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FSTL5 follistatin like 5 [ Homo sapiens (human) ]

Gene ID: 56884, updated on 2-Nov-2024

Summary

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Official Symbol
FSTL5provided by HGNC
Official Full Name
follistatin like 5provided by HGNC
Primary source
HGNC:HGNC:21386
See related
Ensembl:ENSG00000168843 MIM:620128; AllianceGenome:HGNC:21386
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable calcium ion binding activity. Predicted to be involved in cell differentiation and regulation of BMP signaling pathway. Predicted to be active in extracellular region. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in brain (RPKM 6.2), adrenal (RPKM 3.7) and 1 other tissue See more
Orthologs
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Genomic context

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See FSTL5 in Genome Data Viewer
Location:
4q32.2
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (161383897..162164000, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (164734139..165551147, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (162305049..163085152, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377514 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_75287 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_75306 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:162017778-162018000 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_75339 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_75379 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_75396 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:162118905-162119539 Neighboring gene uncharacterized LOC105377515 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_75444 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15779 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_75511 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:162314653-162315207 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:162446057-162446894 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22094 Neighboring gene Sharpr-MPRA regulatory region 7835 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:162743095-162743596 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:162748311-162748812 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:162748813-162749312 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr4:162857394-162858593 Neighboring gene uncharacterized LOC101928052 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_75539 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_75545 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_75588 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22095 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_75628 Neighboring gene methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase pseudogene 4 Neighboring gene uncharacterized LOC124900803 Neighboring gene uncharacterized LOC124900804

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Follistatin Like 5 (FSTL5) inhibits epithelial to mesenchymal transition in hepatocellular carcinoma. Zhang DY, et al. Chin Med J (Engl), 2020 Aug 5. PMID 32740091, Free PMC Article
  2. FSTL5 is a marker of poor prognosis in non-WNT/non-SHH medulloblastoma. Remke M, et al. J Clin Oncol, 2011 Oct 10. PMID 21911727
  3. Follistatin-like protein 5 inhibits hepatocellular carcinoma progression by inducing caspase-dependent apoptosis and regulating Bcl-2 family proteins. Li C, et al. J Cell Mol Med, 2018 Dec. PMID 30255547, Free PMC Article
  4. Down-regulated FSTL5 promotes cell proliferation and survival by affecting Wnt/β-catenin signaling in hepatocellular carcinoma. Zhang D, et al. Int J Clin Exp Pathol, 2015. PMID 26045876, Free PMC Article
  5. A novel colorectal cancer risk locus at 4q32.2 identified from an international genome-wide association study. Schmit SL, et al. Carcinogenesis, 2014 Nov. PMID 25023989, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Genetic association and characterization of FSTL5 in isolated clubfoot.
    Title: Genetic association and characterization of FSTL5 in isolated clubfoot.
  2. Follistatin Like 5 (FSTL5) inhibits epithelial to mesenchymal transition in hepatocellular carcinoma.
    Title: Follistatin Like 5 (FSTL5) inhibits epithelial to mesenchymal transition in hepatocellular carcinoma.
  3. Mechanistic investigation demonstrated that FSTL5 promoted Hepatocellular carcinoma (HCC) cell apoptosis in a caspase-dependent manner and regulated Bcl-2 family proteins. These results indicate that FSTL5 may be a potential novel target for HCC treatment, and a biomarker for tumor prognosis.
    Title: Follistatin-like protein 5 inhibits hepatocellular carcinoma progression by inducing caspase-dependent apoptosis and regulating Bcl-2 family proteins.
  4. FSTL5 plays a suppressive role in hepatocellular carcinoma. Down-regulation of FSTL5 could promote growth and survival of HCC cells by activation of Wnt/beta-catenin signaling.
    Title: Down-regulated FSTL5 promotes cell proliferation and survival by affecting Wnt/β-catenin signaling in hepatocellular carcinoma.
  5. FSTL5 expression denoted a dismal prognosis both within and across medulloblastoma subgroups.
    Title: FSTL5 is a marker of poor prognosis in non-WNT/non-SHH medulloblastoma.
  6. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A novel colorectal cancer risk locus at 4q32.2 identified from an international genome-wide association study.
EBI GWAS Catalog
Genome-wide association study of anthropometric traits and evidence of interactions with age and study year in Filipino women.
EBI GWAS Catalog

Variation

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See Variation Viewer (GRCh37.p13)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1263, DKFZp566D234

