2
    Conserved Domains (1) summary
    cl27298
    Location:25 → 478
    UhpC; Sugar phosphate permease [Carbohydrate transport and metabolism]

  2. NM_020258.5 → NP_064654.3  glucose-6-phosphate exchanger SLC37A2 isoform 2

    See identical proteins and their annotated locations for NP_064654.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 3' coding region which results in a frameshift, compared to variant 1. The encoded isoform (2) is shorter compared to isoform 1.
    Source sequence(s)
    AC138284, AC154434
    Consensus CDS
    CCDS40582.1
    UniProtKB/Swiss-Prot
    Q571N8, Q6P4P0, Q8BV90, Q8C144, Q8R1Y0, Q9WU81
    Related
    ENSMUSP00000110720.3, ENSMUST00000115068.10
    Conserved Domains (1) summary
    cl27298
    Location:25 → 478
    UhpC; Sugar phosphate permease [Carbohydrate transport and metabolism]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    37140445..37166709 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WU81.1 GenPept UniProtKB/Swiss-Prot:Q9WU81

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