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of BMP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
follistatin-related protein 5
Names
follistatin-like protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001128427.3 → NP_001121899.1  follistatin-related protein 5 isoform b precursor

    See identical proteins and their annotated locations for NP_001121899.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    AA350666, AB033089, BI549596, DA243182
    Consensus CDS
    CCDS47158.1
    UniProtKB/Swiss-Prot
    Q8N475
    Related
    ENSP00000368462.4, ENST00000379164.8
    Conserved Domains (8) summary
    cd05736
    Location:357 → 432
    Ig2_Follistatin_like; Second immunoglobulin (Ig)-like domain of a follistatin-like molecule encoded by the Mahya gene and similar proteins
    smart00408
    Location:262 → 324
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:259 → 338
    IG_like; Immunoglobulin like
    COG3391
    Location:505 → 733
    YncE; DNA-binding beta-propeller fold protein YncE [General function prediction only]
    cd00104
    Location:92 → 132
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    pfam07679
    Location:340 → 429
    I-set; Immunoglobulin I-set domain
    pfam13499
    Location:181 → 241
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:179 → 242
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  2. NM_001128428.3 → NP_001121900.1  follistatin-related protein 5 isoform c precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site and lacks an exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (c) is shorter than isoform a.
    Source sequence(s)
    AA350666, AB033089, AK315152, BI549596, DA243182
    Consensus CDS
    CCDS47157.1
    UniProtKB/Swiss-Prot
    Q8N475
    Related
    ENSP00000389270.2, ENST00000427802.2
    Conserved Domains (8) summary
    cd05736
    Location:357 → 432
    Ig2_Follistatin_like; Second immunoglobulin (Ig)-like domain of a follistatin-like molecule encoded by the Mahya gene and similar proteins
    smart00408
    Location:262 → 324
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:259 → 338
    IG_like; Immunoglobulin like
    COG3391
    Location:496 → 724
    YncE; DNA-binding beta-propeller fold protein YncE [General function prediction only]
    cd00104
    Location:92 → 132
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    pfam07679
    Location:340 → 429
    I-set; Immunoglobulin I-set domain
    pfam13499
    Location:181 → 241
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:179 → 242
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  3. NM_020116.5 → NP_064501.2  follistatin-related protein 5 isoform a precursor

    See identical proteins and their annotated locations for NP_064501.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AA350666, AB033089, BC036502, BI549596, DA243182
    Consensus CDS
    CCDS3802.1
    UniProtKB/Swiss-Prot
    E9PCP6, Q8N475, Q9NSW7, Q9ULF7
    Related
    ENSP00000305334.4, ENST00000306100.10
    Conserved Domains (8) summary
    cd05736
    Location:358 → 433
    Ig2_Follistatin_like; Second immunoglobulin (Ig)-like domain of a follistatin-like molecule encoded by the Mahya gene and similar proteins
    smart00408
    Location:263 → 325
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:260 → 339
    IG_like; Immunoglobulin like
    COG3391
    Location:506 → 734
    YncE; DNA-binding beta-propeller fold protein YncE [General function prediction only]
    cd00104
    Location:93 → 133
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    pfam07679
    Location:341 → 430
    I-set; Immunoglobulin I-set domain
    pfam13499
    Location:182 → 242
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:180 → 243
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    161383897..162164000 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011532126.1 → XP_011530428.1  follistatin-related protein 5 isoform X1

    Conserved Domains (8) summary
    cd05736
    Location:358 → 433
    Ig2_Follistatin_like; Second immunoglobulin (Ig)-like domain of a follistatin-like molecule encoded by the Mahya gene and similar proteins
    smart00408
    Location:263 → 325
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:260 → 339
    IG_like; Immunoglobulin like
    COG3391
    Location:497 → 725
    YncE; DNA-binding beta-propeller fold protein YncE [General function prediction only]
    cd00104
    Location:93 → 133
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    pfam07679
    Location:341 → 430
    I-set; Immunoglobulin I-set domain
    pfam13499
    Location:182 → 242
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:180 → 243
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    164734139..165551147 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054350538.1 → XP_054206513.1  follistatin-related protein 5 isoform X2

    UniProtKB/Swiss-Prot
    E9PCP6, Q8N475, Q9NSW7, Q9ULF7

  2. XM_054350539.1 → XP_054206514.1  follistatin-related protein 5 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N475.2 GenPept UniProtKB/Swiss-Prot:Q8N475

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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